Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials

Abstract

BackgroundSeveral studies reported that curcumin supplementation could improve non-alcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the efficacy of curcumin/turmeric supplementation on liver enzymes in patients with NAFLD.MethodsPubMed, Scopus, Web of Science and Google Scholar were systematically searched until December 2017. We included randomized controlled trials (RCTs) which examined effect of curcumin/turmeric supplementation on NAFLD in adult participants. Main outcome was alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Potential risks of bias (ROB) were assessed by using Cochrane ROB tool.ResultsAll included studies showed low ROB in most of item of Cochrane ROB tool. Meta-analysis of 4 randomized controlled trials including 228 subjects showed a trend toward significant reduction of ALT blood concentrations in subgroup with ≥1000 mg/day curcumin supplementation (–11.36 IU/L, 95% CI: –22.75 to 0.02; I2:51%). Meta-analysis showed a significant reduction of AST in studies with 8-weeks administration (–9.22 IU/L, 95% CI: –12.77 to –5.67; I2: 49%).ConclusionThis review suggests that curcumin/turmeric might have a favorable effect on NAFLD in higher dosage. Further high-quality studies with large-scale and higher dosage are warranted.

Effect of sour tea supplementation on liver enzymes, lipid profile, blood pressure, and antioxidant status in patients with non‐alcoholic fatty liver disease: A double‐blind randomized controlled clinical trial

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The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

“…Stringent lifestyle changes are often only accepted by limited numbers of patients, while at the same time, despite the significant effects of oral antidiabetic drugs, excessive use of these synthetic compounds like thiazolidinediones (TZDs) can lead to various adverse effects including higher risk of bone fractures, congestive heart failure, and gastrointestinal problems (Grunberger, ; A. Hadi, Mohammadi, Hadi, Roshanravan, & Kafeshani, ; Kerrison et al, ; Nissen & Wolski, ; Yang et al, ). As a result, to combat this pandemic, other effective adjunctive therapies, which are synergistic with lifestyle and pharmacological interventions, are necessary (A. Hadi, Pourmasoumi, Mohammadi, Javaheri, & Rouhani, ; Mansour‐Ghanaei, Pourmasoumi, Hadi, & Joukar, ). Nowadays, complementary and alternative medicine is widely applied alongside the methods mentioned (Pourmasoumi et al, ; Vishnu, Mini, & Thankappan, ).…”

Does turmeric/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta‐analysis of randomized controlled trials

“…Non‐alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease worldwide (Fazel, Koenig, Sayiner, Goodman, & Younossi, ), and the prevalence of NAFLD that is associated with metabolic syndrome is progressively increasing (Kopec & Burns, ; Mansour‐Ghanaei, Pourmasoumi, Hadi, & Joukar, ). NAFLD is defined as the presence of lipid deposition in hepatocytes in individuals who drink little or no alcohol (Angulo, ; Kopec & Burns, ).…”