Efficacy of different sentinel lymph node biopsy protocols in oral squamous cell carcinoma: Systematic review and meta‐analysis

Ajuria, M. Suárez; Torreira, Mercedes Gallas; García‐García, Abel; Marichalar-Mendía, Xabier; Chamorro-Petronacci, Cintia; Padín-Iruegas, María Elena; Pérez‐Sayáns, Mario

doi:10.1002/hed.27042

Cited by 7 publications

(2 citation statements)

References 44 publications

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“…Более того, БСЛУ показала высокие чувствительность (от 71,4 до 95 %) и специфичность по результатам двух последних проспективных исследований и нескольких диагностических метаанализов [22][23][24][25][26][27]. В связи с этим данный метод был включен в рекомендации по лечению рака СОПР стадии сТ1-2 Национальной всеобщей онкологической сети США (National Comprehensive Cancer Networ, NCCN).…”

Section: Discussionunclassified

“…пришли к выводу, что статистически значимых различий в показателях общей выживаемости и выживаемости без / до прогрессирования между БСЛУ и радикальной шейной лимфа денэктомией при плоскоклеточном раке СОПР стадии cT1-2N0 нет. Это позволяет предположить, что БСЛУ может быть альтернативой ра дикальной шейной лимфаденэктомии при данном заболевании ранних стадий и отсутствии метастатического поражения регионарных ЛУ [27].…”

Section: Discussionunclassified

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Sentinel lymph node biopsy experience in squamous cell carcinoma of the oral mucosa сT1–2N0M0

Sevryukov,

Polkin,

Panaseikin

et al. 2024

Opuholi golovy i šei

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Introduction. Head and neck cancer is the 7th most common malignancy worldwide; squamous cell carcinoma of the oral mucosa are almost a third of tumors of that localization. metastatic lesions of the neck lymph nodes are an unfavorable prognostic factor for malignant tumors of that location since it is associated with a 50 % decrease in overall survival. In this regard, the detection of metastases to the neck lymph nodes is an important component of high-quality oncological care for patients with that pathology. Aim. To evaluate the efficiency of sentinel lymph node biopsy in squamous cell carcinoma of cavity of mouth mucosa cT1–2N0м0. Materials and methods. 72 patients were included in trial at the age from 21 to 74 (mean 57.3) with confirmed squamous cell carcinoma of cavity of mouth mucosa cT1–2N0м0. No evidence of regional metastasis, by preoperative examination, including ultrasound, computed tomography with intravenous contrast was observed. All patients received radioisotope research to determine localization of sentinel lymph nodes, and then biopsy of that nodes was performed. Before obtaining information about the status of the sentinel lymph node, radical neck dissection was not performed. Pathology report with immunohistochemical investigation was performed by pathologist of A. f. Tsyb medical Radiological Research Center – branch of the National medical Research Radiological Center, ministry of Health of Russia. Results. When assessing efficiency of sentinel lymph node method, true positives results (detection of metastasis in sentinel lymph node) were achieved in 3 (4.17 %) out of 72 cases. follow up time was from 1 to 69 months. Among those cases, where metastasis in sentinel lymph nodes were not detected, relapse in regional lymph nodes was developed in 3 (4.35 %) out of 69 cases. Radical neck dissection was performed in cases with metastasis in sentinel lymph nodes. The specificity of method was 95 %, the predictive value of a negative result was 0.04. Conclusion. Sentinel lymph neck node biopsy is an effective method of subclinical locoregional metastases detection in cancer of oral mucosa cT1–2N0m0. In our study of sentinel lymph neck node biopsy, oncological outcomes were comparable to radical neck dissection, with fewer postoperative complications.

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Section: Discussionunclassified

Sentinel lymph node biopsy experience in squamous cell carcinoma of the oral mucosa сT1–2N0M0

Sevryukov,

Polkin,

Panaseikin

et al. 2024

Opuholi golovy i šei

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Efficacy of different sentinel lymph node biopsy protocols in oral squamous cell carcinoma: Systematic review and meta‐analysis

et al. 2022

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The sentinel node biopsy (SNB) is highly protocolized in other cancers, however, this is not the case for oral squamous cell carcinoma patients, hence our objective was to evaluate the different protocols published. A specific study protocol was designed and subsequently registered on PROSPERO (Ref. CRD42021279217). Twenty-three articles were included in the meta-analysis. The grouped sensitivity of the SNB was 82% (95% CI: 0.74-0.88), and the grouped specificity was 100% (95% CI: 0.99-1.00). The use of other radiotracers other than pre-operative lopamidol showed higher values of sensitivity of 82.80% (95% CI: 76.90%-87.50%; p < 0.001). The use of the blue dye stain showed higher sensitivity values of 85.60% (95% CI: 71.90%-93.20%), compared to sensitivity values of 77.50% when it was not used (95% CI: 69.10%-84.20%) (p < 0.001). Diagnostic rates are variable and they were significantly better when 99mTc was used in all its variations and accompanied by the blue dye staining.

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Measures of performance for sentinel lymph node biopsy in oro-oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis

Garau

Gregorio

Nonne

et al. 2023

Clin Transl Imaging

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Efficacy of different sentinel lymph node biopsy protocols in oral squamous cell carcinoma: Systematic review and meta‐analysis

Cited by 7 publications

References 44 publications

Sentinel lymph node biopsy experience in squamous cell carcinoma of the oral mucosa сT1–2N0M0

Sentinel lymph node biopsy experience in squamous cell carcinoma of the oral mucosa сT1–2N0M0

Efficacy of different sentinel lymph node biopsy protocols in oral squamous cell carcinoma: Systematic review and meta‐analysis

Measures of performance for sentinel lymph node biopsy in oro-oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis

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