Efficacy of DNA vaccines carrying Eimeria acervulina lactate dehydrogenase antigen gene against coccidiosis

Song, Hongyan; Ren, Yan; Xu, Lixin; Song, Xiaoling; Shah, Muhammad Ali; Zhu, Huili; Li, Xiangrui

doi:10.1016/j.exppara.2010.05.015

Cited by 70 publications

(49 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concentrations of the IgG levels are expressed as mean ± S.D. oocyst decrease ratio and ACIs than chickens immunized with pVAX1-LDH [31]. In the present study, we also observed that the concentrations of IFN-γ and IL-2 in the vaccinated chickens were at least 2.5 folds of that of the control groups.…”

Section: Discussionsupporting

confidence: 50%

Eimeria maxima microneme protein 2 delivered as DNA vaccine and recombinant protein induces immunity against experimental homogenous challenge

Huang

Zhang

et al. 2015

Parasitology International

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 50%

Eimeria maxima microneme protein 2 delivered as DNA vaccine and recombinant protein induces immunity against experimental homogenous challenge

Huang

Zhang

et al. 2015

Parasitology International

Self Cite

View full text Add to dashboard Cite

“…These advances in molecular biology provide a strong platform for the design and production of DNA vaccines. 14 described and reviewed the protective immunity induced by DNA against a large variety of viruses, 15 bacteria 16 17 and protozoa [18][19][20][21][22][23][24][25] in murine models or chickens. DNA immunization has also been investigated for the treatment of cancer 26 and auto-immune diseases.…”

Section: Why Dna Vaccine?mentioning

confidence: 99%

Nanoparticles for DNA Vaccine Delivery

Shah¹,

He²,

Li³

et al. 2014

j biomed nanotechnol

View full text Add to dashboard Cite

Nanotechnology is the development of engineered devices or materials at the micro molecular level in the nanometer range. The properties of nanoparticles that these could be designed, manufactured and introduced into the human body, have led to its application in various fields of medicine. They are being used for construction of diagnostic devices, contrast agents, analytical tools, physical therapy, drug discovery and drug delivery vehicles. The DNA vaccines have been emerged as best remedy for problematic diseases being capable of producing humoral and cellular immune responses as well as the safest vaccines so far. There are a large number of infectious diseases against which traditional vaccines failed to respond effectively. Especially, viral diseases and cancer where DNA vaccines seem to be the better option. However, the magnitude of immune responses produced by them in primates is not sufficient to be used in human beings. There is an evidence that these immune responses can be augmented by using properly structured nano-sized particles that may avoid DNA degradation and facilitate targeted and controlled delivery to antigen presenting cells. Adsorption, formulation or encapsulation with particles has been found to stabilize DNA formulations. The use of nanoparticles for vaccine delivery is a platform technology and has been applied for delivery of a variety of existing and potential vaccines successfully.

show abstract

“…acervulina is one of the most prevalent Eimeria species in chicken. Until now, few genes of this coccidian have been reported and tested for their immunogenicity [24,25]. The search for new antigens and testing their protective ability against challenge with E. acervulina will facilitate the development of a new generation of vaccines against this parasite.…”

Section: Introductionmentioning

confidence: 99%

Identification and molecular characterization of a novel antigen of Eimeria acervulina

Zhu

Ren

Wang

et al. 2012

Molecular and Biochemical Parasitology

Self Cite

View full text Add to dashboard Cite

Efficacy of DNA vaccines carrying Eimeria acervulina lactate dehydrogenase antigen gene against coccidiosis

Cited by 70 publications

References 36 publications

Eimeria maxima microneme protein 2 delivered as DNA vaccine and recombinant protein induces immunity against experimental homogenous challenge

Eimeria maxima microneme protein 2 delivered as DNA vaccine and recombinant protein induces immunity against experimental homogenous challenge

Nanoparticles for DNA Vaccine Delivery

Identification and molecular characterization of a novel antigen of Eimeria acervulina

Contact Info

Product

Resources

About