Efficacy of doramectin against field nematode infections of cattle in Latin America

Eddi, C.; Bianchin, I.; Honer, Michael Robin; Muniz, R.A.; Caracostantogolo, Jorge; Nascimento, Y. A. do

doi:10.1016/0304-4017(93)90221-8

Cited by 23 publications

(2 citation statements)

References 5 publications

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“…Doramectin had been shown to be effective in the control of a broad range of parasitic nematode infections in cattle. 17,18 Doramectin has a minimum persistent activity of 14 days, 19 and was 100% effective against eyeworms (Thelazia spp) in calves. 20 Thelazia and Spirocerca both are genera of the nematode family Thelaziidae Railliet, and it seemed plausible that doramec-tin could be effective in the treatment of spirocercosis.…”

Section: Discussionmentioning

confidence: 99%

Spirocerca lupi Esophageal Granulomas in 7 Dogs: Resolution after Treatment with Doramectin

Berry

2000

J Vet Int Med

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Seven dogs with Spirocerca lupi esophageal granulomas were identified based on the site of involvement (ie, distal esophagus) and characteristic endoscopic appearance. Six dogs presented with signs of esophageal disease and 1 dog was asymptomatic. Ova were only identified in the feces of 2 dogs. On thoracic radiographs, 4 dogs had evidence of a caudodorsal mediastinal mass, and 2 of these dogs had spondylitis of midthoracic vertebrae. On endoscopy, single esophageal nodules were observed in 5 dogs, 1 dog had 3 nodules, and 1 dog had 6 nodules. All 7 dogs were treated with doramectin at a dosage of 200 microg/kg SC at 14-day intervals for 3 treatments. Dogs had physical and endoscopic examinations at 2, 4, and 6 weeks after treatment. By 6 weeks, clinical signs had resolved in 6 dogs (1 dog was asymptomatic), and the esophageal nodules had completely resolved in 4 dogs, and incompletely resolved in 3 dogs. Two dogs with incomplete resolution were treated again with doramectin at 500 microg/kg PO daily for an additional 6 weeks. Complete resolution of the esophageal nodules was confirmed by endoscopy in all dogs. Nodules had resolved in 4 dogs by 6 weeks, in 2 dogs by 12 weeks (after 6 weeks additional daily oral therapy), and in 1 dog 22 months after the initial 200 microg/kg treatment regimen. No dog experienced adverse effects to the drug, and all symptomatic dogs have been free of disease for periods ranging from 3 to 4 years.

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Section: Discussionmentioning

confidence: 99%

Spirocerca lupi Esophageal Granulomas in 7 Dogs: Resolution after Treatment with Doramectin

Berry

2000

J Vet Int Med

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“…1 The avermectins are widely used as an anthelmintic for cattle in Brazil and around the world because of its high efficacy against a broad spectrum of nematode parasites and certain ectoparasites. Several studies have reported the efficacy of ivermectin 2,3,4,5 , doramectin 6,7,8,9,10 and abamectin 11,12,13,14 against the most important cattle gastrointestinal nematodes, the efficacy against adult Cooperia punctata of 95% is demonstrated.…”

Section: Identification Of Ivermectin and Doramectin-resistant Coopermentioning

confidence: 99%

Identificação de Cooperia punctata (Linstow, 1907) resistente a ivermectina e doramectina em um rebanho leiteiro no Estado do Rio de Janeiro, Brasil

Cardoso

Martins

Sant'Anna

et al. 2008

Braz. J. Vet. Res. Anim. Sci.

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Resistência antihelmíntica é um problema potencial para o controle de nematodas em bovinos e pode causar perdas econômicas na indústria de bovinos leiteiros e de cortes. O objetivo deste estudo foi determinar a eficácia da ivermectina, doramectna e abamectina em bezerros infectados naturalmente e experimentalmente para Cooperia punctata em um rebanho bovino leiteiro. Testes de redução da contagem de ovos fecais foram conduzidos em bezerros infectados naturalmente que foram tratados com soluções injetáveis de ivermectina, doramectina e abamectina. Amostras fecais foram colhidas no dia do tratamento, dia 0, e nos dias 7 e 14 após o tratamento e cultura de larvas foram feitas nas amostras positivas. Um teste controlado foi realizado usando 18 bezerros infectados artificialmente,alocados em três grupos com seis animais cada: Grupo I - controle, sem tratamento; Grupo II - ivermectina, solução injetável, 200µg/kg; Grupo III - doramectina, solução injetável, 200µg/kg. Amostras fecais foram colhidas no dia do tratamento, dia 0, e nos dias 3, 7, 9 e 14 após o tratamento. Nos dias 14, 15 e 16, dois animais de cada grupo foram eutanaziados e cargas de parasitos pulmonares e gastrintestinais foram determinados. Os resultados dos testes de redução da contagem de ovos fecais em bezerros infectados naturalmente mostraram redução no dia 14 após o tratamento de - 4,45 a 11,49% para ivermectina; 32.31 a 60.40% para doramectina e 85,05% para abamectina. O único parasito identificado na cultura de larvas foi Cooperia spp. O Teste Controlado mostrou uma redução da contagem de ovos fecais no dia 14 após o tratamento de 51.47% e 96.08% para ivermectina e doramectina, respectivamente. Redução da contagem de adultos neste teste controlado foi de 53.91% e 82.43% para ivermectina e doramectina, respectivamente. Somente C. punctata foi recuperado nas necropsias. Assim, esta cepa de C. punctata foi considerado resistente ao tratamento com ivermectina e doramectina e sugere uma possível resistência para abamectina pelo teste de redução da contagem de ovos fecais.

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Therapeutic and persistent efficacy of doramectin against Dermatobia hominis in cattle

Moya-Borja

Muniz

Sanavria

et al. 1993

Veterinary Parasitology

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Efficacy of doramectin against field nematode infections of cattle in Latin America

Cited by 23 publications

References 5 publications

Spirocerca lupi Esophageal Granulomas in 7 Dogs: Resolution after Treatment with Doramectin

Spirocerca lupi Esophageal Granulomas in 7 Dogs: Resolution after Treatment with Doramectin

Identificação de Cooperia punctata (Linstow, 1907) resistente a ivermectina e doramectina em um rebanho leiteiro no Estado do Rio de Janeiro, Brasil

Therapeutic and persistent efficacy of doramectin against Dermatobia hominis in cattle

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