Efficacy of early intravenous bolus oxycodone or fentanyl in emergence from general anaesthesia and postoperative analgesia following laparoscopic cholecystectomy: A randomized trial

Choi, Young-Hee; Park, Sang-Wook; Kwon, Hyun-Jung; Choi, Jae-Moon; Lee, Yu‐Mi

doi:10.1177/0300060515594194

Cited by 14 publications

(26 citation statements)

References 30 publications

(50 reference statements)

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“…Four studies [7,8,11,13] reported this outcome. Choi 2015 [7] and Koch 2008[11] used the following methods to assess sedation: "S, asleep, easily aroused; 1, awake and alert; 2, occasionally drowsy, easily aroused; 3, frequently drowsy, falls asleep during conversation; 4, somnolent, minimal or no response to stimulation". Meta-analysis showed that no difference between oxycodone and fentanyl for sedation score at 2 (2RCTs, N = 127, RR 2.06, 95% CI 0.56 to 7.60, Figure 4).…”

Section: Sedationmentioning

confidence: 80%

“…However, only four of them [8,10,12,13] contributed data for meta-analysis. Result showed that oxycodone can significantly reduce the pain intensity than other opioids (fentanyl, alfentanil or morphine) in 30 minutes (2 RCTs [7] found that the pain intensity in oxycodone is significantly lower than fentanyl group in half hours post operation, but this effect did not last longer than 0.5 hours. Koch 2008[11] stated that the intensity of deep abdominal pain was significantly lower in the oxycodone group at arrival, after 30, 60 and 90 min and at discharge from the PACU.…”

Section: Meta-analysis Pain Intensitymentioning

confidence: 99%

“…Nine studies [7][8][9][10][11][12][13][14][15] measured pain intensity by VAS or NRS scale. However, only four of them [8,10,12,13] contributed data for meta-analysis.…”

Section: Meta-analysis Pain Intensitymentioning

confidence: 99%

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Oxycodone versus other opioids analgesia after laparoscopic surgery: a meta-analysis

Yang

et al. 2019

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Background: Intravenous opioids are administered for management of visceral pain after laparoscopic surgery. Whether oxycodone has an advantage over other opioids in the treatment of visceral pain is not yet clear. Methods: This article evaluates the analgesic efficiency and adverse events of oxycodone and other opioids including alfentany, sufentanyl, fentanyl and morphine for the treatment of post laparoscopic surgery visceral pain. This review was conducted according to the methodological standards described in the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. The PubMed, Embase and Cochrane libraries were searched in December 2018. Results: Ten studies were included in this review. The sample size was 815 participants. The results showed that compared with morphine and fentanyl, oxycodone had a more potent analgesic efficacy at the first day after laparoscopic surgery, especially during the first 0.5h. There was no significant difference in sedation between the two groups. Compared to morphine and fentanyl, oxycodone was more likely to increase the risk of dizziness and drowsiness. The overall patients satisfaction had no significant difference between oxycodone versus other opioids. Conclusions: Oxycodone is a superior analgesic within 24h after laparoscopic surgery with careful regards to its adverse effects.

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Section: Sedationmentioning

confidence: 80%

Section: Meta-analysis Pain Intensitymentioning

confidence: 99%

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Oxycodone versus other opioids analgesia after laparoscopic surgery: a meta-analysis

Yang

et al. 2019

Preprint

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“…Previous studies supported that oxycodone may offer advantages over fentanyl for pain control [9,10]. Recent data demonstrated that a lower dose of oxycodone was sufficient to control acute post-operative pain [22,23].…”

Section: Discussionmentioning

confidence: 99%

“…In recent decades, intravenous oxycodone has been used for perioperative pain management [7]. Comparing to morphine or fentanyl, intravenous oxycodone provides better pain relief, especially for visceral pain [8][9][10]. During induction of general anesthesia, previous studies have shown that the attenuation effect of oxycodone on hemodynamic responses is comparable to fentanyl, and the complication rates are also similar between these two opioids [10,11].…”

mentioning

confidence: 99%

Safety and efficacy of intravenous oxycodone in geriatric patients undergoing general anesthesia for ophthalmic surgeries:a randomized controlled trial

Yao

et al. 2019

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Background: The present study aimed to compare the safety and efficacy of intravenous oxycodone with fentanyl in geriatric patients undergoing general anesthesia for ophthalmic surgeries. Methods: 107 geriatric patients (age 65-79 years old) with the ASA physical status 1 or 2 undergoing general anesthesia for glaucoma or retina surgeries between May 2016 and November 2017 were divided into three groups: Group O1, Group O2, and Group F. After exclusion, 105 patients were included for the final analysis, with 35 patients in each group. Oxycodone (0.1 mg/kg in Group O1, or 0.2 mg/kg in Group O2) or fentanyl (2 mcg/kg in Group F) was administered intravenously during induction of general anesthesia. Patient demographics, surgical time and anesthesia time, perioperative hemodynamic parameters and requirement of vasoactive medication, postoperative pain and requirement of rescue analgesics, postoperative sedation level and recovery time, and perioperative complications were recorded. Results: Patients in Group O1 experienced less clinically significant hypotension compared to either Group F or Group O2. Consistently, patients in Group O1 required less intraoperative vasoactive medication (ephedrine) than those in Group F. The postoperative pain on extubation was more severe and more patients required rescue analgesia in Group F compared to Group O2, but not Group O1. The recovery time was longer and sedation level was higher in Group O2 than Group F or O1. The incidence of hypoxia during postoperative recovery was higher in Group O2 than Group F or O1. Conclusion: Oxycodone at 0.1mg/kg can be a safe and effective application for geriatric patients undergoing general anesthesia for ophthalmic surgeries, with adequate pain control and less side effects. Trial registration: The study was registered at http://www.chictr.org.cn , Clinical Trial Number: ChiCTR-IPR-16007927. Date of registration: February 15, 2016. Keywords: Oxycodone, Fentanyl, Geriatric, Ophthalmology, General anesthesia

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Effectiveness of premedication protocol using intravenous fentanyl to reduce pain associated with femoral artery closure device placement

et al. 2019

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Efficacy of early intravenous bolus oxycodone or fentanyl in emergence from general anaesthesia and postoperative analgesia following laparoscopic cholecystectomy: A randomized trial

Abstract: Oxycodone relieves immediate postoperative pain significantly better than fentanyl, and is not associated with an increase in side-effects in patients undergoing laparoscopic cholecystectomy.

Cited by 14 publications

References 30 publications

Oxycodone versus other opioids analgesia after laparoscopic surgery: a meta-analysis

Oxycodone versus other opioids analgesia after laparoscopic surgery: a meta-analysis

Safety and efficacy of intravenous oxycodone in geriatric patients undergoing general anesthesia for ophthalmic surgeries:a randomized controlled trial

Effectiveness of premedication protocol using intravenous fentanyl to reduce pain associated with femoral artery closure device placement

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