Efficacy of Ficus tikoua Bur. extract in ethylene glycol-induced urolithiasis model in SD rats

Abstract

The development of new herbal preparations for the treatment of urolithiasis is an urgent task of medical science. Ficus have attracted the attention of pharmacologists due to a wide range of biological properties, including antioxidant, anti-inflammatory, antibacterial and antifungal activity. We studied the effectiveness of Ficus tikoua Bur. in SD rats in which urolithiasis was induced by 6 weeks of oral administration of ethylene glycol 0.5% ad libitum instead of drinking water. Administration of the extract of Ficus tikoua Bur., as well as comparative drug Cystone® after modeling of urolithiasis lead to the restoration of diuresis and the concentration of inorganic phosphates starting from the 6th week of the experiment. The use of the Ficus tikoua Bur. extract for 6 weeks, both during the modeling of urolithiasis and during the recovery period, led to the restoration of the percentage of lymphocytes in the blood, content of sodium, chlorine and inorganic phosphates in the blood to the control level. Thus, the extract of Ficus tikoua Bur. seems to be a promising drug for effective treatment of the initial stages of the development of urolithiasis.

Appearance quality, nutritional value, and aroma components of wild diguo (Ficus tikoua Bur.) fruit collected from southwest China

“…As a traditional Chinese medicine, the entire plant has been used to treat various ailments, including cough, sore throat, chronic bronchitis, dyspepsia, dysentery, diarrhea, jaundice, edema, mastadenitis, rheumatism, impetigo, etc. (Bervinova et al., 2022 ; Yao et al., 2022 ). It is also cultivated for ornamental, groundcover, and bio‐ecological restoration purposes due to its adaptability, strong asexual reproductive capacity, and potential ability to absorb heavy metals (Chen et al., 2023 ).…”