Efficacy of fipronil, amitraz and (S)-methoprene combination spot-on for dogs against adult dog fleas (Ctenocephalides canis, Curtis, 1826)

Bouhsira, Émilie; Yoon, Stephen; Roques, Martine; Manavella, Coralie; Vermot, Solange; Cramer, Luiz G.; Ollagnier, C; Franc, Michel

doi:10.1016/j.vetpar.2011.03.048

Cited by 12 publications

(10 citation statements)

References 17 publications

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“…These results are similar to those obtained with fipronil where 99.6% and 100% efficacies were observed for 37 days after treatment (Cadiergues et al, 2001;Bouhsira et al, 2011). Spinosad administered orally following US labeling (at doses ranging from 31.65 to 54.85 mg/kg) has been shown to provide good efficacy against C. canis for 3 weeks only at 24 h counts (Franc and Bouhsira, 2009).…”

Section: Discussionsupporting

confidence: 83%

“…Although the cat flea Ctenocephalides felis is considered the predominant flea species found on both dogs and cats worldwide (Rust and Dryden, 1997), the prevalence on dogs of another species, Ctenocephalides canis, appears greater than previously believed (Bouhsira et al, 2011). C. canis has been reported as the main flea species infesting dogs in several countries, including Ireland and Greece (Baker and Hatch, 1972;Koutinas et al, 1995;Xhaxhiu et al, 2009;Farkas et al, 2009;Chee et al, 2008;Guzman, 1984;Gonzales et al, 2004;Alcaino et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Curative and preventive efficacy of orally administered afoxolaner against Ctenocephalides canis infestation in dogs

Dumont¹,

Gale²,

Chester³

et al. 2014

Veterinary Parasitology

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The efficacy of orally administered afoxolaner against adult dog fleas, Ctenocephalides canis, was evaluated in a controlled, blinded study. A total of 32 dogs were infested with 100 adult unfed fleas approximately 24h prior to treatment and then at weekly intervals for 5 weeks after treatment. Live fleas were counted upon removal at 12h (for 16 dogs) and 24h (for the remaining 16 dogs) after treatment (for counts performed the first week) or after infestation (for counts performed on subsequent weeks). In addition, flea eggs were collected from each pen and counted for the dogs with flea removal at 24h. Dosing of individual dogs was achieved using a combination of the chewable tablets to be as close as possible to the minimum effective dose of 2.5mg/kg. The percent efficacy of the afoxolaner treatment was ≥ 99.0% for all 24-h flea counts. For flea counts performed 12h after treatment or infestations, the percent efficacy was ≥ 94.1% up to Day 21. After Day 1, no flea eggs were recovered from the afoxolaner treated group, providing 100% reduction in numbers of flea eggs recovered versus untreated control group. This study confirmed that a single oral treatment with afoxolaner provided excellent efficacy against infestations by C. canis within 12-24h after treatment, prevented re-infestations, and completely prevented egg production from new flea infestations for up to 5 weeks.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Curative and preventive efficacy of orally administered afoxolaner against Ctenocephalides canis infestation in dogs

Dumont¹,

Gale²,

Chester³

et al. 2014

Veterinary Parasitology

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“…Although the cat flea Ctenocephalides felis is considered to be the predominant flea species found on both cats and dogs worldwide [ 1 - 3 ], the prevalence of Ctenocephalides canis appears to be greater than previously believed in many regions [ 1 , 4 ]. C. canis is the predominant flea species of dogs in eastern and central European countries [ 5 - 10 ].…”

Section: Introductionmentioning

confidence: 99%

Sustained speed of kill and repellency of a novel combination of fipronil and permethrin against Ctenocephalides canis flea infestations in dogs

et al. 2015

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BackgroundCtenocephalides canis is a major flea species in dogs in several European countries. The new topical combination of fipronil and permethrin (Frontline Tri-Act®/Frontect®, Merial) has been developed to control fleas, ticks, mosquitoes, sandflies and biting flies on dogs. Considering the repellent and insecticidal effects of permethrin and the insecticidal effect of fipronil, the efficacy of the combination against fleas including C. canis was expected to be rapid. The study was conducted to measure the 1-hour, 6-hour and 24-hour efficacy, as well as the repellent activity, of the fipronil-permethrin combination on treated versus untreated dogs.Methods12 Beagle dogs were randomly allocated to one of two groups based on pre-treatment live flea counts. Dogs in Group 1 remained untreated whereas dogs in Group 2 were treated once on Day 0. Each dog was infested with 100 unfed adult C. canis on Days 2, 7, 14, 21 and 28. Dogs were combed for fleas 1 and 6 h after each infestation. Following this examination, fleas remaining on the liner at the bottom of each cage were collected and counted. All live fleas were placed back on each dog after the 1- and 6-hour counts. A comb-count was performed at 24 h post infestation on all dogs.ResultsTreated dogs had significantly (p ≤ 0.01) lower flea counts than untreated dogs at every time point. The percent efficacy was ≥99.1% at 6 and 24 h after each weekly challenge up to the month. The 1-hour counts also showed good efficacy of 96.5%, 98.9%, 92.0%, 70.2% and 55.7% on Days 2, 7, 14, 21 and 28, respectively. The repellent efficacy, assessed on the liners at 1 h, was 86.5%, 94.9%, 79.5%, 58.4% and 43.9% on Days 2, 7, 14, 21 and 28, respectively.ConclusionsThis study demonstrates the beneficial effect of the fipronil and permethrin combination against C. canis, providing both a repellent and insecticidal effect as early as 1 h post infestation, and >99.1% efficacy calculated at 6 h during a month.

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“…Products containing fipronil are almost the only option for tick treatment of cats and dogs as the other common acaricides, permethrin and amitraz, are indicated for dogs only [4,5] and are contraindicated for use in cats due to serious safety concerns. Flumethrin, the acaricidal active component in Kiltix ® collars (propoxur 10%/flumethrin 2.25%), is a highly potent acaricide known to be safe in various animal species including cattle, sheep and dogs but also cats: the Kiltix ® collar was, up to-date the only broadly marketed pyrethroid containing formulation suitable for cats.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe

Stanneck

Rass²,

Radeloff³

et al. 2012

Parasites Vectors

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BackgroundThe objective of these two GCP multicentre European clinical field studies was to evaluate the long-term efficacy and safety of a new imidacloprid/flumethrin collar (Seresto®, Bayer AnimalHealth, Investigational Veterinary Product(IVP)) in dogs and cats naturally infested with fleas and/or ticks in comparison to a dimpylat collar ("Ungezieferband fuer Hunde/fuer Katzen", Beaphar, Control Product (CP)).Methods232 (IVP) and 81 (CP) cats and 271(IVP) and 129 (CP) dogs were treated with either product according to label claims and formed the safety population. Flea and tick counts were conducted in monthly intervals for up to 8 months in the efficacy subpopulation consisting of 118 (IVP) + 47 (CP) cats and 197 (IVP) + 94 (CP) dogs. Efficacy was calculated as reduction of infestation rate within the same treatment group and statistically compared between the two treatment groups.ResultsPreventive efficacy against fleas in cats/dogs varied in the IVP group between 97.4%/94.1% and 100%/100% (overall mean: 98.3%/96.7%) throughout the 8 month period and in the CP group between 57.1%/28.2% and 96.1%/67.8% (overall mean: 79.3%/57.9%). Preventive efficacy against ticks in cats/dogs varied in the IVP group between 94.0%/91.2% and 100%/100% (overall mean: 98.4%/94.7%) throughout the 8 month period and in the CP group between 90.7%/79.9% and 100%/88.0% (overall mean: 96.9%/85.6%). The IVP group was statistically non-inferior to the CP group, and on various assessment days, statistical superiority was proven for flea and tick count reduction in dogs and cats. Both treatments proved to be safe in dogs and cats with mainly minor local observations at the application site. There was moreover, no incidence of any mechanical problem with the collar in dogs and cats during the entire study period.ConclusionsThe imidacloprid/flumethrin collar proved to reduce tick counts by at least 90% and flea counts by at least 95% for a period of at least 7-8 months in cats and dogs under field conditions. Therefore, it can be used as sustainable long-term preventative, covering the whole flea and tick season.

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Efficacy of fipronil, amitraz and (S)-methoprene combination spot-on for dogs against adult dog fleas (Ctenocephalides canis, Curtis, 1826)

Cited by 12 publications

References 17 publications

Curative and preventive efficacy of orally administered afoxolaner against Ctenocephalides canis infestation in dogs

Curative and preventive efficacy of orally administered afoxolaner against Ctenocephalides canis infestation in dogs

Sustained speed of kill and repellency of a novel combination of fipronil and permethrin against Ctenocephalides canis flea infestations in dogs

Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe

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