Efficacy of Flavonoids in Increasing Insulin Sensitivity among Pregnant Women with Gestational Diabetes Mellitus: A Systematic Review

Lacorte, Laarni Hannah; Yanga, Jirah Faith; Samson, Kian Steven; Aclibon, Yvan Keith; Buenaventura, Jea Nhycka; Reyes, John Francis Rey Delos; Demabasa, Sarah Lois; Fernando, Ariel Efraim; Laguerta, Cyrelle Jade

doi:10.5530/ajbls.2022.11.38

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the placenta, nobiletin-added combination therapy also suppressed placental AKT and activated MAPK ERK1/2 during GDM. It also inhibited expression of CXCL8 secretion in placental tissue and VAT ( Lacorte et al, 2022 ). These findings suggest that nobiletin works by activating the NF-kB, AKT, and MAPK/ERK1/2 pathways to enhance insulin sensitivity in tissues that have been impaired by inflammation and proinflammatory chemokines.…”

Section: Therapeutic Strategies To Target CXC Chemokines In Pe and Gdmmentioning

confidence: 99%

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Ullah,

Zhao,

Singla

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births. Preeclampsia (PE), which increases maternal and fetal morbidity and mortality, affects approximately 3%–5% of pregnancies worldwide. Nevertheless, it is unclear what triggers PE and GDM to develop. Therefore, the development of novel moderator therapy approaches is a crucial advancement. Chemokines regulate physiological defenses and maternal-fetal interaction during healthy and disturbed pregnancies. Chemokines regulate immunity, stem cell trafficking, anti-angiogenesis, and cell attraction. CXC chemokines are usually inflammatory and contribute to numerous reproductive disorders. Fractalkine (CX3CL1) may be membrane-bound or soluble. CX3CL1 aids cell survival during homeostasis and inflammation. Evidence reveals that CXC and CX3CL1 chemokines and their receptors have been the focus of therapeutic discoveries for clinical intervention due to their considerable participation in numerous biological processes. This review aims to give an overview of the functions of CXC and CX3CL1 chemokines and their receptors in the pathophysiology of PE and GDM. Finally, we examined stimulus specificity for CXC and CX3CL1 chemokine expression and synthesis in PE and GDM and preclinical and clinical trials of CXC-based PE and GDM therapies.

show abstract

Section: Therapeutic Strategies To Target CXC Chemokines In Pe and Gdmmentioning

confidence: 99%

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Ullah,

Zhao,

Singla

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…In addition, flavonoids can significantly increase insulin sensitivity in pregnant women which is associated with the NF-, Akt, and MAPK Erk1/2 pathways. 42 Polyphenols are the main contributors to antioxidants that allow phenols to donate electrons or hydrogen atoms to neutralize free radicals. Phenol also reduces the rate of oxidation by preventing the formation of ROS and deactivating ROS.…”

Section: In Vitro and In Vivo Studies On The Antioxidant Activity Of ...mentioning

confidence: 99%

A Systematic Review on the Hypoglycemic Potentials of Mahogany (Swietenia spp.) Seeds as Antioxidants in the Management of Gestational Diabetes Mellitus

2024

TJNPR

View full text Add to dashboard Cite

The prevalence of Gestational Diabetes Mellitus (GDM) has increased worldwide alongside an increase in the prevalence of type 2 diabetes mellitus (T2DM). Indonesia is endowed with a rich biodiversity and medicinal plants, including mahogany. Mahogany seeds contain flavonoids, saponins, and limonoids. Limonoid compounds have been shown to inhibit the production of reactive oxygen species (ROS) through the activation of antioxidant enzymes. This study focuses on a systematic review of the potential of the seeds of Swietenia spp. as an antioxidant in GDM. A systematic literature review of 13 scientific articles comprising 12 original research articles and 1 review article published within the last 7-8 years from various scientific databases was conducted. The original research articles were categorized into in vivo and in vitro studies with respect to the antioxidant activity of Swietenia spp. seeds. The systematic review provided a comprehensive understanding of the potential of mahogany seeds as an antioxidant and its role in the management of GDM.

show abstract

Efficacy of Flavonoids in Increasing Insulin Sensitivity among Pregnant Women with Gestational Diabetes Mellitus: A Systematic Review

Cited by 2 publications

References 0 publications

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

A Systematic Review on the Hypoglycemic Potentials of Mahogany (Swietenia spp.) Seeds as Antioxidants in the Management of Gestational Diabetes Mellitus

Contact Info

Product

Resources

About