Efficacy of florfenicol for treatment of naturally occurring infectious bovine keratoconjunctivitis

Abstract

Florfenicol administered SC (1 dose) or IM (2 doses 48 hours apart) was effective for treatment of calves with naturally occurring IBK.

Infectious Bovine Keratoconjunctivitis (Pinkeye)

“…49 In the experimental study, calves were randomly assigned to receive 2 doses of florfenicol (20 mg/kg IM at 0 and 48 hours), 1 dose of florfenicol (40 mg/kg SC one time), or no treatment (control group). Ulcer healing rates were significantly greater in calves of the IM and SC groups (6.2 and 4.8 times, respectively) versus the control group.…”

“…In a study of florfenicol against naturally occurring IBK, corneal ulcer healing rates were significantly greater in the IM and SC groups (3.3 and 2.6 times, respectively) versus the control group and both routes of administration were considered equally effective. 49 …”

Protective effect of florfenicol on acute lung injury induced by lipopolysaccharide in mice

“…It shows strong activity against both Gram-positive and Gram-negative bacteria. It has been widely used to treat a broad array of infectious diseases, such as bovine and porcine respiratory tract infections [7][8][9], actinobacillus pleuropneumonia in pigs [10], and infectious bovine keratoconjunctivitis [11,12]. It has been shown to be effective and safe.…”

Effects of florfenicol on early cytokine responses and survival in murine endotoxemia

“…It showed strong activity against both Gram-positive and Gram-negative bacteria. It has been widely used to treat a broad array of infectious diseases, such as for the treatments of bovine and porcine respiratory tract infections [6][7][8], actinobacillus pleuropneumonia in pigs [9] and infectious bovine keratoconjunctivitis [10,11], and it showed to be effective and safe. However, whether florfenicol has anti-inflammatory effect in addition to exerting its antibacterial activity and is effective in the treatment and management of some inflammatory diseases have not been demonstrated.…”