2013
DOI: 10.4172/2167-0870.1000144
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Efficacy of Gastrografin® Compared with Standard Conservative Treatment in Management of Adhesive Small Bowel Obstruction at Mulago National Referral Hospital

Abstract: Introduction-The treatment of adhesive small bowel obstruction is controversial, with both operative and non-operative management practiced in different centers worldwide. Non-operative management is increasingly getting popular, though operative rates still remain high. A study to compare the efficacy of an oral water-soluble medium (Gastrografin ® ) with standard conservative management, both non-operative methods, in the management of this condition was conducted in a tertiary Sub Saharan hospital.

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Cited by 8 publications
(8 citation statements)
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“…In addition, patients who did not show any improvement after 5 days underwent surgery. In a previous study [ 18 ], similar surgery was introduced to treat ASBO. For both groups, we tracked the time to resolution of adhesive small intestine obstruction (ASIO) with restored flatus and bowel motion, which is the time elapsed between initiation of treatment and first bowel action, and length of hospital stay (in hours, calculated from the time of hospital admission to resolution of intestinal obstruction).…”
Section: Methodsmentioning
confidence: 99%
“…In addition, patients who did not show any improvement after 5 days underwent surgery. In a previous study [ 18 ], similar surgery was introduced to treat ASBO. For both groups, we tracked the time to resolution of adhesive small intestine obstruction (ASIO) with restored flatus and bowel motion, which is the time elapsed between initiation of treatment and first bowel action, and length of hospital stay (in hours, calculated from the time of hospital admission to resolution of intestinal obstruction).…”
Section: Methodsmentioning
confidence: 99%
“…Cochrane risk of bias assessment of the RCTs revealed few issues with randomization, deviation from the intended treatment and having all the outcome data available for analysis (Table 1). [17][18][19][20][21][22][23][24][25][26][27] Most of the RCTs lacked protocols specifying exactly what treatments (such as when surgery should be performed) were rendered after WSC was administered or what criteria were used to determine hospital discharge.…”
Section: Cochrane Risk Of Bias Analysis For Rcts and Additional Quali...mentioning
confidence: 99%
“…Only 1 RCT was double blinded, 22 with the remainder being nonblinded. Two RCTs described concealment methods, 22,23 and 5 listed study dropouts and withdrawals. 17,19,[21][22][23]…”
Section: Cochrane Risk Of Bias Analysis For Rcts and Additional Quali...mentioning
confidence: 99%
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“…6 Over the last 2 decades, water-soluble contrast agents (ie, Gastrografin and Cystografin) have been used successfully in the nonoperative management of ASBO in the adult population. [7][8][9] Transit of contrast into the colon is of diagnostic benefit relative to a complete versus partial bowel obstruction, and therefore is highly predictive of the success with nonoperative management of ASBO. A lack of contrast in the colon during the 24-hour challenge period thereby enables early prediction of those patients who will fail conservative management and allows for earlier surgical intervention.…”
mentioning
confidence: 99%