Efficacy of Gastrosis No.1 compound on functional dyspepsia of spleen and stomach deficiency-cold syndrome: A multi-center, double-blind, placebo-controlled clinical trial

Zhang, Shengsheng; Zhao, Luqing; Wang, Hongbing; Wu, Bing; Chui-jie, Wang; Huang, Suiping; Shen, Hong; Wei, Wei; Lai, Yaoliang

doi:10.1007/s11655-013-1503-x

Cited by 18 publications

(12 citation statements)

References 13 publications

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“…The studies published between 1991 and 2019 were included. Patients had FD, [15][16][17][18][19][20][21][22]13,14,[23][24][25][26][27][28][29][30][31][32] and constipation [56][57][58][59][60][61][62] in 19, 23 and 7 trials respectively. More than 33 different kinds of herbal formulae were tested in the included trials.…”

Section: Resultsmentioning

confidence: 99%

“…Literature searches identified 3782 potentially relevant titles after elimination of duplicates. After review of the abstracts, 121 full‐text publications were assessed, of which 50 studies were included in this review, involving a total of 7396 participants. As two of the studies shared the same group of patients with two aspects of results reported, so their data was abstracted as one, resulting in totally 49 trials for analysis.…”

Section: Resultsmentioning

confidence: 99%

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Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Tan

Gwee

Tack

et al. 2019

J of Gastro and Hepatol

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Background and Aims The efficacy of herbal medicines (HMs) for functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS), functional dyspepsia (FD) and functional constipation (FC) is controversial. A systematic review with meta‐analysis was conducted to determine their effectiveness for FGIDs. Methods We searched the following electronic databases till July 2019 with English language restriction: The Cochrane Library, EMBASE and PUBMED. Randomized double‐blind controlled trials of HMs compared with placebo or conventional pharmacological drugs for adult FGIDs patients were included. Results In total, 49 trials involving 7396 participants with FGIDs were included. The risk of bias was low in 9, unclear in 36, and high in 4 trials. More than 33 different herbal formulae were tested. HMs demonstrated statistically significant benefits for symptom improvement compared with placebo in 46 trials (RR = 1.67, 95% CI 1.48–1.88). When compared with conventional pharmacological therapy in 5 trials, HMs were found to be non‐inferior (RR = 1.10, 95% CI 1.03–1.18). The number of trials with regards to FD, IBS and FC were 19, 23 and 7 respectively. Subgroup analysis found that HMs were better than placebo in alleviating symptoms for FD (RR = 1.50, 95% CI 1.32–1.69), IBS (RR = 1.62, 95% CI 1.32–1.97) and FC (RR = 3.83, 95% CI 2.26–6.50). HMs tended to have more patients with adverse events than placebo, but similar to conventional pharmacological drugs. Conclusions Our findings provide a positive signal for HMs as a potentially well‐tolerated and effective treatment for FGIDs, deserving further examination in high‐quality trials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Tan

Gwee

Tack

et al. 2019

J of Gastro and Hepatol

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“…Traditional Chinese Medicine (TCM) is an effective alternative treatment for FD [8][9][10][11][12][13][14][15][16]. According to TCM, FD is divided into different syndromes based on the clinical symptoms and signs, among which "spleen-deficiency and qi-stagnation" is the most common one [17].…”

Section: Introductionmentioning

confidence: 99%

Sini‐San Regulates the NO‐cGMP‐PKG Pathway in the Spinal Dorsal Horn in a Modified Rat Model of Functional Dyspepsia

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The present study investigated the effect of Chinese medicine Sini-San (SNS) on visceral hypersensitivity in a rat model of functional dyspepsia (FD), and it explored related underlying mechanisms. The rat model of FD was developed by combining neonatal iodoacetamide (IA) treatment and adult tail-clamping. After SNS treatment, the behavior and electromyographic testing were performed to evaluate the visceromotor responses of rats to gastric distention. Immunofluorescence was used to detect the distribution of iNOS-positive cells in the spinal dorsal horn, while the real-time quantitative PCR and western blot were used for detection of the gene expression of c-fos, iNOS, and GABAb and protein levels of iNOS and GABAb in the spinal dorsal horn, respectively. The protein concentration of cGMP and PKG proteins in the spinal dorsal horn were quantified by enzyme-linked immunosorbent assay. In this study, SNS treatment significantly reduced the behavioral score and electromyographic response to graded intragastric distension pressure. The middle-dose of SNS treatment significantly reduced the distribution of iNOS-positive cells in the spinal dorsal horn of FD model rats. The gene expression of c-fos, iNOS, and GABAb and the protein contents of iNOS, GABAb, cGMP, and PKG in the spinal dorsal horn of FD model rats were restored to a normal level by middle-dose of SNS treatment. Our results suggest that Sini-San may alleviate the visceral hypersensitivity in FD model rats via regulation of the NO/cGMP/PKG pathway in the spinal dorsal horn.

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“… 30 , 31 Some herbal TCM preparations have been shown to have benefit for functional dyspepsia. 32 - 34 Chinese herbal remedies, such as modified Xiao-yao-san and Modified Liu-Jun-Zi decoction might be effective in the treatment of functional dyspepsia. 35 , 36 With regard to TCM treatment for disorders of menstruation, there is some evidence supporting Chinese herbal medicine and acupuncture in treating primary dysmenorrheal.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Traditional Chinese Medicine Use in Pediatric Cancer Patients: A Nationwide, Retrospective, Taiwanese-Registry, Population-Based Study

et al. 2016

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Background. Large-scale surveys of complementary traditional Chinese medicine (TCM) use in pediatric cancer patients are lacking. The aim of our study was to investigate the use of TCM in pediatric cancer patients. Methods. We analyzed cancer patients younger than 18 years (n = 12 965) who were registered in the National Health Insurance Research Database in Taiwan between 2001 and 2011. Patients were categorized into TCM or non–TCM users based on their use of TCM. Results. In Taiwan, 8086 (62.4%) children with cancer sought TCM treatment at some point. Children in older age groups, including school-aged children and adolescents, were more likely to use TCM. There was no significant difference in the distributions of gender and urbanization. The 3 most common diseases for which TCM users visited the clinic were neoplasm (33.2%), respiratory system disease (32.9%), and infectious disease (8.86%). The most commonly utilized TCM therapy was Chinese herbal remedies. Patients who had comorbid conditions such as allergic rhinitis, dyspepsia, disorders of menstruation, and disease of the musculoskeletal system and connective tissue tended to visit TCM clinics. Conclusions. Adjunctive TCM use is not low in Taiwanese children with cancer. Further studies to investigate the efficacy and safety of TCM in children with cancer are warranted.

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Efficacy of Gastrosis No.1 compound on functional dyspepsia of spleen and stomach deficiency-cold syndrome: A multi-center, double-blind, placebo-controlled clinical trial

Abstract: CHM Gastrosis No.1 compound was effective and safe in the treatment of functional dyspepsia with Spleen and Stomach deficiency-cold syndrome.

Cited by 18 publications

References 13 publications

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Sini‐San Regulates the NO‐cGMP‐PKG Pathway in the Spinal Dorsal Horn in a Modified Rat Model of Functional Dyspepsia

Characteristics of Traditional Chinese Medicine Use in Pediatric Cancer Patients: A Nationwide, Retrospective, Taiwanese-Registry, Population-Based Study

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