Efficacy of Generic Drug Wartocid® (Imiquimod 5% Cream for External Use) in Anogenital Warts Treatment

Abstract

Abstract. Aim. To evaluate the efficacy and safety of the generic drug Wartocid ® (Imiquimod cream 5% for external use) in patients with external anogenital (venereal) warts (AGW). Materials and methods. The single-blind comparative, randomized, placebo-controlled clinical trial included 50 women aged 18 to 60 with an established clinical diagnosis of AGW in the vulva and perianal region. Patients in group 1 received placebo cream for external use, while patients in group 2 received therapy with Wartoсid in a daily dose of 10 mg cream/cm 2 of skin area. The drug was applied every other day until the complete disappearance of AGW, but in any case, not more than 16 weeks. A follow-up was carried out for 4 more weeks. The study evaluated the dynamics of subjective and objective symptoms, the presence and the frequency of relapses, and the percentage of full treatment of AGW. Main results. Treatment with Wartoсid resulted in a complete cure of AGW in 16% of patients, and a reduction in the focus area of AGW in 36% of patients. Against the background of the placebo no dynamics of the disease were reached. Neither serious adverse events nor clinically significant changes in blood tests, urine or serum biochemical parameters in any of the patients who received treatment with Wartoсid were observed. Conclusion. The generic drug Wartocid has been proved to be effective and safe for AGW treatment and its effectiveness is similar to the original drug Aldara ® (Imiquimod cream 5% for external use). Резюме. Цель. Оценка эффективности и безопасности воспроизведенного препарата Вартоцид ® (Имихимод крем 5% для наружного применения) у пациентов с наружными аногенитальными (венерическими) боро-давками (АГБ). Материалы и методы. Простое слепое сравнительное рандомизированное плацебо-контро-лируемое клиническое исследование включало 50 женщин в возрасте от 18 до 60 лет с установленным кли-ническим диагнозом АГБ в вульве и перианальном регионе. Пациенты в группе 1 получали плацебо-крем для наружного применения, тогда как пациенты в группе 2 получали терапию Вартоцидом в суточной дозе 10 мг крема/см 2 области кожи. Препарат применялся через день до полного исчезновения АГБ, но в любом

Topically applied treatments for external genital warts in nonimmunocompromised patients: a systematic review and network meta‐analysis

“…After removing duplicates and excluded studies, 41 RCTs (6371 patients) met the eligibility criteria (Fig. ) . Figure shows the network plots, depicting direct evidence between treatments.…”