Efficacy of ginger as antiemetic in children with acute gastroenteritis: a randomised controlled trial

Nocerino, Rita; Cecere, Gaetano; Micillo, Maria; Marco, G. De; Ferri, Pasqualina; Russo, M.; Bedogni, Giorgio; Canani, Roberto Berni

doi:10.1111/apt.16404

Cited by 20 publications

(14 citation statements)

References 36 publications

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“…They observed that both ginger and ondansetron reduced the frequency of vomiting; however, ginger was more effective than ondansetron. In this line, Nocerino et al 31 studied through a double-blind, randomized placebo-controlled trial the use of a preparation containing 47.4% (w/w) of ginger for the reduction of vomiting associated with acute gastroenteritis (AGE) in children; they found that the ginger preparation was effective in reducing vomiting in children with AGE. Also, Menon et al 32 in a clinical trial with 10 patients, compared the effectiveness of ibuprofen and dried ginger powder as alternative medicines for the management of pain and gingival inflammation following periodontal surgery; they observed no difference between ibuprofen and ginger in the reduction of pain and gingival inflammation.…”

Section: Overview Of the Investigated Clinical Trials And The Main Outcomes Of Ginger Bioactive Compoundsmentioning

confidence: 99%

Ginger: a systematic review of clinical trials and recent advances in encapsulation of its bioactive compounds

et al. 2022

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Section: Overview Of the Investigated Clinical Trials And The Main Outcomes Of Ginger Bioactive Compoundsmentioning

confidence: 99%

Ginger: a systematic review of clinical trials and recent advances in encapsulation of its bioactive compounds

et al. 2022

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“…The use of ginger as an antiemetic is well-known in China and is used in traditional Chinese medicine, where ginger is rich in curcumin, curcumin, gingerols, and curcuminoids ( Ahmed et al, 2021 ). These active substances influence gastrointestinal motility and promote gastric emptying, while they affect the central nervous system by mediating the 5-hydroxytryptamine-3 of 5-hydroxytryptamine (5-HT), reducing nausea and vomiting ( Nocerino et al, 2021 ). Marx et al (2017) conducted a double-blind randomized intervention with ginger in 51 patients, identifying less fatigue in the intervention group ( p = 0.006) from the three chemotherapy cycles, especially in the third cycle.…”

Section: Mitigation Of Adverse Drug Reactions To Parpi By Phytochemicalsmentioning

confidence: 99%

Natural phytochemicals prevent side effects in BRCA-mutated ovarian cancer and PARP inhibitor treatment

Wang

Gao

et al. 2022

Front. Pharmacol.

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Ovarian cancer is among the most common malignant tumors in gynecology and is characterized by insidious onset, poor differentiation, high malignancy, and a high recurrence rate. Numerous studies have shown that poly ADP-ribose polymerase (PARP) inhibitors can improve progression-free survival (PFS) in patients with BRCA-mutated ovarian cancer. With the widespread use of BRCA mutation and PARP inhibitor (PARPi) combination therapy, the side effects associated with BRCA mutation and PARPi have garnered attention worldwide. Mutations in the BRCA gene increase KEAP1-NRF2 ubiquitination and reduce Nrf2 content and cellular antioxidant capacity, which subsequently produces side effects such as cardiovascular endothelial damage and atherosclerosis. PARPi has hematologic toxicity, producing thrombocytopenia, fatigue, nausea, and vomiting. These side effects not only reduce patients’ quality of life, but also affect their survival. Studies have shown that natural phytochemicals, a class of compounds with antitumor potential, can effectively prevent and treat the side effects of chemotherapy. Herein, we reviewed the role of natural phytochemicals in disease prevention and treatment in recent years, including sulforaphane, lycopene, catechin, and curcumin, and found that these phytochemicals have significant alleviating effects on atherosclerosis, nausea, and vomiting. Moreover, these mechanisms of action significantly correlated with the side-effect-producing mechanisms of BRCA mutations and PARPi. In conclusion, natural phytochemicals may be effective in alleviating the side effects of BRCA mutant ovarian cancer cells and PARP inhibitors.

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“…A total of 33% of patients treated with ginger had resolution of vomiting after the first dose, compared to 13% in the placebo arm ( p = 0.003). The ginger product used was a liquid containing 10 mg of ginger extract per 20 drops (1% ginger by weight), given at a dose of 10 mg every 8 h until the resolution of vomiting [ 58 ].…”

Section: Gingermentioning

confidence: 99%

Herbal Approaches to Pediatric Functional Abdominal Pain

Cherry¹,

Blanchard

Chogle

et al. 2022

Children

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Chronic abdominal pain is one of the most common problems seen by both pediatricians and pediatric gastroenterologists. Abdominal-pain-related functional gastrointestinal disorders (AP-FGIDs) are diagnosed in children with chronic and recurrent abdominal pain meeting clinical criteria set forth in the Rome IV criteria. AP-FGIDs affect approximately 20% of children worldwide and include functional dyspepsia (FD), irritable bowel syndrome (IBS), functional abdominal pain (FAP), and abdominal migraine. IBS accounts for 45% of pediatric AP-FGIDs. The pathophysiology of functional abdominal pain involves an interplay of factors including early life events, genetics, psychosocial influences, and physiologic factors of visceral sensitivity, motility disturbance, altered mucosal immune function, and altered central nervous system processing. Treatment approaches are varied and can include dietary, pharmacologic, and complementary medicine interventions, as well as psychosocial support, depending on the many aspects of the disorder and the needs of the individual patient. There is a strong interest in complementary and integrative medicine approaches to pediatric pain from both patients, providers, and families. In this article, we discuss popular herbal treatments typically used in the field of complementary medicine to treat pediatric AP-FGIDs: peppermint oil, Iberogast®, cannabis, fennel, and licorice. While high-quality data are rather limited, studies generally show that these remedies are at least as effective as placebo, and are well tolerated with minimal side effects. We will need more placebo-controlled, double-blind, and unbiased prospective studies to document and quantify efficacy.

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Efficacy of ginger as antiemetic in children with acute gastroenteritis: a randomised controlled trial

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 20 publications

References 36 publications

Ginger: a systematic review of clinical trials and recent advances in encapsulation of its bioactive compounds

Ginger: a systematic review of clinical trials and recent advances in encapsulation of its bioactive compounds

Natural phytochemicals prevent side effects in BRCA-mutated ovarian cancer and PARP inhibitor treatment

Herbal Approaches to Pediatric Functional Abdominal Pain

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