Efficacy of glutamine-enriched enteral nutrition in an experimental model of mucosal ulcerative colitis

Fujita, Tetsuji; Sakurai, Katsunobu

doi:10.1002/bjs.1800820611

Cited by 48 publications

(25 citation statements)

References 22 publications

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“…Glutamine also plays a central role in colonocyte nutrition and integrity. 30,31 In addition, the preventive effects of diets supplemented with glutamine on intestinal integrity were reported during experimental severe colitis, [32][33][34] although no therapeutic effect of glutamine on colitis was reported. 35 In our study the oral administration of glutamine for 2 days after the pathogenesis of colitis significantly decreased the histological score of colon tissue from DSStreated mice (Fig.…”

Section: Discussionmentioning

confidence: 97%

GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium

Shiomi

Nishiumi

Ooi

et al. 2011

Inflammatory Bowel Diseases

101

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Section: Discussionmentioning

confidence: 97%

GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium

Shiomi

Nishiumi

Ooi

et al. 2011

Inflammatory Bowel Diseases

101

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“…Studies in animal models of inflammatory bowel diseases have indicated potentially beneficial effects of glutamine supplementation (Fujita & Sakurai, 1995;Ameho et al, 1997), but this may not be related simply to an improvement in the intestinal function and barrier. In animals and man, enteral or parenteral nutrition supplemented with glutamine is associated with improved lymphocyte function and antioxidant capacity compared to standard TPN (Furst et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Glutamine-enriched total parenteral nutrition in patients with inflammatory bowel disease

et al. 2005

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Background: Studies in animal models of inflammatory bowel disease (IBD) suggest that supplementation of total parenteral nutrition with glutamine (gln), a conditionally essential amino acid in catabolic conditions, increases gln plasma concentrations, reduces intestinal damage, improves nitrogen balance and may improve the course of the disease. However, human data supporting this assumption are missing. Methods: A total of 24 consecutive patients with an acute exacerbation of IBD (19 Crohn's disease; five ulcerative colitis) and scheduled for total parenteral nutrition (TPN) (47 days) were randomised. Parallel to a standardised anti-inflammatory therapy, the patients received either a TPN with 1.5 g/kg body weight of a standard amino acid or an isonitrogenic, isocaloric TPN with 1.2 g/kg body weight of a standard amino acid and 0.3 g/kg L-alanine-L-glutamine. Primary end points were gln plasma concentrations and intestinal permeability assessed by urinary lactulose and D-xylose ratio. Results: Gln plasma levels did not differ significantly in either group throughout the study. Intestinal permeability did not change within 7 days either with or without gln supplementation (D-lactulose/xylose ratio: 0.0170.05 (gln þ ) vs 0.0270.1 (glnÀ)). The observed changes in inflammatory and nutritional parameters, and also disease activity, length of TPN and hospital stay, were independent of glutamine substitution. Five (41%) patients in the gln þ group and three (25%) patients in the glnÀ group needed surgical intervention. Conclusion: Although limited by the sample size, these results do not support the hypothesis that glutamine substitution has an obvious biochemical or clinical benefit in patients with active IBD scheduled for total parenteral nutrition.

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“…The concentration of glutamine was chosen to match that used in previous similar studies [13,16,17] . The amount of food and water consumed by each animal was recorded each day (SDS-RM3A rat chow (Special Dietary Services, UK) and tap water) and animals receiving glutamine were pair-fed with animals in the control group.…”

Section: Methodsmentioning

confidence: 99%

Glutamine Improves Intestinal Barrier Function in Experimental Biliary Obstruction

White¹,

Hoper²,

Parks³

et al. 2005

Eur Surg Res

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Objective: To determine the effects of enteral administration of glutamine on intestinal barrier function in experimental biliary obstruction. Background: Extrahepatic biliary obstruction is associated with the failure of intestinal barrier function, allowing bacteria and other substances from the intestine to enter the circulation and initiate a systemic inflammatory response, causing impairment of multiple organs. The amino acid glutamine has been shown to improve intestinal barrier function in other conditions, but its effects in biliary obstruction have not been fully examined. Methods: This study examined the effects of enteral administration of glutamine on intestinal permeability and on bacterial translocation from the intestine in a rodent model of biliary obstruction. Results: Glutamine was shown to reduce intestinal permeability measured as percentage excretion of ¹⁴C 7 days after biliary obstruction (0.35 ± 0.03 vs. 0.56 ± 0.085% in controls, p = 0.028), and glutamine administration was also associated with a decreased incidence of bacterial translocation to extra-intestinal sites (p = 0.03). Radiolabelled bacterial studies also demonstrated reduced translocation of bacterial fragments to extra-intestinal sites in glutamine-treated animals (p = 0.01). There was also some evidence of decreased exposure to endotoxin, reduced systemic inflammation and increased bacterial killing by the immune system in glutamine-treated animals. Conclusions: Glutamine modulates intestinal permeability and reduces bacterial translocation in an animal model of experimental biliary obstruction and may increase bacterial killing by the immune system.

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Efficacy of glutamine-enriched enteral nutrition in an experimental model of mucosal ulcerative colitis

Cited by 48 publications

References 22 publications

GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium

GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium

Glutamine-enriched total parenteral nutrition in patients with inflammatory bowel disease

Glutamine Improves Intestinal Barrier Function in Experimental Biliary Obstruction

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