Efficacy of glycerol in preventing postoperative peritoneal adhesions

Ayşan, Erhan; Bektaş, Hasan; Kaygusuz, Arslan

doi:10.1111/j.1447-0756.2010.01168.x

Cited by 9 publications

(18 citation statements)

References 26 publications

(57 reference statements)

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“…Aysan et al evaluated flax seed oil and glycerol for effectiveness in preventing postoperative peritoneal adhesions in 2 separate studies, both of which found that flax seed oil and glycerol significantly decreased peritoneal adhesion formation [37,38]. Building on these studies, we evaluated the effectiveness of flax seed oil and glycerol in preventing post-thyroidectomy adhesions.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy

et al. 2014

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BackgroundWe evaluated the effects of local flax seed oil and glycerol application for reducing adhesion formation after thyroidectomy.Material/MethodWe randomly assigned 18 female Wistar albino rats (median weight: 275 g, median age: 4.5 mth) to 3 groups: 0.1 ml 0.9% NaCl, glycerol, and flax seed oil were sprayed in a perithyroidal area after thyroidectomy operation on all animals as anti-adhesive barriers. Rats were sacrificed on the postoperative 14th day and adhesions were evaluated macroscopically and microscopically.ResultsThe median macroscopic adhesion score was 3.0±0.0 in the 0.9% NaCl group, 1.33±0.52 in the glycerol group, and 1.67±0.53 in the flax seed oil group. The median histopathological fibrosis scores were 2.33±0.82, 0.67±0.52, and 0.83±0.75, respectively. Both glycerol and flaxseed oil group macroscopic and microscopic scores were significantly lower than the 0.9% NaCl group (p<0.05). There was no significant difference among the groups (p>0.05).ConclusionsGlycerol and flax seed oil both decrease the incidence of post-thyroidectomy adhesion in rats, but glycerol is more effective.

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Section: Discussionmentioning

confidence: 99%

Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy

et al. 2014

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“…The viscous liquids used were soybean oil (Soya yagi, Arifoglu Co.), octyl methoxycinnamate (Vazelin sivi, Galenik Ecza Co.), flax seed oil (Keten yagi, Arifoglu Co.), aloe vera gel (Natural Aloe Vera Gel, Arifoglu Co.), and glycerol (Gliserin, Adora Kimya Co.) [6–10]. …”

Section: Methodsmentioning

confidence: 99%

“…In the absence of adhesions, intraperitoneal 0.1 mL of the following sterile viscous liquids was injected interperitoneally in five subgroups:Group 2.1 ( n = 10): soybean oil [6],Group 2.2 ( n = 10): octyl methoxycinnamate [7],Group 2.3 ( n = 10): flax seed oil [8],Group 2.4 ( n = 10): aloe vera gel [9],Group 2.5 ( n = 10): glycerol [10]. …”

Section: Methodsmentioning

confidence: 99%

“…Viscous liquids studied were ricini, zingiber, daphne, orange, sesame, opium, jasmine, chamomile, hazelnut, eucalyptus, mint, myrtle, honey, and soybean oils, as well as octyl methoxycinnamate, flax seed oil, aloe vera gel, and glycerol. Only the last five have been shown to prevent PPAs [6–10]. In addition to determining the effects of these liquids on preexisting PPAs, we assessed their ability to prevent peritoneal trauma.…”

Section: Introductionmentioning

confidence: 99%

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New and Simple Approach for Preventing Postoperative Peritoneal Adhesions: Do not Touch the Peritoneum without Viscous Liquid—A Multivariate Analysis

Ayşan

Bektaş

Ersöz

et al. 2012

Obstetrics and Gynecology International

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Background. Postoperative peritoneal adhesions (PPAs) are an unsolved and serious problem in abdominal surgery. Method. Viscous liquids of soybean oil, octyl methoxycinnamate, flax oil, aloe vera gel, and glycerol were used in five experiments, using the same methodology for each. Liquids were applied in the peritoneal cavity before and after mechanical peritoneal trauma. Results were evaluated by multivariate analysis. Results. Compared with the control group, macroscopic and microscopic adhesion values before (P < .001) and after (P < .05) application of viscous liquids significantly reduced PPAs. Values were significantly lower when liquids were applied before rather than after peritoneal trauma (P < .0001). Discussion. Viscous liquids injected into the peritoneal cavity before or after mechanical peritoneal trauma decrease PPA. Injection before trauma was more effective than after trauma. In surgical practice, PPA formation may be prevented or decreased by covering the peritoneal cavity with an appropriate viscous liquid before abdominal surgery.

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“…These adhesions can be induced by infection, inflammation, ischemia, and surgical injury and are the leading cause of pelvic pain, infertility, and bowel obstruction. The mechanisms underlying the predisposition to form adhesions and their site specificity are unknown [2–4]. Intra-abdominal adhesions are believed to develop as a result of ischemia and trauma to the serosal surface of bowel or peritoneum [4–6].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Antivascular Endothelial Growth Factor on the Development of Adhesion Formation in Laparotomized Rats: Experimental Study

Başbuğ

Bülbüller

Camcı

et al. 2011

Gastroenterology Research and Practice

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Aims. This study determined the effects of a single dose of bevacizumab, an antiangiogenic recombinant monoclonal antibody that specifically targets vascular endothelial growth factor (VEGF), on adhesion formation in the rat cecal abrasion model. Methodology. Thirty female Wistar albino rats (200–224 g) were divided into three groups. All rats underwent laparotomy at which time cecal wall abrasion and abdominal wall injuries were induced. Group I (control) underwent only the abrasion procedure; Groups II and III received saline or bevacizumab intraperitoneally, respectively, following the abrasion. The rats were killed on postoperative day 7, and the severity of adhesions was evaluated, together with histopathological fibrosis parameters and immunohistochemical staining to identify the VEGF receptor. Results. The mean adhesion severity score in Groups I–III was 2.5 ± 0.52, 2.4 ± 0.69, and 0.7 ± 0.82, respectively; the score in Group III was significantly lower than that in Groups I (P < 0.001) and II (P < 0.001). In the histopathological evaluation, the mean fibrosis score in Group III was significantly lower that the scores in Groups I (P < 0.001) and II (P < 0.001). VEGF staining of the adhesion areas in Group III was significantly lower than that in Groups I (P < 0.001) and II (P < 0.001). Conclusion. Bevacizumab decreases adhesion formation following laparotomy in rats by blocking VEGF receptor occupancy.

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Efficacy of glycerol in preventing postoperative peritoneal adhesions

Cited by 9 publications

References 26 publications

Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy

Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy

New and Simple Approach for Preventing Postoperative Peritoneal Adhesions: Do not Touch the Peritoneum without Viscous Liquid—A Multivariate Analysis

The Effect of Antivascular Endothelial Growth Factor on the Development of Adhesion Formation in Laparotomized Rats: Experimental Study

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