Efficacy of grape seed extract gel in the treatment of chronic periodontitis: A randomized clinical study

Rayyan, Mohammad; Terkawi, Tammam; Abdo, Hajer; Azim, Dalia Abdel; Khalaf, Asseel; AlKhouli, Zenab; Meziad, Maha; Alshamma'a, Marwa; Naim, Horiyah Abu

doi:10.1111/jicd.12318

Cited by 13 publications

(8 citation statements)

References 17 publications

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“…Incorporation of catechin in dentifrice, from the green tea extract has reduced the periodontal inflammation 47 while catechin from the grape seed extract, applied in a gel form into the periodontal pocket resulted in improvement of the plaque and gingival index. However, it did not effect the periodontal pocket depth significantly 48 .…”

Section: Periodontal Diseasementioning

confidence: 81%

Clinical Applications of Catechin in Dentistry: A Review

Azmi

Sockalingam

Said

et al. 2020

Journal of Natural Remedies

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Studies on plant and food phytochemistry and its potential benefits to human health are becoming the focus of the research community. Researchers are turning to alternatives drugs in treating human diseases using natural products from plants and foods. Polyphenols are one of the largest groups in the plant family and consist of many subgroups. One of them is catechin, which is generally acknowledged to be part of a compound in tea. Over the years, investigations have shown that catechin has anti-oxidant, anti-inflammatory and antibacterial properties. In dentistry, documented evidence have shown the use of catechin in treatment of dental caries, periodontal disease, pulp pathology, and oral cancer. Other crucial areas of research include advancements in dental material incorporated with catechin. This review article explores the current studies on the potential use of catechin in dentistry.

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Section: Periodontal Diseasementioning

confidence: 81%

Clinical Applications of Catechin in Dentistry: A Review

Azmi

Sockalingam

Said

et al. 2020

Journal of Natural Remedies

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“…The sample size was determined (N=15) at a power of 80% with the level of significance set at P <0.05 using a formula [12]. The study was carried out on 45 subjects who were randomly divided into Groups-A, B, C, containing 15 subjects each out of which 9 samples were lost due to follow-up during the COVID -19 pandemic.…”

Section: Sample Size Calculation and Methodologymentioning

confidence: 99%

Antimicrobial efficacy of grape seed extract in terminating the ramifications of plaque microorganisms: a randomized control study

Koregol

Kalburgi

Puttarevanna

et al. 2022

Medicine and Pharmacy Reports

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inhibiting interstitial and extracellular collagenase, thus having the potential to reduce the progression of periodontitis. Here we compare and evaluate the aerobic and anaerobic microorganism’s CFUs (colony forming units) in plaque samples of Group A, Group B, Group C and severity of periodontal disease on day 0 and 7. Method. Forty-five subjects in age range 18-30 years were selected among undergraduate students and randomly divided into Group A: 15, 2% grape seed extract mouthwash (GSE), Group B: 15, 0.2% chlorhexidine mouthwash (CHX) and Group C: 15, distilled water (control). The supragingival plaque was collected into transport media. Kruskal Wallis test followed by Mann Whitney test was used to compare the mean CFUs [x103] of microorganisms and severity of periodontal disease was compared, by clinical parameters among all groups on day 0 and 7. Results. There was a significant difference concerning mean scores of all clinical parameters [P<0.001] and mean CFUs of microorganisms between 3 study groups [P=0.005] at 7 days post-intervention period. Intragroup comparison, mean scores were significantly reduced on day 7 as compared to day 0 at [P<0.001] in Group A and B, but no significant difference was noted with Group C. Conclusion. Intervention with GSE mouthwash showed a positive effect on reducing CFUs in the plaque when compared with the control group. GSE group also showed similar results in reducing CFUs in plaque when compared to CHX group, thereby demonstrating the agent’s antimicrobial efficacy, therapeutic effect and its potential usefulness in controlling plaque and periodontal diseases.

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“…Rayyan et al (22) stated that subgingival application of a formulated 2% mucoadhesive grape seed extract gel improved the PI and gingival index, but there was no significant enhancement in PD.…”

Section: Methodsmentioning

confidence: 99%

The efficacy of herbal medicine on gingival and periodontal diseases: a review

Baghizadeh¹,

Aghayan

Rahati³

et al. 2021

J Res Dent Maxillofac Sci

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Background and Aim:The most common etiology of gingivitis is accumulation of bacterial plaque. Complete removal of microbial plaque by mechanical procedures is not possible in some cases; for example, aged and disabled patients might not be capable of removing the bacterial plaques properly. Also, chemical mouthwashes have some adverse effects. Therefore, finding a new treatment approach would be helpful. The global focus on the use of herbal medicine for treatment of different health conditions is on the rise. The present study aimed at searching and collecting scientific evidence regarding medicinal herbs to treat gingivitis and periodontitis. Materials and Methods: In this review, an electronic search of the literature was conducted through PubMed, Scopus, Google Scholar, and Wiley online library databases. Studies were considered for inclusion if they evaluated medicinal herbs affecting gingival and periodontal inflammation or periodontal pathogens. Totally, 197 full-text articles were evaluated and finally, based on the inclusion criteria, 22 articles were selected. Results: There are various medical herbs with antibacterial and anti-inflammatory properties, which can significantly decrease gingival and periodontal inflammation, bleeding on probing (BOP), plaque index (PI), probing depth (PD) and the count of major periodontal pathogens, and promote clinical attachment gain. Conclusion:The introduced herbal products could be an efficient and safe alternative to chemical products.

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Efficacy of grape seed extract gel in the treatment of chronic periodontitis: A randomized clinical study

Abstract: The subgingival application of the formulated 2% mucoadhesive GSE gel showed significant improvement in the PI and GI only.

Cited by 13 publications

References 17 publications

Clinical Applications of Catechin in Dentistry: A Review

Clinical Applications of Catechin in Dentistry: A Review

Antimicrobial efficacy of grape seed extract in terminating the ramifications of plaque microorganisms: a randomized control study

The efficacy of herbal medicine on gingival and periodontal diseases: a review

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