Efficacy of hysteroscopy in improving reproductive outcomes of infertile couples: a systematic review and meta-analysis

Sardo, Attilio Di Spiezio; Carlo, Costantino Di; Minozzi, Silvia; Spinelli, Marialuigia; Pistotti, Vanna; Alviggi, Carlo; Placido, Giuseppe De; Nappi, Carmine; Bifulco, Giuseppe

doi:10.1093/humupd/dmw008

Cited by 124 publications

(72 citation statements)

References 67 publications

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“…In recent years, many reports have discussed noninvasive techniques that enable the monitoring of embryos' development without moving them from incubators, using time-lapse imaging, to increase the precision and sensitivity of embryo selection [30][31][32]. Besides the above evaluation criteria, the role of the clinician performing the transfer and the patient's inherent condition (endometrial receptivity) are additional key elements in determining the success of implantation, and should not be ignored [33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Over Ten-Cell Good Embryo Transfers on Day Three have Equivalent Clinical Outcomes with Those of Eight-Cell Embryos in Female Patients Aged ≤35 Years: A Retrospective Cohort Study

Zhao

Liu

et al. 2019

Gynecol Obstet Invest

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Background/Aim: To compare the clinical outcomes between > 10- and 8-cell good quality embryos on day 3. Methods: A retrospective study of a cohort of 459 patients was included in the fresh embryo transfer (ET) cycle group from January 2009 to April 2016. In this group, 2 good quality embryos on day 3, were transferred on corresponding dates, in 75 patients (> 10-cell embryos), and in 384 patients (8-cell embryos). Seven hundred and forty four patients, with 1 blastocyst transferred derived from > 10-cell (n = 183) or 8-cell (n = 561) good quality embryos on day 3, were assigned in the frozen ET (FET) group. Results: In the ET group, the clinical pregnancy and live birth rates of the > 10-cell transfer patients were comparable with those of the 8-cell transfer group (62.67 vs. 69.27%, 60.00 vs. 59.90%, respectively); however, the miscarriage rate of > 10-cell transfers was significantly lower than that of 8-cell transfers (4.26 vs. 13.53%, p < 0.05). In the FET group, there were no statistically significant differences found in the clinical pregnancy, live birth, and miscarriage rates between one > 10-cell-derived and one 8-cell-derived blastocyst transfers (71.04 vs. 65.78%, 59.02 vs. 54.19%, and 16.92 vs. 17.62%, respectively). Conclusions: The results suggested that > 10- and 8-cell, good quality embryos on day 3, had comparable viability and clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Over Ten-Cell Good Embryo Transfers on Day Three have Equivalent Clinical Outcomes with Those of Eight-Cell Embryos in Female Patients Aged ≤35 Years: A Retrospective Cohort Study

Zhao

Liu

et al. 2019

Gynecol Obstet Invest

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“…Currently, limited evidence supports this proposal. Recent meta-analyses [8788] concerning hysteroscopy or artificial endometrial injuries in ART have reported significant improvements in the clinical pregnancy rate. However, this possibility has yet to be supported by well-designed RCTs, so this proposal must remain hypothetical for the time being.…”

Section: Treatment Of Cementioning

confidence: 99%

Chronic endometritis and infertility

Park

Kim

Yoon

et al. 2016

Clin Exp Reprod Med

150

111

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Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%. Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease. However, the relationship between CE and infertility-related conditions such as repeated implantation failure and recurrent miscarriage has recently emerged as an area of inquiry. In this study, we reviewed the literature on the pathophysiology of CE and how it may be associated with infertility, as well as the literature regarding the diagnosis and treatment of CE. In addition, we discuss the value of hysteroscopic procedures in the diagnosis and treatment of CE.

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“…Infertility affects ~15% of couples who wish to have children and half of these cases are associated with male‐related factors 1. Genetic causes of azoospermia include chromosomal abnormalities, Y chromosome microdeletions, and specific mutations or deletions of several Y chromosomal genes 2, 3.…”

Section: Introductionmentioning

confidence: 99%

Human male infertility and its genetic causes

Miyamoto

Minase

Shin

et al. 2017

Reprod Medicine & Biology

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BackgroundInfertility affects about 15% of couples who wish to have children and half of these cases are associated with male factors. Genetic causes of azoospermia include chromosomal abnormalities, Y chromosome microdeletions, and specific mutations/deletions of several Y chromosome genes. Many researchers have analyzed genes in the AZF region on the Y chromosome; however, in 2003 the SYCP3 gene on chromosome 12 (12q23) was identified as causing azoospermia by meiotic arrest through a point mutation.MethodsWe mainly describe the SYCP3 and PLK4 genes that we have studied in our laboratory, and add comments on other genes associated with human male infertility.ResultsUp to now, The 17 genes causing male infertility by their mutation have been reported in human.ConclusionsInfertility caused by nonobstructive azoospermia (NOA) is very important in the field of assisted reproductive technology. Even with the aid of chromosomal analysis, ultrasonography of the testis, and detailed endocrinology, only MD‐TESE can confirm the presence of immature spermatozoa in the testes. We strongly hope that these studies help clinics avoid ineffective MD‐TESE procedures.

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Efficacy of hysteroscopy in improving reproductive outcomes of infertile couples: a systematic review and meta-analysis

Abstract: Robust and high-quality RCTs are still needed before hysteroscopy can be regarded as a first-line procedure in all infertile women, especially during the basal clinical assessment of the couple, when assisted reproductive treatment is not indicated yet.

Cited by 124 publications

References 67 publications

Over Ten-Cell Good Embryo Transfers on Day Three have Equivalent Clinical Outcomes with Those of Eight-Cell Embryos in Female Patients Aged ≤35 Years: A Retrospective Cohort Study

Over Ten-Cell Good Embryo Transfers on Day Three have Equivalent Clinical Outcomes with Those of Eight-Cell Embryos in Female Patients Aged ≤35 Years: A Retrospective Cohort Study

Chronic endometritis and infertility

Human male infertility and its genetic causes

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