Efficacy of Aloe vera, Ananas comosus, and Sansevieria masoniana Cream on the Skin Wound Infected with MRSA

Abstract

The tropical area has a lot of herbal medicines such as Aloe vera (AV), Ananas comosus (AC), and Sansevieria masoniana (SM). All the three have a unique potential effect as an antibacterial and wound-healing promoter. The aim of this study is to explore the role of AV, AC, and SM on the skin wound infected with methicillin-resistant Staphylococcus aureus (MRSA). Forty-five adult female Sprague Dawley rats weighing 250–300 grams were divided into 5 groups. All the groups were exposed to two round full-thickness punch biopsy and infected with MRSA. The group C was the control group/untreated; group BC was treated with base cream/without extract; group AV was treated with 75% AV cream; group AC was treated with 75% AC cream, and group SM was treated with 75% SM cream. The wounds were observed on days 5, 10, and 15. The healing of skin wounds was measured by a percentage of closure, skin tensile strength, and histopathology. The result showed that AV, AC, and SM have a similar potential effect on healing in the wound that was infected with MRSA compared to the groups C and BC (P < 0.05). It shows that all the three herbal formulations can be used as the alternative therapy to the wound infected with MRSA.

In Vitro Antibacterial Activity of Ethanolic Extract Derived from Leaves of Sansevieria Aethiopica Thunb. (Asparagaceae)

“…The microbial growth inhibition capacity relies on the rich variety of phytochemicals including carbohydrates, saponin, flavonoids, phenols, alkaloid, anthocyanin and cyanine, glycosides, proteins, and phytosterols . Prakoso et al (2018) have explored the role of Aloe vera (L.) Burm.f. (AV), Ananas comosus (L.) Merr.…”

“…The result showed that AV, AC, and SM have a similar potential effect on healing in the wound that was infected with MRSA compared to the groups C and BC (P <0.05). The study of Prakoso et al (2018) proved that AV, AC, and SM are widely used as traditional medicine and have a potential role in activating cluster of differentiation 8 [CD8 + , a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR)] to infiltrate the wound tissue as the mechanism to eliminate MRSA infection (Wu and Xu, 2014). As T-cells are cytotoxic, CD8 + plays an important role not only in controlling the infection but also in eliminating the infected cells (Prakoso et al, 2014).…”

Unripe Rind and Pulp of Ananas comosus Accelerate Wound Healing in Diabetic Wistar Rat

“…The results of the phytochemical screening were similar to those of Prakoso et al [24] who demonstrated that A. comosus cream promoted healing in wounds infected with methicillin resistant Staphylococcus aureus. The global annual production of pineapple is estimated to be over 14 million tons [25] and the rind constitutes 10% of the weight of the fruit [26]. This implies that pineapple contributes significantly to agricultural waste worldwide and may thus have a negative impact on the environment.…”

Analisis percepatan penyembuhan luka pada ibu post sectio sesarea multipara dengan pemberian olahan nanas (ananas comosus (l.merr) comosus)

“…Buah nanas dapat ditemukan pada hampir seluruh belahan dunia dan mempunyai banyak kandungan bermanfaat. Nanas mengandung enzim bromelain yang berguna untuk anti-inflamasi (damanik, 2019) (Prakoso, Setiyo Rini and Wirjaatmadja, 2018). Enzim ini dapat mempercepat pemulihan saat terjadi luka atau peradangan (Rahayu, Agustina and Tjandrawinata, 2017).…”