Efficacy of Itraconazole in the Prophylactic Treatment of Pityriasis (Tinea) Versicolor

Faergemann, Jan; Gupta, Aditya K.; Mofadi, A. Al; Abanami, A.; Shareaah, A. Abu; Marynissen, G.

doi:10.1001/archderm.138.1.69

Cited by 46 publications

(26 citation statements)

References 20 publications

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“…179,180 Oral itraconazole may be effective in the prophylaxis of pityriasis versicolor. Faergemann et al 181 reported that in a 6-month study, itraconazole (400 mg) administered once monthly was effective in the prophylaxis against the recurrence of pityriasis versicolor, in comparison with placebo. Ketoconazole has also been used effectively in prophylactic regimens for pityriasis versicolor, with either single monthly doses of 400 mg or 200 mg once daily for the first 3 days of each month.…”

Section: Treatmentmentioning

confidence: 99%

Skin diseases associated with Malassezia species

Gupta

Batra

Bluhm

et al. 2004

Journal of the American Academy of Dermatology

441

359

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Section: Treatmentmentioning

confidence: 99%

Skin diseases associated with Malassezia species

Gupta

Batra

Bluhm

et al. 2004

Journal of the American Academy of Dermatology

441

359

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“…Follow‐up for up to 11 months showed a low rate of recurrence in patients receiving prophylactic treatment. Itraconazole 400 mg one dose (four capsules of 100 mg each) given once a month for 6 months has been demonstrated to be significantly more effective than placebo 220 …”

Section: Treatmentmentioning

confidence: 99%

Pityriasis versicolor

Gupta

Bluhm

Summerbell

2002

Acad Dermatol Venereol

153

168

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“…Dermatologists may consider prophylactic treatment for patients who experience frequent relapses of PV. Single‐dose itraconazole 400 mg administrated once a month for 6 months is reportedly effective as a prophylactic treatment …”

Section: Pityriasis Versicolormentioning

confidence: 99%

Malassezia species and their associated skin diseases

Harada

Saito

Sugita

et al. 2015

The Journal of Dermatology

120

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Malassezia spp. are lipophilic fungi that occur on all skin surfaces of humans and animals as commensal and pathogenic organisms. In the 2000s, several new species were added to the Malassezia genus by Japanese researchers. The genus Malassezia now includes 14 species of basidiomycetous yeast. Culture-independent molecular analysis clearly demonstrated that the DNA of Malassezia spp. was predominantly detected in core body and arm sites, suggesting that they are the dominant fungal flora of the human body. Malassezia spp. have been implicated in skin diseases including pityriasis versicolor (PV), Malassezia folliculitis (MF), seborrheic dermatitis (SD) and atopic dermatitis (AD). While Malassezia spp. are directly responsible for the infectious diseases, PV and MF, they act as an exacerbating factor in AD and SD. The fatty acids generated by Malassezia lipase can induce inflammation of the skin, resulting in development of SD. Patch and serum immunoglobulin E tests revealed that AD patients were hypersensitive to Malassezia. However, these findings only partially elucidated the mechanism by which Malassezia spp. induce inflammation in the skin; understanding of the pathogenetic role of Malassezia spp. in SD or AD remains incomplete. In this article, the latest findings of Malassezia research are reviewed with special attention to skin diseases.

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Efficacy of Itraconazole in the Prophylactic Treatment of Pityriasis (Tinea) Versicolor

Cited by 46 publications

References 20 publications

Skin diseases associated with Malassezia species

Skin diseases associated with Malassezia species

Pityriasis versicolor

Malassezia species and their associated skin diseases

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