Efficacy of levamisole and <i>Tarantula cubensis</i> venom for the treatment of bovine cutaneous papillomatosis

Çam, Y.; Kibar, Melike; Atasever, Ayhan; Atalay, Özen; Beyaz, Latife

doi:10.1136/vr.160.14.486

Cited by 16 publications

(19 citation statements)

References 5 publications

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“…The anti-inflammatory effect of Theranekron could be attributed to its capability of inhibiting inflammation pathway and consequently enhanced tissue repair [12]. In healing process, inflammation is an inevitable phenomenon for mediator formation which in turn triggers reconstruction process [7,9,10,12]. Chronic inflammation may cause cell deterioration due to stabilized PMNs which function as supportive against microorganisms.…”

Section: Discussionmentioning

confidence: 99%

“…Reports indicate that it is helpful to bovine wound healing on day 14, leading to reduced inflammation and epithelialization [7,8]. Moreover, the extract reportedly reduces a wide range of infections [9,10]. Tarantula cubensis come from mygalomorph order/genus and is referred to as brown, hairy spider or mygalocubensis [11].…”

mentioning

confidence: 99%

“…The basic composition of the extract is prepared from the whole spider, with arachnid as its main elementIn doing so, the whole spider is initially crushed and an alcoholic extract with trade name Theranekron is produced [11]. investigated the effects of lavamisole and theranekron on skin papilloma and concluded that the former was more effective [10]. Gultiken, Vural, 2007 demonstrated that Theranekron was effective against breast benign tumors in dogs [5].…”

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confidence: 99%

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The effect of thranekron and autograft bone on bone defect healing in rabbit model

Sharifi

Bigham-Sadegh

Oryan

et al. 2020

Preprint

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Nowadays, bone grafting is used in both human and veterinary orthopedics to stimulate fracture healing, accelerate arthrodesis, and to restore bone defects. In such procedures, orthopedic surgeons are searching to favorable substitute for autograft bone. The present study seeks to investigate the use of Theranekron in bone defect healing process. 20 native rabbits (male rabbits weighing approximately 2 kg and aged 1.5-2 years) were divided into 4 groups of five, and bone fragments were removed from their radius bones. In the first group, Theranekron 1mg/kg was injected into bone defect. Normal saline was injected into the same site of the five rabbits in the second group (saline treated controls). As for the third group (the untreated controls), nothing was injected. In the fourth group (autograft group), the removed bone was put in place and muscle and skin were sutured. Post op lateral x-rays were prepared on days 14, 28, 42, and 56. Bone biopsy for histopathological study was performed after 8 weeks. Radiographs and samples were analyzed statistically in terms of union, osteogenesis activity, and bone Remodeling. Results: Radiological evaluation showed that autograft group was significantly superior to both untreated and saline treated controls (p=0.02, p=0.04, respectively). Also, Theranekron group proved better than untreated controls (p=0.04). Histopathological evaluation showed terabecular bone and bone marrow formations in Theranekron and also autograft groups. In the untreated and saline treated controls, most part of defect was filled with fibrous tissue. Conclusion: Theranekron treated group showed almost similarly to autograft counterpart, but better than normal saline and untreated controls. Keywords: Thranekron, Bone repair, Autograft, Rabbits

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The effect of thranekron and autograft bone on bone defect healing in rabbit model

Sharifi

Bigham-Sadegh

Oryan

et al. 2020

Preprint

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“…Theranekron is an alcohol extract of the Tarantula cubensis extract which is derived from the spider Tarantula cubensis (21). Limited studies have shown its beneficial effects in the treatment of bovine cutaneous papillomatosis, canine mammary adenocarcinomas, as well as in traumatic tendon injuries in rats, and in many inflammatory lesions, and wound healing processes (1,6,7,17). Although the mechanisms associated with its beneficial effect have not been fully elucidated, some research has indicated that theranekron may have an anti-inflammatory and inhibitory effect on catabolic enzymes (8).…”

Section: Original Investigationmentioning

confidence: 99%

Effect of tarantula cubensis extract (theranekron) on peripheral nerve healing in an experimental sciatic nerve injury model in rats

Kızılay¹,

Aktaş²,

Çetin³

et al. 2019

Turkish Neurosurgery

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AIM: To investigate the effects of systemic application of Theranekron on peripheral nerve healing after compression type peripheral nerve injury. MATERIAL and METHODS: Twenty-one female Wistar albino rats were randomly divided into 3 groups (n=7): Control (C), injury (I), and Theranekron (T). The right sciatic nerves of rats in the I and T groups were compressed via an aneurysm clip for 5 minutes and 0.3 ml Theranekron D6 was applied via subcutaneous administration once a week in the T group for a total period of four weeks. Nerve conduction velocity and proximal and distal latency of the rats were measured at the end of day 30. The right sciatic nerves of the rats were then removed and myelin damage grading, axon counting, fibrosis assessment, caspase-3, and NF-kB immunochemical staining were performed. The data were analysed statistically and a p value of less than 0.05 was considered to be significant. RESULTS: Axonal degeneration, vacuolization and myelin destruction were found to be markedly greater in group T. Fibrosis and caspase-3 immunoreactivity were less intense in group T. There was a statistically significant difference in the electrophysiological results of groups I and T. However, there were no statistically significant differences in axon number and NF-kB immunochemical evaluation of groups I and T. CONCLUSION: The findings of this study show that Theranekron decreases axonal and myelin damage after sciatic nerve injury and that this neuroprotective effect of Theranekron can be attributed to its anti-inflammatory effect on pro-inflammatory cytokine levels.

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“…Reports indicate that it is helpful to bovine wound healing on day 14, leading to reduced inflammation and epithelialization [2,19]. Moreover, the extract reportedly reduces a wide range of infections [5,12]. Tarantula cubensis come from mygalomorph order/genus and is referred to as brown, hairy spider or mygalocubensis [17].…”

Section: Introductionmentioning

confidence: 99%

The effect of thranekron and autograft bone on bone defect healing in rabbit model

Sharifi

Bigham-Sadegh

Oryan

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Nowadays, bone grafting is used in both human and veterinary orthopedics to stimulate fracture healing, accelerate joint union, and to restore bone defects. In such procedures, orthopedic surgeons are searching to favorable substitute for autograft bone. The present study seeks to investigate the use of this extract in bone defect healing process. 20 native rabbits were divided into 4 groups of five, and bone fragments were removed from their radius bones. In the first group, Theranekron 1mg/kg was injected into bone defect. Normal saline was injected into the same site of the five rabbits in the second group (saline treated controls). As for the third group (the untreated controls), nothing was injected. In the fourth group (autograft group), the removed bone was put in place and muscle and skin were sutured. Post op lateral x-rays were prepared on days 14, 28, 42, and 56. Bone biopsy for histopathological study was performed after 8 weeks. Radiographs and samples were analyzed statistically in terms of union, osteogenesis activity, and bone Remodeling.Results Radiological evaluation showed that autograft group was significantly superior to both untreated and saline treated controls (p=0.02, p=0.04, respectively). Also, Theranekron group proved better than untreated controls (p=0.04). Histopathological evaluation showed terabecular bone and bone marrow formations in Theranekron and also autograft groups. In the untreated and saline treated controls, most part of defect was filled with fibrous tissue.Conclusion Theranekron treated group showed almost similarly to autograft counterpart, but better than normal saline and untreated controls.

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Efficacy of levamisole and Tarantula cubensis venom for the treatment of bovine cutaneous papillomatosis

Cited by 16 publications

References 5 publications

The effect of thranekron and autograft bone on bone defect healing in rabbit model

The effect of thranekron and autograft bone on bone defect healing in rabbit model

Effect of tarantula cubensis extract (theranekron) on peripheral nerve healing in an experimental sciatic nerve injury model in rats

The effect of thranekron and autograft bone on bone defect healing in rabbit model

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