Efficacy of lisinopril in migraine prophylaxis – an open label study

Abstract

The ACE-inhibitor lisinopril has previously been shown to be effective in migraine prophylaxis at a daily dose of 20 mg. To test the effect of a low dose of lisinopril (5 mg daily) in migraine prevention, we performed an open label study in 21 migraineurs. The primary outcome measure was frequency of migraine attacks. Secondary efficacy measures were migraine hours, intake of acute migraine drugs, pain intensity and responder rate. Compared with baseline conditions, the attack frequency of migraine attacks was significantly reduced (P < 0.0005). The number of acute migraine drugs dropped significantly (P = 0.002). Three patients dropped out because of intolerable cough. Our study suggests that even low doses of lisinopril may be effective in migraine treatment. However, its use may be limited by intolerable side-effects.

Neuropathic pain-attenuating potential of aliskiren in chronic constriction injury model in rats

“…Various clinical studies have shown that ACE inhibitors, including enalpril and lisinopril, and angiotensin AT1 receptor blockers, including telmisartan, are effective in preventing the attacks of migraine. [26][27][28][29] The studies have shown the critical role of the renin-angiotensin system in the development of pancreatic neuropathy in experimental acute/chronic pancreatitis models as well in clinical pancreatitis. 8,30,31 In our previous study, telmisartan was reported to attenuate neuropathic pain behavior in the CCI model.…”

Hypertension and Migraine in the Northern Manhattan Study

“…Angiotensin I-converting enzyme is thought to be involved in blood pressure control and vascular tension; both angiotensin converting enzyme inhibitors and angiotension II receptor blockers have shown efficacy for migraine prevention. 17,18 The possible association between migraine with aura and elevated angiotensin-converting enzyme levels due Hypertension and Migraine -Gardener et al continued control of hypertension.…”

Renin–angiotensin system in pain: Existing in a double life?

“…38 Clinical studies have shown the important role of RAS in migraine pathophysiology 39 and, thus, AT 1 receptor blockers and ACE inhibitors have potential in the prophylactic management of migraine. ACE inhibitors (including enalapril and lisinopril) and angiotensin AT 1 receptor blockers (including telmisartan) are shown to be effective in preventing attacks of migraine [40][41][42][43][44] ( Figure 1). …”