Efficacy of live Chlamydophila abortus vaccine 1B in protecting mice placentas and foetuses against strains of Chlamydophila pecorum isolated from cases of abortion

Chlamydiaceae and chlamydial infections in sheep or goats

“…Occasional cases of abortions caused by C. pecorum have also been reported Rekiki et al, 2004). However, intravenous or intradermal inoculation of pregnant ewes with the organism did not induce the same abortion rate as C. abortus (Rodolakis and Souriau, 1989;Philips and Clarkson, 1998).…”

“…This attenuated vaccine (Cevac ® Chlamydia, Ovilis ® Enzovax) is effective in preventing abortion by all tested field strains Chalmers et al, 1997;Berri et al, 2004;Bouakane et al, 2005). This strain can also be administered simultaneously with the Brucella Rev1 vaccine and/or the Salmonella Rv6 vaccine (Souriau et al, 1988), a Toxoplasma vaccine (Chalmers et al, 1997) or a Coxiella burnetii vaccine (Rekiki et al, 2004), if the vaccines are simply injected at different sites of the animals. One vaccination is sufficient to protect for longer than three years; hence, in outbreaks of chlamydial abortions, initially, all the flock must be vaccinated before mating, followed by vaccination of only replacement animals in the following years.…”

Evaluation of the relationship between Chlamydia pecorum sequence types and disease using a species-specific multi-locus sequence typing scheme (MLST)

“…2010). Although rare, C. pecorum has also been associated with abortions in sheep as well (Rekiki et al, 2004). Regardless of the health status of studied animals, C. pecorum is also readily found in the gastrointestinal tract and subsequently shed in faeces (Clarkson and Philips, 1997;St George, 1971).…”

“…Interestingly, an outcome of these molecular studies was a potential revelation that certain C. pecorum strains may be associated with disease outcome (Sait et al, 2014;Yousef Mohamad et al, 2008), an observation that would appear to be reinforced by (a) a limited subset of experimental infection studies that showed the presence of potentially ''pathogenic'' and ''non-pathogenic'' strains of this species (Rekiki et al, 2004;Rodolakis et al, 1989); and (b) evidence that certain C. pecorum-infected populations of koalas and livestock appear unaffected by their infection while other populations develop severe disease (Kaltenboeck et al, 2005;Wan et al, 2011).…”

Chlamydia pecorum

“…10 Chlamydia pecorum is commonly detected in the digestive and genital tracts of healthy ruminants; however, it has also been associated with reproductive and systemic disorders in sheep, goats, buffalo, and cattle. 3,10,11,19,21,33 Although the involvement of C. pecorum in small ruminant abortion cases has been previously recognized, 4,[28][29][30] the abortigenic and zoonotic impacts of C. pecorum are still unknown, 4 and there are no reports, to our knowledge, describing fetal lesions caused by this agent in ruminants. In the current work, we describe placental and fetal lesions caused by C. pecorum in a case of sporadic abortion in a goat.…”