Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone

Şener, Mesut; Yilmazer, Cüneyt; Yılmaz, İsmail; Bozdogan, Nesrin; Özer, Cem; Dönmez, Aslı; Arslan, G.

doi:10.1016/j.jclinane.2007.09.009

Cited by 63 publications

(38 citation statements)

References 23 publications

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“…O adequado controle da dor pós-operatória constitui um desafio entre as especialidades cirúrgicas, a despeito dos recentes avanços das técnicas de analgesia e dos analgésicos 2 . Após a cirurgia de terceiros molares, a dor afeta praticamente todos os pacientes, atingindo intensidade máxima após 6 a 8 horas, e regredindo acentuadamente após as primeiras 24 horas 3 , sendo a medicação analgésica pós-operatória requerida pelos pacientes.…”

Section: Introductionunclassified

Dipirona versus paracetamol no controle da dor pós-operatória

Queiroz

Santos

Esteves

et al. 2013

Rev. odontol. UNESP

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ResumoIntrodução: A dor é definida como uma experiência desagradável, sendo o controle da dor pós-operatória um grande desafio na área da saúde. Objetivo: Comparar a eficácia da dipirona e do paracetamol no controle da dor pós-operatória após exodontia de terceiros molares inclusos. Material e método: Foram selecionados 30 pacientes da Disciplina de Cirurgia da Faculdade de Odontologia de Araçatuba -UNESP, que necessitavam extrair os terceiros molares inclusos. Desses, 15 receberam dipirona (Grupo I) e outros 15 receberam paracetamol (Grupo II) no pós-operatório. Todos os pacientes foram tratados, no pré-operatório, uma hora antes do procedimento cirúrgico, com dexametasona 4 mg e amoxicilina 1 grama. A intensidade da dor foi avaliada pelos pacientes por meio de escala visual analógica, em um período pós-operatório de 48 horas, em intervalos de 6 horas. Os critérios de exclusão foram: presença de desordens sistêmicas, hipersensibilidade medicamentosa, gestação, lactação e contraindicações locais. Os escores obtidos foram submetidos ao teste de Mann-Whitney (α = 0,05) para comparação das intensidades de dor em intervalos de 6 horas, nas 24 horas iniciais, nas 24 horas finais e no período total de 48 horas. Resultado: Não houve diferença estatística entre os analgésicos estudados nos intervalos de 6 horas; entretanto, nas 24 horas finais e nas 48 horas totais de observação, o Grupo I apresentou valores médios menores, estatisticamente significantes, quando comparado ao Grupo II. Conclusão: A eficácia analgésica da dipirona foi superior à do paracetamol.Descritores: Analgesia; terceiro molar; acetaminofen; dipirona. AbstractIntroduction: The pain is defined as an unpleasant experience, and control of postoperative pain a great challenge in healthcare. Objective: To compare the efficacy of Dipyrone and acetaminophen in postoperative pain after third molar surgery. Material and method: Thirty patients of the Discipline of Surgery of School of Dentistry of Araçatuba -UNESP, that needed to extract their third included molars, were selected. Among these, 15 received Dipyrone (group I) and the other received acetaminophen (group II) in the postoperative. All patients were treated pre-operatively with dexamethasone 4 mg and amoxycillin 1 g, one hour before surgery. Pain intensity was evaluated by a visual analogue scale by forty eight hours postoperative period and in intervals of six hours. The exclusion criteria were: presence of systemic disorders, drugs hypersensitivity, pregnant, lactic and local contraindications. The scores obtained were submitted to the Mann-Whitney test (p < 0,05) for comparison of the pain intensity in the 6 hours intervals, in the initial 24 hours, in the last 24 hours and in the total period of 48 hours. Result: There was no statistical difference among the analgesics in the 6 hours intervals, however, in the last 24 hours and in the total period of 48 hours, the group I presented smaller medium values, significant statistically, when compared to group II. Conclusion: The analgesic efficacy of...

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Section: Introductionunclassified

Dipirona versus paracetamol no controle da dor pós-operatória

Queiroz

Santos

Esteves

et al. 2013

Rev. odontol. UNESP

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“…Most studies have shown these drugs to be as effective as opioids. [6][7][8][9] There are many NSAIDs available; the main differences amongst them are the incidence and type of side-effects, predominantly gastric irritation and ulceration. Lornoxicam is a strong analgesic and anti-inflammatory NSAID with balanced COX-l/COX-2 inhibition and excellent tolerability.…”

Section: Discussionmentioning

confidence: 99%

Lornoxicam versus diclofenac sodium in acute renal colic: a prospective randomized trial

Godara

Srivastava

Vashist

et al. 2013

Int J Basic Clin Pharmacol

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Background: Acute renal colic is excruciatingly painful event, opioid analgesics and nonsteroidal anti-inflammatory drugs remain the mainstay of treatment for acute renal colic. This study compares diclofenac and lornoxicam in their efficacy to relieve pain of renal origin. Methods: Prospective, randomized, double blind clinical study including eighty patients with renal pain admitted in emergency department of a tertiary care teaching hospital. Parameters were observed at baseline and after 15, 30, 60, 180 minutes and 5hrs of drug treatment. The efficacy of the drug was measured by observing: Pain score, onset & duration of action, rescue drug use, global patient and physician impression. Results: Both drugs are effective in relieving pain of renal origin (p<0.05) and maintaining it over time as well. When decrease in value of pain score compared between two groups at various interval there was statistically significant (p<0.05) decrease in pain score only at 15 minutes in lornoxicam group showing this slightly more effective in early phase compared to diclofenac. In either group there is no statistically significant difference regarding onset of action, duration of action and side effect profile. Conclusions: Both the drugs are equally effective and safe in renal colicky pain with added advantage of lornoxicam being more effective in early period. [Int J Basic Clin Pharmacol 2013; 2(2.000): 193-198

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“…Septoplasty operations, which are considered as day care operations, are characterized with mild to moderate facial pain in the postoperative period. In this period nonsteroid antiinflammatory drugs (NSAID), paracetamol is often used [7]. Paracetamol usually provides inadequate analgesia and the side effects of agents like NSAIDs and opioids decrease patient satisfaction [8].…”

Section: Discussionmentioning

confidence: 99%

“…All the patients were given Patient controlled analgesia (PCA) with 4 mg/ml concentration, 10 mg/h infusion, 20 mg bolus, 15 min lock-out time. Total opioid consumption was calculated by multiplying the number of boluses with the amount of opioid in each bolus in milligrams at the end of 24 h. Following extubation, patients were transferred to the recovery room and mean arterial pressure, VAS score, PCA demand and delivery values, side effects (hypotension, bradycardia, nausea, vomiting, pruritus) and additional analgesic consumption were recorded at 20, 40, 60 min and 2nd, 4th, 6th, 12th and 24th hours by an anaesthesiologist who was blinded to the groups, parallel to previous studies [4][5][6][7]. The patients were asked to rate their satisfaction according to Likert scale (1: Completely comfortable, 2: Very comfortable, 3: Slight discomfort, 4: Painful, 5: Very painful) at the end of 24 h. The patients were also evaluated for a burning sensation and bleeding in the nose.…”

Section: Methodsmentioning

confidence: 99%

“…Sample size calculation was based on an expected difference of 13 mm in the VAS measurement of pain between group means, based on a reported value of minimal clinically important differences in acute pain, on a standard deviation of 15, obtained from previous studies [7] with Power = 0.90 and a = 0.05. A sample size of 30 patients per group was obtained.…”

Section: Methodsmentioning

confidence: 99%

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The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

Ekmekçi

Beriat

Bengisun

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Tramadol is a centrally acting opioid which is effective for moderate-severe pain and is being used for various acute and chronic pain scenarios. The primary endpoint of this controlled, randomized double blind study was to evaluate the effect of submucosal tramadol on VAS scores after septoplasty operations and secondary endpoint was to investigate the effects on total opioid and additional analgesic consumption and patient satisfaction. 60 patients scheduled for septoplasty under general anaesthesia were enrolled. In Group T, at the end of surgery following hemostasis, 2 mg/kg tramadol was applied as submucosal infiltration to both surgical sites, 2 ml (total 4 ml), by the surgeon. In Group P, at the end of surgery following hemostasis, 2 ml isotonic solution (total 4 ml) was applied as submucosal infiltration to both surgical sites by the surgeon. Total opioid consumption, VAS scores, patient satisfaction was evaluated at the end of 24 h VAS values were higher in Group P on the first and second postoperative hours. Patient controlled analgesia demand and delivery values were higher in Group P on the postoperative 1, 2, 4, 6, 12 and 24th hours. Patient satisfaction was higher and opioid consumption was lower in Group T compared to Group P. There was no difference in additional analgesic consumption between two groups. The results show that patients receiving tramadol had lower VAS scores compared with the placebo groups postoperatively.

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Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone

Cited by 63 publications

References 23 publications

Dipirona versus paracetamol no controle da dor pós-operatória

Dipirona versus paracetamol no controle da dor pós-operatória

Lornoxicam versus diclofenac sodium in acute renal colic: a prospective randomized trial

The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

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