Efficacy of low dose intravenous immunoglobulins for post-splenectomy treatment of autoimmune haemolytic anaemia in a patient with hereditary spherocytosis

Abstract

Summary Idiopathic autoimmune haemolytic anaemia developed in a patient with hereditary spherocytosis. The behaviour of some osmotic fragility tests throughout the illness and the efficacy of intravenous immunoglobulins in controlling autoimmune haemolysis which recurred post splenectomy are discussed

Intravenous immune globulins: an update for clinicians

“…204 Hematologic immunemediated cellular disorders: autoimmune hemolytic anemia, autoimmune neutropenia, fetal-neonatal alloimmune thrombocytopenia; HLA-alloimmune thrombocytopenia Isolated case reports continue to appear attesting to a possible role for IVIG in refractory autoimmune hemolytic anemia, however, it is difficult to sort out effects of other simultaneously administered medications and procedures. 205,206 In a test of IVIG in autoimmune neutropenia in infancy, 10 of 20 treated patients responded transiently. 207 Maternally administered IVIG (1 g/kg/week) appears to prevent intracranial hemorrhage and raises platelet counts in the majority of fetuses with alloimmune thrombocytopenia.…”