Efficacy of Low Temperature Plasma against SCaBER Cancer Cells

Plasma Processes & Polymers

2014

Self Cite

127

Section: Mechanisms Of Action Of Ltp and Safety Issuesmentioning

confidence: 99%

From Killing Bacteria to Destroying Cancer Cells: 20 Years of Plasma Medicine

Plasma Processes & Polymers

2014

Self Cite

127

“…1,2 Several investigators used PAM successfully and showed that it has killing and anti-proliferative effects against various cancers including ovarian cancer, gastric cancer, glioblastoma, and breast cancer. [1][2][3][4][5] Therefore, using PAM can be a practical alternative for treating cancerous lesions since PAM has been shown to remain effective after a relatively long time of storage (hours to days depending on storage temperature).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of a plasma activated medium on cancer cells

Mohades

Sears³

et al. 2015

Physics of Plasmas

124

The interaction of low temperature plasma with liquids is a relevant topic of study to the field of plasma medicine. This is because cells and tissues are normally surrounded or covered by biological fluids. Therefore, the chemistry induced by the plasma in the aqueous state becomes crucial and usually dictates the biological outcomes. This process became even more important after the discovery that plasma activated media can be useful in killing various cancer cell lines. Here, we report on the measurements of concentrations of hydrogen peroxide, a species known to have strong biological effects, produced by application of plasma to a minimum essential culture medium. The activated medium is then used to treat SCaBER cancer cells. Results indicate that the plasma activated medium can kill the cancer cells in a dose dependent manner, retain its killing effect for several hours, and is as effective as apoptosis inducing drugs. V C 2015 AIP Publishing LLC.

“…After LTP exposure and proper incubation process (37 ℃ under 5% CO2 atmosphere), Trypan-blue exclusion assay was used to count the number of live and dead cells. For details of the experimental protocol please refer to [40]. The counts immediately after LTP treatment (at 0 h) revealed no dead cells, which suggested there were no immediate physical …”

Section: Two Biomedical Applications Of Ltpmentioning

confidence: 99%

“…This is an indication that plasma agents, such as reactive species and electric fields, interact with the cells and induce reactions and/or trigger biochemical pathways that ultimately result in the death of the cancer cells hours later. [40]. Figure 7 shows the selective effect of LTP when it comes to destroying cancer cells versus healthy cells in vitro.…”

Section: Two Biomedical Applications Of Ltpmentioning

confidence: 99%

Plasma Medicine: A Brief Introduction

2018

Plasma

Self Cite

179

122

This mini review is to introduce the readers of Plasma to the field of plasma medicine. This is a multidisciplinary field of research at the intersection of physics, engineering, biology and medicine. Plasma medicine is only about two decades old, but the research community active in this emerging field has grown tremendously in the last few years. Today, research is being conducted on a number of applications including wound healing and cancer treatment. Although a lot of knowledge has been created and our understanding of the fundamental mechanisms that play important roles in the interaction between low temperature plasma and biological cells and tissues has greatly expanded, much remains to be done to get a thorough and detailed picture of all the physical and biochemical processes that enter into play.