Efficacy of lycopene against fluoride toxicity in rats

Mansour, Heba H.; Tawfik, Sameh

doi:10.3109/13880209.2011.618994

Cited by 25 publications

(10 citation statements)

References 26 publications

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“…Thereafter, the twenty‐one male SD rats were randomly assigned as four groups, including normal group (n = 3), model group (n = 6), low‐dose lycopene group (n = 6), and high‐dose group (n = 6) for non‐treatment, intragastric corn oil, intragastric lycopene at 10 mg/(kg/d), and intragastric lycopene at 20 mg/(kg/d) treatments, respectively. Specifically, LYC was dissolved in corn oil in each group …”

Section: Methodsmentioning

confidence: 99%

Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF‐κB, MAPKs, and Nrf2 signaling pathways in rats

et al. 2020

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Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is identified as a urinary andrological diseases that afflict men due to various discomforts. It is urgent and meaningful to develop the novel and effective treatments as a result of the unclear etiology and dismal therapeutic effect of CP/CPPS. Lycopene exerts a crucial role in numerous chronic inflammatory diseases owing to its potent antioxidant capacity.Objective: This study aimed to observe the effect of lycopene on CP/CPPS and to explore the underlying mechanisms. Materials and Methods:A CP/CPPS model with complete Freund's adjuvant was established in this study. Afterward, intragastric lycopene or corn oil was administered daily for 4 consecutive weeks. Finally, the cardiac blood and prostate tissue samples were collected from rats to carry out related evaluation and testing. Results:It was found in this study that lycopene alleviated changes in prostate histopathology compared with those in the complete Freund's adjuvant-induced CP/ CPPS model rats without lycopene treatment. Furthermore, lycopene was suggested to reduce the levels of chemokines MCP1 and MIP-1α, down-regulate the expression levels of cytokines (such as TNFα, IL-1β, IL-2, and IL-6), and up-regulate those of CAT, GSH-PX, and T-SOD, decrease that of malondialdehyde. Moreover, it also inhibited the phosphorylation of MAPKs, NF-κB, and enhanced phosphorylation of the Nrf2 in the CP/CPPS rat model. Discussion and Conclusions:The findings in this study suggest that lycopene exerts potent anti-CP/CPPS effects through alleviating inflammatory response and oxidative stress, which is probably attributed to the interaction of NF-κB, MAPKs, and Nrf2 signaling pathways in rats. As a natural antioxidant, lycopene may serve as a promising pharmaceutical preparation for treating CP/CPPS.

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Section: Methodsmentioning

confidence: 99%

Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF‐κB, MAPKs, and Nrf2 signaling pathways in rats

et al. 2020

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“…Li et al (2017) reported that lycopene significantly affected NaF-induced ameloblast and tooth fluorosis by reducing oxidative stress and the caspase pathway [9]. Mansour and Tawfik (2012) demonstrated that lycopene administration to NaF-administered rats could reduce the toxic effects of fluoride that characterized the free radical and strong antioxidant activities of the fluoride [10]. In the present study, it was determined that low concentrations of lycopene (1 μM, 2 μM, 5 μM and 10μM) reduced the toxic effect of NaF, while in the high concentration lycopene treated groups, it increased NaF toxicity via its synergistic effect.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Lycopene Application on Sodium Fluoride (NaF) Applied Renal Cell Line

Çetin

2017

International Journal of Secondary Metabolite

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The present study was planned to investigate the potential protective properties of lycopene, an antioxidant carotenoid, on NaF applied renal cell line. NRK-52E cells were cultured under standard in vitro conditions with regular passages. 10.000 NRK-52E cells were planted in each culture platelet. Cells were incubated for 24 hours at 37°C in an incubator with CO 2 . After the incubation, the medium formed on the cells was removed and the prepared NaF and lycopene solutions were added. At least 4 wells were used for each dose. Culture vessels were incubated at 37°C in a CO 2 incubator for 6, 12, and 24 hours for transformation of non-soluble formazan crystals by MTT stain and the MTT assay was conducted. In conclusion, it was found that low lycopene concentrations reduced the toxic effect of NaF by 10-20%, while lycopene increased the toxic effect of NaF synergistically in the high concentration lycopene treated groups. Thus, it was concluded that administration of lycopene on NaF applied renal cell line exhibited different effects based on concentration and duration.

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“…activity of SOD in  activity of catalase in liver [120] Male albino rats exposed at 10, 50 and 100 mg/L in drinking water for 10 weeks Generation ROS in blood, liver, kidney, and brain GSH/GSSG ratio in liver, kidney, and brain [121] Female Albino mice exposed 5 mg/kg body weight/day, orally for 30 days Activities of SOD, catalase, and GSH-Px, level of GSH, total, dehydro and reduced ascorbic acid, lipid peroxidation in ovary [122] Male Balb/c mice exposed at 200 mg/L, in drinking water for 7 days Activities of SOD, GSH-Px, and catalase, lipid peroxidation, in erythrocytes, and liver [123] Female Wistar rats exposed at 150 mg/L in drinking water for 28 days Level of GSH, activities of SOD, GPx, catalase and, glutathione reductase, lipid peroxidation in brain [101] Wistar albino pups placentally and lactationally exposed from mother rats at Table 8. 03 Adsorption Waste tea ash [131] 04 Adsorption Neem charcoal [132] 05 Adsorption Calcined bauxite, gypsum, magnesite and their composite fi lter [133] 06 Adsorption Activated alumina [134][135][136] 07 Adsorption Bone char [67,137] 08 Adsorption Activated carbon [138,119] [166]…”

Section: Amelioration Of Fl Uoride Toxicitymentioning

confidence: 99%

Fluoride Sources, Toxicity and Its Amelioration: A Review

Bharti¹,

Giri²,

Kumar³

2018

Ann Environ Sci Toxicol

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In recent scenario, fl uorosis is now going to be a severe problem throughout the globe due to toxic effects of fl uoride (F) on both plants and animals. F presents in the halogenated group of the periodic table and has the characteristics of electronegativity. Natural geological sources and increased industrialization have contributed greatly to the increasing incidence of fl uoride-induced human and animal health issues. In animals and human beings, it exerts adverse effects mainly through the attenuation of antioxidant defense mechanism and chelation of enzymatic cofactors. Thereafter, it causes metabolic disorders through interacting with various cellular processes such as gene expression, cell cycle, metabolism, ion transport, hormonal secretion, endocytosis, apoptosis, necrosis, and oxidative stress. These effects lead to dental mottling, skeletal dysfunctions including crippling deformities, osteoporosis, and other vital organs dysfunction. It was found that, water is the main source of fl uoride intake to plants and animals, which further may go into food chain of human beings through consumption of high fl uoride content plant and animal origin food. Several preventive and control measures have been developed to ameliorate the fl uoride toxicity, like application of synthetic chemicals, plants bioactive molecules, and plant products like fruit pulp, seed mixture, and plant buckle products. Therefore, this article presents up-to-date information on the fl uoride sources, toxicity and different amelioration measures to reduce fl uoride level directly from water as well as application of different natural/synthetic products/molecules to ameliorate the toxic effects of fl uoride in in-vivo models.

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Efficacy of lycopene against fluoride toxicity in rats

Cited by 25 publications

References 26 publications

Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF‐κB, MAPKs, and Nrf2 signaling pathways in rats

Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF‐κB, MAPKs, and Nrf2 signaling pathways in rats

The Effects of Lycopene Application on Sodium Fluoride (NaF) Applied Renal Cell Line

Fluoride Sources, Toxicity and Its Amelioration: A Review

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