Efficacy of mangiferin on serum and heart tissue lipids in rats subjected to isoproterenol induced cardiotoxicity

Sukumaran, Prabhu; Devi, C. S. Shyamala

doi:10.1016/j.tox.2006.08.030

Cited by 44 publications

(21 citation statements)

References 17 publications

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“…We suggest that mangiferin may contribute to diminish Lipofundin-induced damage. Jagieta and Venkatesha demonstrated that mangiferin scavenges ROS and protects against ultraviolet irradiation-induced OS [27]. Also, Nair and Devi showed that mangiferin has hypolipidemic properties [28].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Mangifera indica L. Extract Against Lipofundininduced Oxidative Stress in Rats

Roche¹

2012

TOPHARMCJ

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Lipofundin is a lipid rich emulsion used in parenteral nutrition. It is known that Lipofundin induces an oxidative stress state characterized by an increase of lipid peroxidation and a dramatic depletion of antioxidants. The aim of the present study was to evaluate the effects of an aqueous extract of Mangifera indica L., on Lipofundin-induced oxidative stress. Male Sprague Dawley rats were treated orally with 200 mg/kg of Vimang®, followed by an intravenous dose of 2 mL/kg Lipofundin, daily, for 8 days. Selected oxidative stress biomarkers were then measured spectrophotometrically. The results showed that Vimang® produced significant (p<0.05) reduction of malondialdehyde, total hydroperoxides and advanced oxidation protein products, while the activities of superoxide dismutase and catalase were positively modulated. A significant (p<0.05) reduction of peroxidation potential and a preservation of glutathione and total antioxidant status was also observed. Our data demonstrated that Vimang® protects against Lipofundin-induced oxidative stress, which is an important finding that further reinforces the antioxidant properties of this natural product.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Mangifera indica L. Extract Against Lipofundininduced Oxidative Stress in Rats

Roche¹

2012

TOPHARMCJ

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“…Mangiferin has a significant role in the reduction of cholesterol, triglycerides, and free fatty acid (FFA) levels in both serum and heart, and can also enhance heart tissue phospholipid levels in isoproterenol-induced cardiotoxic rats [82]. Mangiferin preserved lysosomal integrity by decreasing the inflammatory process.…”

Section: Cardiovascular Protective Rolementioning

confidence: 99%

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

et al. 2017

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The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.

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“…Of the many well-known model's isoproterenol (ISO)-induced myocardial necrosis, this rat model has often been used to evaluate several cardiac dysfunctions. ISO causes stress in the myocardium and a severe increase in the levels of serum and myocardial lipids, and also increases the level of LDL cholesterol in the blood, which in turn leads to coronary heart disease [2]. A number of patho-physiogenic mechanisms have been outlined to explain the lesions produced by ISO in experiments.…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Efficacy of Taurine on Lipid-Metabolism of Isoproterenol-Induced Myocardial Infarction

Abdel-Reheim

2016

Int J Pharm Pharm Sci

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Objective: The present study aimed to evaluate the effect of pre-treatment with taurine on rats in which MI had been induced using isoproterenol (ISO).Methods: Rats were randomly allocated into three groups; the 1st group is the normal control (C) one, the 2nd is the isoproterenol cardiotoxic (ISO) one and the 3rd group is the taurine pretreated (T-ISO) one. Results:The activities of the cardiac biomarker enzymes, AST, LDH, CK and CK-MB were elevated in the ISO-treated group. The membrane-bound Na + -K + and Ca 2+ ATPase enzyme activities were decreased in the ISO-treated group. The lipid profile either in sera or cardiac tissues was increased in ISO-treated rats except for HDL-cholesterol and phospholipids. The cholesterol ester synthetase (CES) activity was elevated, while lecithin: Cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) activities were decreased in the myocardial infarcted rats. In addition, the high level of the troponins I and T was an indication of cardiac necrosis. Pre-treatment with Taurine, however, ameliorated all of these changes, in addition to its effect in improving the oxidation process, as measured by lipid peroxidation and the antioxidant enzymes, superoxide dismutase and peroxidase enzymes. Conclusion:Taurine showed amelioration effects on the changes in lipid profile, oxidative stress and myocardial infarction biomarkers and therefore, can be protected against cardiotoxicity.

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Efficacy of mangiferin on serum and heart tissue lipids in rats subjected to isoproterenol induced cardiotoxicity

Cited by 44 publications

References 17 publications

Protective Effects of Mangifera indica L. Extract Against Lipofundininduced Oxidative Stress in Rats

Protective Effects of Mangifera indica L. Extract Against Lipofundininduced Oxidative Stress in Rats

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

Cardioprotective Efficacy of Taurine on Lipid-Metabolism of Isoproterenol-Induced Myocardial Infarction

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