Efficacy of maropitant for treatment and prevention of emesis caused by intravenous infusion of cisplatin in dogs

Abstract

Results suggest that maropitant is safe and effective in the treatment and prevention of cisplatin-induced emesis in dogs.

Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone

“…It has been shown to be highly effective in preventing vomiting secondary to a broad spectrum of emetic stimuli including cisplatin, apomorphine, copper sulfate, motion sickness and a wide range of clinical causes of vomiting (Benchaoui et al. 2007; De La Puente‐Rendondo et al. 2007a,b; Vail et al.…”

Efficacy of orally administered maropitant citrate in preventing vomiting associated with hydromorphone administration in dogs

“…15,16 Vomiting may also be undesirable in certain clinical cases wherein increases in intraocular or intracranial pressure caused by vomiting may lead to increased patient morbidity. [23][24][25][26] Results of a previous study 9 in dogs indicate that maropitant citrate (1.0 mg/kg [0.45 mg/lb], SC) injected 1 hour prior to premedication with hydromorphone (0.1 mg/kg [0.045 mg/lb], IM) was effective in preventing vomiting and signs of nausea. It is used clinically to treat vomiting attributable to a wide range of clinical causes.…”

Efficacy of Maropitant in the Prevention of Delayed Vomiting Associated with Administration of Doxorubicin to Dogs

“…Maropitant proved effective in the prevention and treatment of acute vomiting events in dogs receiving cisplatin chemotherapy 7–9 . Current guidelines from the American Society of Clinical Oncologists in 2006, however, advocate the use of NK 1 receptor antagonists not only for acute emesis, but also delayed chemotherapy induced nausea and vomiting 10 …”