Efficacy of Medical Expulsive Treatment With Doxazosin in Pediatric Patients

Erturhan, Sakıp; Bayrak, Ömer; Sarıca, Kemal; Şeçkiner, İlker; Baturu, Muharrem; Şen, Haluk

doi:10.1016/j.urology.2012.11.031

Cited by 43 publications

(57 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the systematic review by Glina et al [7], there is no mention of side-effects analysis. When examining the prospective series individually, no adverse effects were reported, other than somnolence, nausea and vomiting experienced by one patient in the study conducted by Erturhan et al [10] and 3 patients experiencing mild nasal congestion in the study by Aldaqadossi et al [11]. No adverse reactions to tamsulosin were observed in the retrospective cohort by Tasian et al [12].…”

Section: Safety Of Met In Childrenmentioning

confidence: 92%

“…Similar results were reported in the study by Aldaqadossi et al [11], again in favour of tamsulosin for an equal follow-up period (7.7 vs. 18 days) (LE: 1b). Erturhan et al [10] studied prospectively doxazosin in distal ureteric stones and found expulsion rates of 70.8 vs. 28.5% in the control group of ibuprofen for a follow-up of 3 weeks (LE: 1b). Similar results were reported by Aydogdu et al [9] for equal follow-up periods (84 vs. 70%), although the authors concluded the contrary despite calculating statistical significance (LE: 1b).…”

Section: Efficacy Of Met In Childrenmentioning

confidence: 99%

See 1 more Smart Citation

The Evidence Paradox of the Effectiveness between the Paediatric and Adult Stone-Forming Population: A Narrative Review

Bourdoumis

Durner²,

Füllhase

et al. 2019

Urol Int

View full text Add to dashboard Cite

Aim/Objective: To identify trends in the evidence base regarding the effectiveness of using α-blockers in children versus adults and compare outcomes. Methods: A literature search up using the key words including urolithiasis/renal/ureteric stone in children/paediatric population, medical expulsive treatment (MET), α-blocker/alfuzosin/tamsulosin/doxazosin. Included were randomized or controlled clinical trials in paediatric stone formers (aged ≤18 years). Outcome measures for assessment included the overall stone expulsion rate, expulsion time, the number of pain episodes and adverse drug effects and/or reactions. Further comparison of efficacy levels using respective studies from the adult population was performed in order to identify trends, similarities and differences. Results: A total of 8,259 articles were identified. Full text evaluation was possible for 28 articles. Although the picture is clearer in the paediatric group, the lack of reproducible results in adults certainly poses serious questions about data collection, analysis and interpretation in each individual study. The apparent paradox is due to the methodological differences between studies. Conclusion: The effectiveness of α-blockers and other medication as MET needs to be studied in multi-institutional, double-blind, placebo-controlled studies that would aim to prove superiority to placebo in contemporary clinical situations, with realistic end points and standardized outcome measure determination.

show abstract

Section: Safety Of Met In Childrenmentioning

confidence: 92%

Section: Efficacy Of Met In Childrenmentioning

confidence: 99%

The Evidence Paradox of the Effectiveness between the Paediatric and Adult Stone-Forming Population: A Narrative Review

Bourdoumis

Durner²,

Füllhase

et al. 2019

Urol Int

View full text Add to dashboard Cite

show abstract

“…In addition to higher rates of stone passage, number of painful episodes, and need for analgesic decreased. [30] A total of 449 children were included in the last study. Treatment lasted for 6 weeks.…”

Section: Introductionmentioning

confidence: 99%

Medical expulsive treatment in pediatric urolithiasis

Atan

Balcı

2015

Turkish Journal of Urology

View full text Add to dashboard Cite

The frequency of stone disease in childhood ranges between 0.1-5 percent. Stone disease occurs as a result of enviromental, metabolic, anatomical, infectious and nutritional factors. Percutaneous nephrolitotomy, uretherorenoscopy, laparoscopic surgery, open surgery and extracorporeal shock wave lithothripsy are treatment alternatives for stone disease during childhood. However, these methods are not completely innocent. Some complications may occur after these procedures. These procedures are generally not cost-effective. Even invasive procedures have high success rates, so medical expulsive treatment modalities have become an alternative for a group of patients. Nonsteroidal anti-inflammatory drugs, antimuscarinic drugs, phospodiesterase type 5 inhibitors, steroids, calcium channel blockers and alpha blockers are treatment alterneatives used for this modality in the literature. The drug is chosen according to the location, size, and composition of the stone, recent technology, cost, surgeon's experience and surgeon's and the parents' preferences. In this review article the following topics will be discussed such as "Why medical expulsive treatment is needed during childhood? Which drug should be chosen for which stone type? How long should a treatment of urolithiasis last?

show abstract

“…Recent pilot study suggests the potential efficacy of doxazosin when rapidly titrated in reducing cocaine use (Shorter et al, 2013). Another recent study recommended use of doxazosin to render children stone free within a shorter period, which would inevitably diminish the number of colic attacks and the need for analgesic usage (Erturhan et al, 2013). Combined doxazosin and finasteride therapy improved LUTS and reduced the risk of overall clinical progression of BPH compared to each drug separately in men followed over 4 years (Wilt & MacDonald 2006).…”

Section: Introductionmentioning

confidence: 99%