Efficacy of Monolayer Preparations for Cervical Cytology

Increased Detection of Epithelial Cell Abnormalities by Liquid-Based Gynecologic Cytology Preparations

“…Nine studies were identified that compared the AutoCyte PREP (AutoCyte, Inc., Elon College, North Carolina, U.S.A.) with the conventional cervical cytologic smear. 4,11,12,21,24,28,32,39,41,45 Data were also analyzed from two PMA clinical trials for ThinPrep and one PMA clinical trial submission for AutoCyte PREP. Potential for increased detection of precancerous and neoplastic lesions was assessed from these studies by comparing epithelial cell abnormalities at the level of low grade squamous intraepithelial lesions (LSILs) or higher (LSIL +) detected by each of the liquid-based preparations and by the conventional smear.…”

CIN 2/3 and Cervical Cancer After an ASCUS Pap Smear

“…Other strategies suggested have been to improve the test or replace it. Other modes of testing to reach a definitive diagnosis might be a monolayer, which would presumably reduce the number of equivocal smears and a better "cell yield" and overall better diagnostics due to technically better smears 10,40 or automated screening, which increase sensitivity when few abnormal smears are present. 41 The consensus guidelines of the American Society for Colposcopy and Cervical Pathology 23 recommend HPV testing to identify women with oncogenic risk types [42][43][44][45] ; it could be used to distinguish patients with and without an underlying lesion.…”

Feasibility of Cytology-Based Cervical Cancer Screening in Rural Cameroon

“…The liquid-based Feasibility of Cervical Screening preparatory technique allows immediate fixation and removal of excess white cells, blood artefacts, debris and bacteria and therefore better visualization of cells. 4,[16][17][18] The conventional smears were processed and analyzed at Ad Lucem Hospital and the results communicated to the patient within 24 hours. The liquid-based samples were sent to Geneva, where they were prepared and analyzed at the Center of Cytology and Clinical Pathology.…”