Efficacy of Montelukast and Ranitidine as an Add on Therapy for Chronic Urticaria

Is montelukast effective for treating patients with chronic urticaria?

“…In 2018, a prospective, randomized, open-label study compared the efficacy of combined therapy of montelukast and cetirizine versus combined therapy with ranitidine and cetirizine in patients with chronic urticaria. 2 One hundred patients 18 to 60 years were enrolled; of whom, 93 completed the study (62 women and 31 men). Inclusion criteria consisted of patients who did not respond to two weeks of treatment with cetirizine, urticaria of greater than six weeks duration, no treatment with steroids and other immunosuppressant for urticaria or other diseases, and no urticaria associated with other skin disorders like eczema.…”