Efficacy of new beverage made of dates vinegar and garlic juice in improving serum lipid profile parameters and inflammatory biomarkers of mildly hyperlipidemic adults: A double-blinded, randomized, placebo-controlled study

Abstract

A beverage made from date vinegar and garlic juice was recently developed for use by people who wish to attain maximum quantities of both vinegar and polyphenols for their health and do not like to use vinegar and garlic directly in their daily diet. Fifty hyperlipidemic adults consumed two cups (500 mL) of either the new beverage or a placebo daily over a period of 7 weeks. Plasma lipids, inflammatory biomarkers, urea, creatinine, potassium, and β‐carotenoid concentrations were measured before and after each treatment. A recommended dose of 500 mL of the new beverage reduced total cholesterol (TC) (260.10 ± 17.9 to 198.90 ± 17.31 mg/dL) and C‐reactive protein (CRP) (8.04 ± 1.34 to 4.45 ± 1.42 mg/L) along with heart rate and mean blood pressure. These outcomes indicate that the new beverage improved the concentration of lipids and inflammatory biomarkers, and the new beverage is beneficial for people who are worried about hypertension. Practical applications Dietary therapy is the primary step in the treatment of hyperlipidemia. Dates, compared with different fruits, are a rich source of phenolic compounds. Researchers have claimed that extract of date fruit is effective in improving lipid profile parameters. Similarly, evidence from other studies has indicated that garlic can bring about the regulation of blood cholesterol along with the improvement of fibrinolytic activity and decrement of blood pressure. Thus, this study will provide a possible source of phenolic compounds and present a latent approach to the avoidance of hyperlipidemia and hypertension. This new beverage is suggested as a dietary supplement for the promotion of a healthy heart.

Effects of Daily Low-Dose Date Consumption on Glycemic Control, Lipid Profile, and Quality of Life in Adults with Pre- and Type 2 Diabetes: A Randomized Controlled Trial

“…A similar effect was reported during 13 weeks of dates supplementation in hamsters [14]. Another possible explanation could be that the increased concentrations of plasma carotenoids released during the digestion of dates competed with dietary lipids for assimilation and transport in lipoproteins, subsequently leading to lower cholesterol levels [27]. Contrary to our results, the study of Rock et al [28] found no statistically significant effect of date consumption in healthy human subjects on total cholesterol and HDL level.…”

Anti-Inflammatory and Cytotoxicity Effects of Cudrania tricuspidata Fruits Vinegar in a Co-Culture System with RAW264.7 Macrophages and 3T3-L1 Adipocytes

“…Vinegar has been found to possess inhibitory effects against immunoglobulin E (IgE) production, immune cell infiltration, Th1 or Th17 responses, and Toll-like receptor (TLR)4-induced inflammatory response [10][11][12]. Moreover, vinegar supplementation reduced the levels of interleukin-6 (IL-6), an inflammatory cytokine, and the biomarkers nitric oxide (NO) and TNF-α in a clinical study [13][14][15][16]. Recently, vinegars have been reported to reduce body fat and glucose levels, as well as exert anti-oxidant, anti-tumor, and anti-microbial effects [15][16][17][18][19].…”

Preliminary study to evaluate the phytochemicals and physiochemical properties in red and black date's vinegar

“…Dates contain fiber vital mineral (iron, selenium fluorine, and calcium) and vitamins (Vayalil, ). Results have shown that extracts from dates have exposed free radical scavenging activity, immunomodulatory, and antimutagenic activities, (Allaith, ; Khan, Sarwar, Wahab, & Haleem, ) and dates have cardioprotective, anti‐inflammatory, antiobesity, and antihypertensive effects (Ali, Ma, Ayim, & Wali, ; Ali, Ma, Rashid, et al, ). In the past, dates' vinegar did not receive the attention it deserves due to limited literature about the fruit.…”