Efficacy of new natural biomodification agents from Anacardiaceae extracts on dentin collagen cross-linking

Moreira, Marcelo Aldright; Souza, Nayara de Oliveira; Sousa, Raisa Santiago; Freitas, De; Lemos, Marcelo Victor Sidou; Paula, D M De; Maia, Francisco Jonas Nogueira; Lomonaco, Diego; Mazzetto, Selma Elaine; Feitosa, Victor Pinheiro

doi:10.1016/j.dental.2017.07.003

Cited by 44 publications

(42 citation statements)

References 34 publications

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“…3 To overcome these limitations which prevent stable dentin adhesion, there has been an intense search for protocols and techniques that favor bonding with the root dentin. 4,5,6,7,8 The difficulty in achieving a stable hybrid layer with dentin tissue is related to the hydrophilic nature and organic structure of the sealer, 9,10 which can interfere with the sealer-dentin interaction. 11 In fact, incomplete infiltration of resinous monomers into collagen fibers within the hybrid layer favors hydrolysis and degradation of collagen by metalloproteinase (MMP), thus reducing the bonding longevity.…”

Section: Introductionmentioning

confidence: 99%

Chlorhexidine and proanthocyanidin enhance the long-term bond strength of resin-based endodontic sealer

et al. 2018

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The aim of this study was to evaluate the effects of proanthocyanidin (PA) and chlorhexidine (CHX) on the bond strength (BS), failure pattern, and resin-dentin interface morphology of the endodontic sealers EndoREZ and AH Plus after 24 h and 6 months of water storage. A total of 120 prepared bovine roots were divided into six groups: AH Plus, CHX+AH Plus, PA+AH Plus, EndoREZ, CHX+EndoREZ, and PA+EndoREZ. Dentin was treated for 1 or 5 min with 2% CHX or 15% PA, respectively. Roots were filled and stored in water for 24 h or 6 months (n = 10). Root slices were subjected to push-out test and scanning electron microscopy (SEM). Data were compared using two-way ANOVA and student's t-test (α = 5%). BS decreased over time for AH Plus and untreated EndoREZ (p < 0.05). At 24 h, AH Plus had higher BS than EndoREZ (p < 0.001), with no differences among treatments for both sealers (p > 0.05). At 6 months, EndoREZ had higher BS values for CHX and PA than control (p < 0.05). AH Plus had higher BS than EndoREZ (p < 0.001), while with CHX or PA, similar BS was observed in both sealers (p > 0.05). Cohesive and mixed failures were observed in all groups. SEM revealed sealer tags in the root dentin. In conclusion, BS decreased with time and AH Plus had higher BS than EndoREZ in untreated dentin; however, CHX or PA enhanced long-term BS of EndoREZ. Overall, dentin treatment affected failure pattern and resin-dentin interface morphology, particularly for EndoREZ.

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Section: Introductionmentioning

confidence: 99%

Chlorhexidine and proanthocyanidin enhance the long-term bond strength of resin-based endodontic sealer

et al. 2018

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“…Além do aumento do ME demonstrado no presente estudo, observa-se uma característica favorável para sua implementação na prática clínica, que é a influência na coloração, que as PAs pigmentam fortemente o substrato 17 , o que não é observado nos grupos usando TA, o que viabiliza o seu uso na odontologia estética, tornando-o bastante promissora a sua aplicabilidade.…”

Section: Discussionunclassified

Ácido tânico como agente biomodificador de dentina

et al. 2019

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Introdução: a utilização de diferentes polifenóis no aumento das propriedades mecânicas do colágeno dentinário tem sido bastante empregada, sendo o ácido tânico um polifenol com propriedade biológica bastante pronunciada. Objetivo: o objetivo deste estudo é avaliar o potencial biomodificador do ácido tânico (AT) em diferentes concentrações em colágeno dentinário. Métodos: os fatores sob investigação foram módulo de elasticidade, mensurado por meio de um ensaio de flexão de três pontos (n=10) e variação de massa (n=10), aferidos com uma balança de precisão, sendo, para tanto, avaliados os seguintes elementos: ácido tânico (0,1; 1 e 10%), proantocianidina (6,5%) e água destilada (controle). Resultados: quanto ao módulo de elasticidade, os grupos tratados com ácido tânico apresentaram valores, estatisticamente, superiores (p<0,05) aos demais grupos, não sendo observadas diferenças entre suas diferentes concentrações. Para os valores de variação de massa, os grupos que foram imersos em agentes biomodificadores apresentaram valores estatisticamente (p<0,05) superiores ao grupo controle. Conclusão: o ácido tânico se apresenta como um potencial agente biomodificador do colágeno dentinário, independente da concentração utilizada, aumentando o seu módulo de elasticidade e gerando um ganho de massa após uma hora de imersão.

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“…Four dentin bio-modifiers extracted from different plants were compared such as hydrolysable tannins from Aroeira, condensed tannins from grape seed with cardol and cardanol from cashew nut shell liquid. The results demonstrated that the four groups achieved cross-linking in dentin matrix after 1 min of treatment and the best bio-modifiers were cardol and cardanol [78].…”

Section: Dentin Modifier Dentin Pretreatment Collagen Cross-linkingmentioning

confidence: 96%

Polyphenols in Dental Applications

2020

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(1) Background: polyphenols are a broad class of molecules extracted from plants and have a large repertoire of biological activities. Biomimetic inspiration from the effects of tea or red wine on the surface of cups or glass lead to the emergence of versatile surface chemistry with polyphenols. Owing to their hydrogen bonding abilities, coordination chemistry with metallic cations and redox properties, polyphenols are able to interact, covalently or not, with a large repertoire of chemical moieties, and can hence be used to modify the surface chemistry of almost all classes of materials. (2) Methods: the use of polyphenols to modify the surface properties of dental materials, mostly enamel and dentin, to afford them with better adhesion to resins and improved biological properties, such as antimicrobial activity, started more than 20 years ago, but no general overview has been written to our knowledge. (3) Results: the present review is aimed to show that molecules from all the major classes of polyphenolics allow for low coast improvements of dental materials and engineering of dental tissues.

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Efficacy of new natural biomodification agents from Anacardiaceae extracts on dentin collagen cross-linking

Abstract: In conclusion, major components of CNSL yield overall best dentin biomodification outcomes when applied for one minute without staining the dentin collagen.

Cited by 44 publications

References 34 publications

Chlorhexidine and proanthocyanidin enhance the long-term bond strength of resin-based endodontic sealer

Chlorhexidine and proanthocyanidin enhance the long-term bond strength of resin-based endodontic sealer

Ácido tânico como agente biomodificador de dentina

Polyphenols in Dental Applications

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