Arthrofibrosis of the knee is one of the most common complications following ligamentous injury, affecting substantial amounts of patients following trauma and surgical procedures. Known symptoms of arthrofibrosis include limited range of motion, severe pain, joint stiffness, and joint effusion.1 Patients who develop arthrofibrosis often have a longer recovery time and an impaired healing process compared to non arthrofibrosis patients post ligamentous injury, due to long-lasting effects and stressors such as pain and instability. Such stressors can cause mechanical and psychological impairments that commonly prevent patients from doing normal day-to-day activities. In severe cases, arthrofibrosis can lead to unemployment due to the inability of patients to perform basic activities.1 Additionally, very few non-invasive treatment methods exist. A customary method of treatment for arthrofibrosis is arthroscopy to remove the deep tissue. Having to undergo a second surgery not only causes patients to be out of work for longer than planned, but also leads to higher hospital fees and bills. Reviewing the current state of literature, I identified diverse risk factors associated with arthrofibrosis, including age, sex, prior knee surgery, mass index, mechanism of injury, anatomical variations, autoimmune diseases, hormonal disorders, and more. Although these risk factors showed up in a wide range of the literature, there is a poor understanding of how these diverse risk factors affect the mechanism of deep tissue scarring. Additionally, many successful methods are being developed for treating arthrofibrosis in its late stages, such as surgical intervention and physio-therapeutic techniques. Still, no methods exist to evaluate the individualized prospective risk of patients. My paper is a narrative review of the literature, treatment strategies, and future directions, in which I included the epidemiology of arthrofibrosis, how multifaceted risk factors contribute to scarring, and a proposed protocol for a personalized risk score. While discussing scar-prevention strategy methods for arthrofibrosis, individualizing patient care must be considered in the treatment. The conclusions highlight the need for a multimodal approach, including a novel point-of-care system for high-risk individuals and a scar prevention strategy.