Efficacy of olanexidine gluconate in canine superficial pyoderma: a randomised, single‐blinded controlled trial

Abstract

Background Topical treatments can be beneficial for managing canine superficial pyoderma. A novel antiseptic agent, olanexidine gluconate, has become available recently for use in humans, and its efficacy for canine pyoderma as topical therapy is unknown. Objective The antimicrobial effect of olanexidine was evaluated using minimal inhibitory concentration (MIC) towards Staphylococcus pseudintermedius. Furthermore, its clinical efficacy in canine superficial pyoderma was assessed in a randomized, single‐blinded study. Animals Twenty‐eight client‐owned dogs with atopic dermatitis and superficial pyoderma. Methods and materials The MIC of olanexidine was determined for S. pseudintermedius isolates (n=73) by serial dilution of 96‐well broth microdilution method. Regarding the clinical trial, all recruited dogs were randomized into two groups; one treated with 1.5% olanexidine spray once daily and the other with a 3% chlorhexidine shampoo once a week for 2 times, respectively. Clinical assessment was performed at days 0 and 14 according to the guidelines of the Japanese Society of Antimicrobials for Animals. Results The MIC values for methicillin‐resistant S. pseudintermedius (MRSP) and methicillin‐sensitive S. pseudintermedius (MSSP) were 0.23 μg/ml and 0.24 μg/ml (P =0.9), respectively. In clinical trial, olanexidine and chlorhexidine showed substantial improvement in clinical presentation compared to the baseline. Conclusions and clinical importance Olanexidine showed comparable efficacy to chlorhexidine (P=0.73). Moreover, the MIC against S. pseudintermedius indicated high bactericidal activity, which was supported by the topical effectiveness of olanexidine.

Topical therapy for canine pyoderma: what is new?

“…16 In the past decade, several reviews 2,5,17 have already been published on the effectiveness of chlorhexidine shampoo for the treatment of superficial pyoderma. Since then, 12 papers have been published on the in vitro (n = 7) [18][19][20][21][22][23][24][25] and in vivo (4) [26][27][28][29] efficacy of chlorhexidine against bacterial pyoderma in dogs. In addition, 2 publications have assessed the efficacy of chlorhexidine baths and scrubs to reduce the bacterial skin contamination for the prevention of surgical site infections in dogs undergoing elective surgeries.…”

“…23 In regards to in vivo studies over the past 10 years, a total of 4 studies have assessed the clinical efficacy of chlorhexidine for the treatment of superficial pyoderma in dogs. The formulations used in these studies include a 4% shampoo and solution, 26 a 2% scrub, 27 a 3% shampoo, 28 and 3% pads. 29 The first study 26 was a randomized, blinded, antibiotic-controlled study assessing the efficacy of a twice-weekly 4% chlorhexidine shampoo along with a daily 4% chlorhexidine lotion in dogs (n = 25) with superficial pyoderma over a 4-week period.…”