Efficacy of Oral and Systemic Antibiotic Prophylaxis in Colorectal Operations

Preoperative antiseptics in clean/contaminated maxillofacial and oral surgery: prospective randomized study

“…There is no generally accepted protocol regarding the type of antibiotic or its dosage to be used for preoperative prophylaxis in surgical procedures in the oral cavity. Topical use of antibiotics, although relatively effective 5,6,9,15,16 , is not routine for preoperative prophylaxis probably because of the possibility of allergic reactions, the potential for inducing bacterial resistance and the cost. These negative effects can be avoided by using antiseptic solutions for preoperative prophylaxis with similar or even better efficacy in preventing local postoperative infections after intra-oral surgery 26 .…”

Clinical practice guidelines for antimicrobial prophylaxis in surgery

“…Regimens include oral neomycin and erythromycin plus i.v. administration of a cephalosporin, 416,417,429,445,449,478,479 metronidazole, 480,481 and gentamicin plus clindamycin. 466 Postoperative SSI rates in these studies ranged from 0% to 7%.…”

Combined Preoperative Mechanical Bowel Preparation With Oral Antibiotics Significantly Reduces Surgical Site Infection, Anastomotic Leak, and Ileus After Colorectal Surgery

“…[2][3][4][5] Despite this evidence, there is no longer general consensus among colorectal surgeons as to the appropriate use of MBP or its individual components. This is in part due to research showing that MBP alone does not confer protection against postoperative sepsis [6][7][8][9] and may be harmful.…”