Efficacy of Oral Itraconazole in the Treatment of Seborrheic Dermatitis in Vietnamese Adults Patients

Abstract

AIM:This longitudinal study aims to evaluate the efficacy of oral itraconazole in the treatment of seborrheic dermatitis in Vietnamese patients.METHODS:Thirty patients were enrolled at National Hospital of Dermatology and Venereology, Hanoi, Vietnam and were treated with oral itraconazole (200 mg daily in 14 days followed by 200 mg weekly in 4 weeks). The clinical severity was assessed by a four-parameter scoring system. All patients completed the six-week regimen with good adherence.RESULTS:At the week 2nd, 70% of the patients had moderate to severe diseases. At the week 6th, 63.4% of the patients achieve clearance of the lesions, and none had severe disease. No side effects were reported.CONCLUSION:Oral itraconazole can be an option for seborrheic dermatitis because of good efficacy, safety profile and adherence.

Kết Quả Điều Trị Viêm Da Tiết Bã Ở Người Lớn Bằng Itraconazol Phối Hợp E-Psora Tại Bệnh Viện Da Liễu Cần Thơ Năm 2021 – 2022

“…Sự tăng tiết bã nhờn là con đường chính giúp đưa thuốc đến lớp sừng của da. Tính ưa mỡ cao của itraconazol giúp thuốc tồn tại trong da và các phần phụ của da ở nồng độ điều trị trong một vài tuần ngay cả sau khi ngừng điều trị (hiệu ứng hồ chứa) [5]. Hiệu ứng này làm kéo dài hiệu quả điều trị của itraconazol và kéo dài thời gian tái phát bệnh.…”

Current controversies in trichology: a European expert consensus statement

“…Balance between bacteria and yeast might lead to a healthy skin The microorganisms living in our skin have been shown to protect against invading pathogens, and its role in some skin disorders has been recently studied by many researchers. In seborrhoeic dermatitis, some studies show that decreasing specific microorganisms of our skin might be beneficial for the course of the disease, 58 while other papers have found healthy bacteria that might protect against disease development. 59 In alopecia areata, the role of the skin microbiome is still unclear 60,61 and, even though some bacterial biomarkers are associated with the disease, further studies are necessary to prove their involvement in the pathophysiology of the disease and to test its potential as a diagnostic tool.…”

“…62,63 This recommendation did not reach consensus on the first round of the Delphi-like questionnaire. However, after exposing the evidence on the role of the microbiome in seborrhoeic dermatitis 58,59 and considering the similarities between seborrhoeic dermatitis and mild psoriasis, experts agreed on this recommendation.…”