Efficacy of Oxidized Regenerated Cellulose, SurgiGuard®, in Porcine Surgery

Abstract

PurposeAdequate hemostasis is important for postoperative outcomes of abdominal surgery. This study evaluated the hemostatic effects and accompanying histopathological changes of a novel oxidized regenerated cellulose, SurgiGuard®, during abdominal surgery.Materials and MethodsTen pigs underwent wedge resection of the spleen (1×1 cm) and liver (1.5×1.5 cm). The resected surface was covered with Surgicel® fabric or fibril type (Group A) or SurgiGuard® fabric or fibril type (Group B). Surgicel® and SurgiGuard® were randomized for attachment to the resected surface by fabric type (n=5) or fibril type (n=5). Blood loss was measured 5, 7, and 9 min after resection. Pigs were necropsied 6 weeks postoperatively to evaluate gross and histopathological changes.ResultsThere was no significant difference in total blood loss between groups [spleen fabric: Group A vs. Group B, 4.38 g (2.74–6.43) vs. 3.41 g (2.46–4.65), p=0.436; spleen fibril: Group A vs. Group B, 3.44 g (2.82–6.07) vs. 3.60 g (2.03–6.09), p=0.971; liver fabric: Group A vs. Group B, 4.51 g (2.67–10.61) vs. 6.93 g (3.09–9.95), p=0.796; liver fibril: Group A vs. Group B, 3.32 g (2.50–8.78) vs. 3.70 g (2.32–5.84), p=0.971]. Histopathological analysis revealed no significant difference in toxicities related to Surgicel® or SurgiGuard® [inflammation, fibrosis, foreign bodies, and hemorrhage (spleen: p=0.333, 0.127, 0.751, and 1.000; liver: p=0.155, 0.751, 1.000, and 1.000, respectively)].ConclusionSurgiGuard® is as effective and non-toxic as Surgicel® in achieving hemostasis after porcine abdominal surgery.

Hydrogen Peroxide Generation of Copper/Ascorbate Formulations on Cotton: Effect on Antibacterial and Fibroblast Activity for Wound Healing Application

“…It has recently been determined that greige cotton generates low levels of H 2 O 2 (5–50 micromolar). However, the mechanism of action of hydrogen peroxide production in the cotton fiber may be considered multifactorial, i.e., trace metals [ 15 , 16 ], polyphenols [ 15 , 17 ], peroxidase [ 17 ], super oxidase dismutase [ 18 , 19 ], and pectin [ 17 , 20 ], which are found in both brown and white cotton varieties, have been correlated with activity [ 15 ]. This study examines hydrogen peroxide production from unbleached cotton based on formularies prepared by simple modifications adoptable for dressing development.…”

Biological compatibility of oxidized cellulose vs. porcine gelatin to control bleeding in liver lesions in rats

“…Kim et al . 27 found no abscesses or infectious changes, nor signs of severe inflammation at microscopy when using oxidized regenerated cellulose in abdominal surgery in pigs. Yoon et al found similar results when investigating the use of oxidized regenerated cellulose in an animal model 28 .…”

Oxidized regenerated cellulose gauze as a hemostat in infantile hypertrophic pyloric stenosis

“…[11,16] Other complications are coronary ischemia (due to periaortic compression) and nerve injury (compression when left in and around bony canals) due to its hygroscopic nature. [13][14][15][16][17] No patient in Group B suffered from any complications related to Surgicel®.…”