Efficacy of oxycodone to facilitate general anaesthesia, haemodynamic changes and analgesia intra- and post-general surgery

Abstract

Background: Haemodynamic changes and post-operative analgesia is vital to maintain during general anaesthesia to conduct mild to moderate surgery. Objective: To evaluate the effect of oxycodone on physiologic changes following extubation and pain management after surgery. Methods: As the sole opioid administered to induce and maintain general anesthesia, intravenous oxycodone was the sole opioid used in this prospective, observational, descriptive study. As well as recording the number of extubation times and adverse events, we observed all of these patients to see if oxycodone alone was sufficient to provide adequate intraoperative and postoperative analgesia. Results: A total oxycodone dose of 0.35 ± 0.06 mg/kg was used for induction and 32.4 ± 3.21 mg/kg for maintenance of general anaesthesia. The dose was found to effectively maintain haemodynamic stability during surgery and good postoperative analgesia. A large number of patients took Oxycodone, resulting in deep sedation (five of the patients had sedation scores ≥4) and respiratory depression, as well as long recovery times in the post-anaesthetic care unit. The extubation time (18.5 ± 2.6 min) increased with increasing oxycodone doses. Conclusion:For minor/moderate surgeries, oxycodone may be the only opioid used. Due to its deep sedation effect, care should be taken.