Background: Haemodynamic changes and post-operative analgesia is vital to maintain during general anaesthesia to conduct mild to moderate surgery. Objective: To evaluate the effect of oxycodone on physiologic changes following extubation and pain management after surgery. Methods: As the sole opioid administered to induce and maintain general anesthesia, intravenous oxycodone was the sole opioid used in this prospective, observational, descriptive study. As well as recording the number of extubation times and adverse events, we observed all of these patients to see if oxycodone alone was sufficient to provide adequate intraoperative and postoperative analgesia. Results: A total oxycodone dose of 0.35 ± 0.06 mg/kg was used for induction and 32.4 ± 3.21 mg/kg for maintenance of general anaesthesia. The dose was found to effectively maintain haemodynamic stability during surgery and good postoperative analgesia. A large number of patients took Oxycodone, resulting in deep sedation (five of the patients had sedation scores ≥4) and respiratory depression, as well as long recovery times in the post-anaesthetic care unit. The extubation time (18.5 ± 2.6 min) increased with increasing oxycodone doses. Conclusion:For minor/moderate surgeries, oxycodone may be the only opioid used. Due to its deep sedation effect, care should be taken.

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Background: It was reported that platelet rich plasma injection is effective in the management of pain in adhesive capsulitis. Platelet rich plasma injection has multiple uses in the field of medical sciences. Objectives: The present study was undertaken to observe the effectiveness of intra articular autologous platelet rich plasma injection in the management of adhesive capsulitis of shoulder joint. Methods: The present study involved 30 patients within the age group of 30 to 60 years of age were included. Both males (n=12) and females (n=18) were present in the study. DASH score and visual analogue scores were assessed in the patients with 8 weeks follow up. Data was collected pre injection, post injection after four weeks. Results: There was a significant decrease in the scores of DASH and Visual analogue scale scores followed by the intervention. Conclusion:The study results demonstrated that the platelet rich plasma injection was very effective in reducing the pain levels of the patients. The study suggests need of further detailed studies in this area to recommend the use of plasma injection rich with platelets for management of adhesive capsulitis.

Background: As anesthesia is used routine basis on every surgery, it is required to assess the side effects of the anesthesia. Recent research has focused on the cognitive dysfunctions followed by general anesthesia. Objectives: The present study was undertaken to observe the influence of general anesthesia on cognitive functions in patients of abdominal surgery. Methods: The present study involved 40 patients of gastro intestinal surgery, within the age group of 20 to 60 years of age. Both the genders (males =15), Females =25) were included in the study Spatial and verbal memory was assessed using standard methods. Results: Majority of the patients belongs to age group of 41-50 years. Same was observed in case of male population. But more females belong to age group of 30-40 years (52%). There was significant decline in the spatial and verbal memory scores followed by the administration of anesthesia. The twotailed P value is less than 0.0001 for verbal memory. By conventional criteria, this difference is considered to be extremely statistically significant. The mean of Group One minus Group Two equals 3.00. 95% confidence interval of this difference: From 2.30 to 3.70. The two-tailed P value is less than 0.0001 for spatial memory. By conventional criteria, this difference is considered to be extremely statistically significant. The mean of Group One minus Group Two equals 3.00. 95% confidence interval of this difference: From 2.55 to 3.45. Conclusion:There was significant decline in the cognition scores followed by administration of anesthesia. There is a need to study more in this area to understand the relationship between the two variables and also plan the proper management strategies.

Background: There are very little studies in the area of post-surgical complications of cholecystectomy. It was reported that the patients who had underwent the gall bladder removal surgery develops some dysfunction in the liver profile. Objectives: The present study was undertaken to study the bilirubin profile in the patients of cholecystectomy. Methods: The present study involved 30 patients of gastro intestinal surgery, within the age group of 20 to 60 years of age. Both the genders (males =15), Females =15) were included in the study. Thorough clinical evaluation was conducted to all the patients. Direct and total bilirubin levels were estimated using the standard methods in the literature. Results:The two-tailed P value is less than 0.0001 for total bilirubin. By conventional criteria, this difference is considered to be extremely statistically significant. The mean of Group One minus Group Two equals 0.171000. 95% confidence interval of this difference: From 0.146150 to 0.195850. The twotailed P value is less than 0.0001 for direct bilirubin. By conventional criteria, this difference is considered to be extremely statistically significant. The mean of Group One minus Group Two equals -0.129000. 95% confidence interval of this difference: From -0.144995 to -0.113005. Conclusion:There was decrease in the total bilirubin levels but there was increase in the direct bilirubin levels in the patients. This study results support the views of earlier research. The study also recommends detailed research in this area.