Efficacy of ozonated water over chlorhexidine mouth rinse in chronic gingivitis patients – A comparative clinical study

Reddy, T. Roja; Priya, P. Santhi; Lakshmi, B. V.; Bai, Y. Durga; Kanth, Ravi; Sagar, Vidya; koppolu, Pradeep; AlGhamdi, Abdul Rahman Saeed

doi:10.1016/j.sdentj.2022.09.004

Cited by 5 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the studies also present limitations that hinder definitive conclusions. A fundamental limitation is the lack of standardization in ozone delivery methods and concentrations across studies [9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Developing practical storage solutions for ozonated water would be crucial for broader clinical applications. Another limitation is the absence of data on the optimal ozone concentration for effective treatment [9,[10][11][12][13]. Determining this optimal concentration is essential for establishing evidence-based practice guidelines for ozone therapy in gingivitis management.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of Ozonated Water on Gingivitis: A Systematic Review

Bansode,

et al. 2024

Cureus

View full text Add to dashboard Cite

Ozone has been used as an antibacterial agent for various purposes in healthcare. The use of ozone in dental practice is also well-established. Its utilization as a mouth rinse needs to be explored for further application in clinical practice, especially for cases of gingivitis, a common complaint. This systematic review aims to analyze the literature on the effects of ozonated water in managing gingival inflammation and bleeding across diverse populations. A systematic search adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted in PubMed, MEDLINE, Embase, and Cochrane. Studies published between January 2012 and December 2023 employing ozonated water as a treatment for gingivitis or gingival bleeding were included. Five studies met the inclusion criteria, demonstrating the varied efficacy of ozonated water. While some studies showed promising results in reducing bleeding and gingival inflammation, others indicated limitations compared to chlorhexidine. Methodological heterogeneity and lack of standardization were notable. The evidence suggests potential benefits of ozonated water in managing gingival inflammation and bleeding, but methodological variations hinder conclusive findings. Long-term studies with larger sample sizes and standardized protocols are needed to establish the effectiveness of ozonated water as an adjunctive therapy for gingival health.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effectiveness of Ozonated Water on Gingivitis: A Systematic Review

Bansode,

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Nevertheless, all of the results proved that the laser engraving machine and the protocol used in this study are indeed consistent, repeatable, and work properly as an alternative for wound-healing investigation. The development of this method also unlocks a limitless potency for us to perform a deeper investigation regarding the wound-healing process in fish, such as evaluating the effects of some adjuvant treatments, such as ozonized gel, that has been used for a periodontal patient [112], ozonized water, that has been tested to treat gingivitis patients and has been proven to be effective to reduce a microbial colony count [113], and probiotics, to investigate their mutual or synergize effect and their possible interaction.…”

Section: Functional Validation Of Antioxidants On Promoting Skin Woun...mentioning

confidence: 99%

Optimization of Laser-Based Method to Conduct Skin Ablation in Zebrafish and Development of Deep Learning-Based Method for Skin Wound-Size Measurement

Siregar,

Liu,

Casuga

et al. 2024

Inventions

View full text Add to dashboard Cite

Skin plays an important role as a defense mechanism against environmental pathogens in organisms such as humans or animals. Once the skin integrity is disturbed by a wound, pathogens can penetrate easily into a deeper part of the body to induce disease. By this means, it is important for the skin to regenerate quickly upon injury to regain its protective barrier function. Traditionally, scientists use rodents or mammals as experimental animals to study skin wound healing. However, due to concerns about animal welfare and increasing costs of laboratory animals, such as rodents, scientists have considered alternative methods of implementing replace, reduce, and refine (3Rs) in experimentation. Moreover, several previous studies on skin wound healing in fish used relatively expensive medical-grade lasers with a low calculation efficiency of the wound area, which led to human judgment errors. Thus, this study aimed to develop a new alternative model for skin wound healing by utilizing zebrafish together with a new rapid and efficient method as an alternative in investigating skin wound healing. First, in order to fulfill the 3Rs concept, the pain in the tested zebrafish was evaluated by using a 3D locomotion assay. Afterward, the obtained behavior data were analyzed using the Kruskal–Wallis test, followed by Dunn’s multiple comparisons tests; later, 3 watts was chosen as the power for the laser, since the wound caused by the laser at this power did not significantly alter zebrafish swimming behaviors. Furthermore, we also optimized the experimental conditions of zebrafish skin wound healing using a laser engraving machine, which can create skin wounds with a high reproducibility in size and depth. The wound closure of the tested zebrafish was then analyzed by using a two-way ANOVA, and presented in 25%, 50%, and 75% of wound-closure percentages. After imparting wounds to the skin of the zebrafish, wound images were collected and used for deep-learning training by convolutional neural networks (CNNs), either the Mask-RCNN or U-Net, so that the computer could calculate the area of the skin wounds in an automatic manner. Using ImageJ manual counting as a gold standard, we found that the U-Net performance was better than the Mask RCNN for zebrafish skin wound judgment. For proof-of-concept validation, a U-Net trained model was applied to study and determine the effect of different temperatures and the administration of antioxidants on the skin wound-healing kinetics. Results showed a significant positive correlation between the speed of wound closure and the exposure to different temperatures and administration of antioxidants. Taken together, the laser-based skin ablation and deep learning-based wound-size measurement methods reported in this study provide a faster, reliable, and reduced suffering protocol to conduct skin wound healing in zebrafish for the first time.

show abstract

“…This indicates that medicaments with anti-inflammatory properties, such as nonalcoholic chlorhexidine or herbal extracts with anti-inflammatory effects, could be beneficial when used with WFs. Research by Talasani et al [ 44 ] compared ozonated water with chlorhexidine mouth rinse, demonstrating that ozonated water was less effective in reducing plaque in gingivitis patients. Tecco et al [ 45 ] explored the effects of an ozonated water irrigator on the plaque index, revealing a significant decrease in the BOP index over time.…”

Section: Reviewmentioning

confidence: 99%

“…Research by Talasani et al [44] compared ozonated water with chlorhexidine mouth rinse, demonstrating that ozonated water was less effective in reducing plaque in gingivitis patients. Tecco et al [45] explored the effects of an ozonated water irrigator on the plaque index, revealing a significant decrease in the BOP index over time.…”

Section: Wf With Water Alone Versus Wf With Medicamentsmentioning

confidence: 99%

A Comparative Review of Water Flossers in Periodontal Therapy

Altalhi,

Alqahtani,

Alareefi

et al. 2023

Cureus

View full text Add to dashboard Cite

This study investigated the efficacy of water flossers (WFs), devices used to irrigate the interdental and subgingival areas, compared to other interdental care methods, in the management of periodontal disease. A computerized PubMed search was conducted by the author, encompassing the years 1962 to 2023. The year 1962 was selected due to it being the introduction of the first WF. Keywords included "oral irrigator", "efficacy," and "water flossers." The review provided a broad comparative assessment of WFs, rather than an exhaustive detailed article review. We discussed the history and evolution of commercially available WFs and introduced a novel classification system. The research also evaluated the performance of WFs in comparison to traditional and novel interdental care methods, focusing on crucial clinical parameters such as plaque removal efficiency and reduction in gingival inflammation. The results of the study reveal that WFs appear to be superior in the management of periodontal disease and have demonstrated effectiveness in a variety of indices. However, it's worth noting that the author did not statistically analyze any of the data. We identified gaps in the literature and found opportunities for further clinical studies. These findings hold implications for optimal periodontal disease prevention and management, addressing the evolving landscape of oral care practices.

show abstract

Efficacy of ozonated water over chlorhexidine mouth rinse in chronic gingivitis patients – A comparative clinical study

Cited by 5 publications

References 11 publications

Effectiveness of Ozonated Water on Gingivitis: A Systematic Review

Effectiveness of Ozonated Water on Gingivitis: A Systematic Review

Optimization of Laser-Based Method to Conduct Skin Ablation in Zebrafish and Development of Deep Learning-Based Method for Skin Wound-Size Measurement

A Comparative Review of Water Flossers in Periodontal Therapy

Contact Info

Product

Resources

About