Efficacy of pantoprazole 20???mg daily compared with esomeprazole 20???mg daily in the maintenance of healed gastroesophageal reflux disease: a randomized, double-blind comparative trial ??? the EMANCIPATE study

Abstract

Treatment with pantoprazole 20 mg once daily or esomeprazole 20 mg once daily provides similarly effective and well-tolerated maintenance of previously healed gastroesophageal reflux disease irrespective of baseline H. pylori status.

Esomeprazole in acute and maintenance treatment of reflux oesophagitis: a multicentre prospective study

“…The major limitation of our study is the lack of a comparator arm and the openlabel aspect of the trial design. [27][28][29][30] There is limited and controversial evidence that the presence of H. pylori infection may protect against GERD. 31 A recent systematic review confirmed that the prevalence of H. pylori infection is lower in patients with GERD than in those without the disease.…”

Potential Options to Optimize Therapy of Gastroesophageal Reflux Disease with Proton Pump Inhibitors

“…In this respect, other two comparative studies – involving 5,241 patients in the first and 284 in the second – have shown that esomeprazole (40 mg/day) is either superior to lansoprazole (30 mg/day) in healing esophagitis at 8 weeks (+10%: grade C; +18%: grade D) [51] or that there is no difference between the two drugs [52]. With regard to maintenance therapy of GERD, 20 mg/day esomeprazole has been found either superior or equivalent to 20 mg/day pantoprazole [53, 54] and superior to 15 mg/day lansoprazole after 6 months of continuous treatment [55, 56]. No long-term studies are available comparing head-to-head esomeprazole and either rabeprazole or omeprazole.…”

Medical treatment of gastroesophageal reflux disease

“…In the study of Scholten et al (12), in which 20 mg/day doses of pantoprazole and esomeprazole were compared in terms of their efficiencies for maintenance treatment, no difference was found with regard to the mean score of heartburn frequency and the mean number of tablets taken over 6 months. Similarly, in a study comparing more than 1200 cases, no difference was detected between the groups in terms of combined endoscopic and symptomatic remission rates after 6 months of maintenance treatment with 20 mg/day esomeprazole and pantoprazole (85% vs. 84%) (13). In the large population-based study of Labenz et al (14), it was reported that the endoscopic remission rate was significantly higher in the esomeprazole group following 8 weeks of acute treatment in patients using esomeprazole and pantoprazole at 6-month maintenance doses (87.0% vs. 74.9%, p<0.0001).…”