Efficacy of photodynamic therapy using TiO2 nanoparticles doped with Zn and hypericin in the treatment of cutaneous Leishmaniasis caused by Leishmania amazonensis

Lopera, Alex; Velásquez, Angela María Arenas; Linares, Irwin Alexander Patiño; Almeida, Letícia de; Fontana, Carla Raquel; García, Claudia; Graminha, Márcia Aparecida Silva

doi:10.1016/j.pdpdt.2020.101676

Cited by 44 publications

(17 citation statements)

References 32 publications

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“…Cu-doped ZnO-NPs are also shown with surge ROS level, intra-parasitically, after exposure to visible light [ 198 ]. On the similar proof-of-concept, Zn-doped-Ti0 2 -hypericin photosensitive nano-DDS formulated by Sepúlveda et al [ 199 ] demonstrated that the mixture of red and blue light posing an intensity of 22 mW/cm 2 caused 43–58% reduction in lesion parasitic burden in L. amazonensis infected BALB/c mice CL model. Moreover, its effectiveness as an antileishmanial nano-DDS candidate was found to be comparable with Amp-B.…”

Section: Distinctive Nano-dds For Leishmaniasismentioning

confidence: 89%

“…Photodynamic nano-DDS can be a suitable alternative to conventional anti-leishmanials. However, more advanced in vitro and preclinical assessment is required to promote their utilization in Leishmaniasis [ 199 ]. Another innovative approach, Amp-B-Ag NPs, were designed and investigated for in vitro anti-leishmanial activity.…”

Section: Distinctive Nano-dds For Leishmaniasismentioning

confidence: 99%

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Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

2021

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As a neglected tropical disease, Leishmaniasis is significantly instigating morbidity and mortality across the globe. Its clinical spectrum varies from ulcerative cutaneous lesions to systemic immersion causing hyperthermic hepato-splenomegaly. Curbing leishmanial parasite is toughly attributable to the myriad obstacles in existing chemotherapy and immunization. Since the 1990s, extensive research has been conducted for ameliorating disease prognosis, by resolving certain obstacles of conventional therapeutics viz. poor efficacy, systemic toxicity, inadequate drug accumulation inside the macrophage, scarce antigenic presentation to body’s immune cells, protracted length and cost of the treatment. Mentioned hurdles can be restricted by designing nano-drug delivery system (nano-DDS) of extant anti-leishmanials, phyto-nano-DDS, surface modified—mannosylated and thiolated nano-DDS. Likewise, antigen delivery with co-transportation of suitable adjuvants would be achievable through nano-vaccines. In the past decade, researchers have engineered nano-DDS to improve the safety profile of existing drugs by restricting their release parameters. Polymerically-derived nano-DDS were found as a suitable option for oral delivery as well as SLNs due to pharmacokinetic re-modeling of drugs. Mannosylated nano-DDS have upgraded macrophage internalizing of nanosystem and the entrapped drug, provided with minimal toxicity. Cutaneous Leishmaniasis (CL) was tackling by the utilization of nano-DDS designed for topical delivery including niosomes, liposomes, and transfersomes. Transfersomes, however, appears to be superior for this purpose. The nanotechnology-based solution to prevent parasitic resistance is the use of Thiolated drug-loaded and multiple drugs loaded nano-DDS. These surfaces amended nano-DDS possess augmented IC50 values in comparison to conventional drugs and un-modified nano-DDS. Phyto-nano-DDS, another obscure horizon, have also been evaluated for their anti-leishmanial response, however, more intense assessment is a prerequisite. Impoverished Cytotoxic T-cells response followed by Leishmanial antigen proteins delivery have also been vanquished using nano-adjuvants. The eminence of nano-DDS for curtailment of anti-leishmanial chemotherapy and immunization associated challenges are extensively summed up in this review. This expedited approach is ameliorating the Leishmaniasis management successfully. Alongside, total to partial eradication of this disease can be sought along with associated co-morbidities.

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Section: Distinctive Nano-dds For Leishmaniasismentioning

confidence: 89%

Section: Distinctive Nano-dds For Leishmaniasismentioning

confidence: 99%

Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

2021

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“…A study of Graminha group has designed an inorganic photosensitizer complex which uses TiO 2 NPs doped with Zn and hypericin (TiO 2 /Zn-HY) to treat cutaneous leishmaniasis caused by parasite Leishmania amazonensis (L. amazonensis ). TiO 2 /Zn-HY showed good anti leishmanial activity and low cytotoxicity against murine macrophage in visible light in vitro [68] . Under 22 mW/cm 2 intensity and 52.8 J/cm 2 fluency delivered blue and red light, the parasite level of L. amazonensis in infected BALB/c mice have decreased to 43%−58% of original level ( Fig.…”

Section: Pdt For Non-cancer Diseases and Conditionsmentioning

confidence: 95%

“… Tribenzoporphyrazines This photosensitizer displayed high killing efficiency against S. aureus (and potentially other Gram-positive bacteria), and it showed improved bacteria cell wall permeability Diseases caused by drug-resistant bacteria such ad S. aureus 660 nm light irradiation [67] TiO 2 /Zn-HY Inorganic photosensitizer complex which uses TiO 2 NPs doped with Zn and hypericin. Cutaneous Leishmaniasis caused by parasite L. amazonensis Visible light [68] NE-CUR A NE-CUR has devised which enhances performance of curcumin in PDT against vulvar intraepithelial neoplasia induced by HPV. Intraepithelial neoplasia of vulva caused by HPV infection Operating at 447±10 nm [ 69 , 70 ] 5-ALA An effective 5-ALA based PDT system to treat MRSA infected wounds of diabetic mice, PDT kills bacteria with a mechanism that is different from antibiotics Infection caused by drug-resistant bacteria such as MRSA-infected diabetic wounds 635 nm irradiation [71] Methylene blue A clinical report describes a case of palatal ulcer that is not sensitive to antibiotics but responds well to PDT and PBMT Palatal ulcer 660 nm-light irradiation [72] 5-ALA with MN A clinical trial involving 41 AA patients, most of the patients treated with this PDT approach showed reduced severity of their symptoms Immune-mediated disorder such as AA 630 nm irradiation [73] …”

Section: Introductionmentioning

confidence: 99%

Advances in photosensitizer-related design for photodynamic therapy

Zhou

Zhang

et al. 2021

Asian Journal of Pharmaceutical Sciences

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Photodynamic therapy (PDT) is highly effective in treating tumors located near body surface, offering strong tumor suppression and low damage to normal tissue nearby. PDT is also effective for treating a number of other conditions. PDT not only provide a precise and selective method for the treatment of various diseases by itself, it can also be used in combination with other traditional therapies. Because PDT uses light as the unique targeting mechanism, it has simpler and more direct targeting capability than traditional therapies. The core material of a PDT system is the photosensitizer which converts light energy to therapeutic factors/substances. Different photosensitizers have their distinct characteristics, leading to different advantages and disadvantages. These could be enhanced or compensated by using proper PDT system. Therefore, the selected type of photosensitizer would heavily influence the overall design of a PDT system. In this article, we evaluated major types of inorganic and organic PDT photosensitizers, and discussed future research directions in the field.

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“…1,2 In view of the universal spread of leishmaniasis, and its drug resistance, novel therapeutic nano-medicine approaches are of particular signicance. 3,4 So far, various nanoparticles such as ZnO, 5 TiO 2 , 6 and Au 7 have been studied for their leishmanicidal properties.…”

Section: Introductionmentioning

confidence: 99%

Calcium carbonate nanowires: greener biosynthesis and their leishmanicidal activity

et al. 2020

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Efficacy of photodynamic therapy using TiO2 nanoparticles doped with Zn and hypericin in the treatment of cutaneous Leishmaniasis caused by Leishmania amazonensis

Cited by 44 publications

References 32 publications

Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

Advances in photosensitizer-related design for photodynamic therapy

Calcium carbonate nanowires: greener biosynthesis and their leishmanicidal activity

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