Efficacy of Platelet-Rich Plasma Versus Autologous Fat Transfer With Nanofat in the Treatment of Infraorbital Dark Circles: A Single-Blinded Randomized Comparative Clinical Trial

Abstract

Patients who had never received any earlier treatment for periorbital hyperpigmentation. c Subjects willing to comply with the requirements of the study, including sequential photography, follow-up visits, and giving written informed consent. (2) Exclusion criteria: c Critical thrombocytopenia (,50,000/ml). c Hemodynamic instability. c Chronic medical illness (e.g., diabetes, chronic infections, and blood dyscrasias). c Local inflammation or infection at the site of the procedure. c Use of anticoagulants or nonsteroidal anti-inflammatory drugs (NSAID) within 48 hours of procedure, corticosteroid injection at treatment site within one month, or systemic use of corticosteroids within 2 weeks. c Recent fever, illness, or cancer. c Hemoglobin level , 10 g/dL.A simple randomization method was used to divide participants into 2 equal groups: Group A treated with PRP and Group B treated with autologous fat injection.

Fractional CO2 Laser Combined With Autologous Nanofat Injection Versus Fractional CO2 Laser Combined With Platelet-Rich Plasma in the Treatment of Atrophic Acne Scars: A Split-Face Comparative Study With Optical Skin Imaging

“…The preferred areas for fat harvesting were the lower abdomen and inner thighs because they are rich in stem cells. 13 First, anesthesia using Klein 14 tumescent solution (500 mL of 0.9% saline, 25 mL of 2% lidocaine, and 0.5 mL of 1:1,000 epinephrine) was infiltrated. Coleman 15 method was used, and fat was obtained through sustained negative pressure using a Sorensen harvester cannula (Tulip Medical Inc., San Diego, CA) attached to a 10-mL Luer-Lock syringe.…”

Advancements in Regenerative Medicine for Aesthetic Dermatology: A Comprehensive Review and Future Trends

“…In total, 73.7% of patients treated with combined fat transfer and nanofat and 33% of the PRP group showed an excellent and a moderate response in terms of improvement and patients' satisfaction. Non-responders were significantly higher in the PRP group (53.3% vs. 6.5%) [82]. Nilforoushzadehet al conducted a study on nine adult patients with atrophic acne scars on the face to investigate the effectiveness of a combined treatment with autologous fat transplantation, SVF cells, and PRP as the cell therapy techniques on atrophic acne scars.…”