Efficacy of Probiotics in Children and Adolescents With Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Study

Andrade, Paula Danielle Santa Maria Albuquerque de; Silva, Jorgete Maria e; Carregaro, Vanessa; Sacramento, Laís Amorim; Roberti, L; Aragon, Davi Casale; Carmona, Fábio; Roxo-Junior, Persio

doi:10.3389/fnut.2021.833666

Cited by 15 publications

(13 citation statements)

References 38 publications

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“…While enteral probiotics have been studied in detail [14][15][16][17][18][19] and they may include possibilities for primary prevention, the role of topical probiotics in the treatment of active AD remains uncertain. There have only been a few studies which have investigated the use of topical probiotics in AD and further evidence is needed to determine their efficacy, optimal dosing, and specific bacterial strains needed for treatment.…”

Section: Discussionmentioning

confidence: 99%

Treatment of atopic dermatitis with probiotic L. lactis lysate - A double-blinded, placebo-controlled pilot study

Salo

Remitz

Lauerma

et al. 2023

Preprint

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Background: Microbiome-targeted treatments have been investigated in atopic dermatitis (AD). We aimed to investigate the use of probiotic Lactococcus lactis lysate cream in AD. Methods: 13 patients with mild-to-moderate AD were treated with differently concentrated probiotic creams (3%, 10% and 30%) or placebo cream for 4 weeks. Disease severity (EASI, IGA), epidermal barrier function (TEWL) and patient-reported impact (DLQI, POEM, ADCT, pruritus and sleep disturbance VAS) were measured at baseline, 4 and 8 weeks. Comprehensive clinical data and laboratory values (blood eosinophil count, total serum IgE-levels and specific IgEs to aeroallergens) were obtained. Results: Comparison of the treatment groups showed no clear differences regarding AD severity (EASI, p=0.76, CI: 0.65-1.00), epidermal barrier dysfunction (TEWL, p=0.37, CI: 0.19-0.73) or patient-reported impact (DLQI, p=0.76, CI: 0.65-1.00; POEM, p=0.76, CI: 0.35-0.88; ADCT, p=0.72, CI: 0.65-1.00; pruritus VAS 0.67, CI: 0.55-1.00; sleep disturbance VAS, p=1.00, CI: 0.79-1.00) between different probiotic lysate concentrations and placebo. The probiotic lysate cream was well tolerated and there were no significant adverse effects. Limitations were a small and heterogenous patient groups and a relatively short follow-up with no evaluation of long-term effects. Conclusions: Topical probiotic L. lactis lysate cream showed no clear differences between the tratment groups in mild-to-moderate AD. Although topical probiotics have been reported effective in a limited number of studies, more placebo-controlled clinical studies are needed to explore their potential role in the treatment of AD.

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Section: Discussionmentioning

confidence: 99%

Treatment of atopic dermatitis with probiotic L. lactis lysate - A double-blinded, placebo-controlled pilot study

Salo

Remitz

Lauerma

et al. 2023

Preprint

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“…Os estudos foram realizados em distintas faixas etárias, que compreende de 0 a 19 anos de idade, sendo que o uso de probióticos foi avaliado de forma direta, através do tratamento de pacientes com dermatite atópica, em diferentes estágiosleve, moderado ou grave (IBÁÑEZ et al, 2018;AHN et al, 2020;JEONG et al, 2020;CUKROSWSKA et al, 2021;ANDRADE et al, 2022;CARUCCI et al, 2022), de forma preventiva por suplementação precoce em recém-nascidos (CABANA et al, 2017;) e, indiretamente, a partir de suplementação de gestantes, antes do parto e, após o parto, a partir da amamentação (WICKENS et al, 2018).…”

Section: Discussionunclassified

“…Após a análise de diversos trabalhos (KALLIOMÄKI et al, 2001;VILJANEN et al, 2004;FÖLSTER-HOLST et al, 2006;GRÜBER et al, 2007), Cukroswska e colaboradores ( 2021 Tratando-se do gênero Lactobacillus sp., a espécie L. rhamnosus foi estudada em sete trabalhos, tanto de forma isolada (CABANA et al, 2017;JEONG et al, 2020;CARUCCI al., 2022), quanto de forma simbiótica com mais de uma bactéria (IBÁÑEZ et al, 2018;CUKROWSKA et al, 2021;ANDRADE et al, 2022;WICKENS et al, 2022)…”

Section: Discussionunclassified

“…O uso de probióticos tem sido uma opção terapêutica frente à DA, uma vez que possuem funções imunorreguladoras (interagindo com diversas células participantes do sistema imunecélulas apresentadoras de antígenos e células T, por exemplo), contribuindo para a manutenção da homeostase imunológica, equilibrando as respostas imunes pró-inflamatórias e antiinflamatórias (MADSEN, 2006;KANG;IM, 2015;JEONG et al, 2020;ANDRADE et al, 2022;CARUCCI et al, 2022). Neste contexto, este trabalho tem como objetivo analisar o uso terapêutico e profilático de probióticos em pacientes pediátricos com dermatite atópica a partir de estudos já realizados.…”

Section: Introductionunclassified

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Uso Terapêutico E Preventivo De Probióticos Como Coadjuvantes Na Dermatite Atópica Na Pediatria

Lima¹,

Rocha²,

Silva³

et al. 2022

RGC

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Introdução: A Dermatite atópica (DA) consiste em uma patologia caracterizada por quadros inflamatórios associados à respostas do sistema imunológico. Em virtude de possíveis interações complexas entre fatores genéticos e ambientais, pode apresentar-se em diferentes graus de cronicidade, sendo necessárias intervenções terapêuticas e preventivas para minimizar os efeitos sintomatológicos. A utilização de probióticos tem demonstrado resultados positivos frente à DA, conforme revisado nos estudos. Objetivo: Identificar o uso terapêutico e preventivo de probióticos em pacientes pediátricos com dermatite atópica. Metodologia: Consistiu em uma revisão bibliográfica narrativa, analisando trabalhos presentes nos banco de dados, como SCIELO, LILACS e PubMed, atendendo aos descritores propostos para seleção dos artigos e critérios de elegibilidade. Resultados: Foram selecionados 8 artigos que atenderam aos critérios de elegibilidade em um escopo de 76 trabalhos identificados, os quais foram elencados em um quadro abrangendo informações como autores, ano de publicação, metodologia utilizada, microrganismos analisados, resultados obtidos e conclusões. Discussão: Os artigos demonstram a existência de efeitos positivos dos probióticos no que diz respeito à prevenção da DA, desde àqueles que foram suplementados indiretamente no período perinatal, até os que foram suplementados pós-parto. Conclusão: Foi possível identificar resultados significativos no tratamento e prevenção de dermatite atópica em pacientes pediátricos com o uso de probióticos, demonstrando a viabilidade da utilização dos mesmos, seja no período perinatal, seja após o parto.

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“…Depending on the source of bacteria, multiple factors could contribute to shaping the milk microbiota ( Andreas et al, 2015 ; Zimmermann and Curtis, 2020 ). On the one hand, the microbial composition and diversity of breast milk may be influenced by maternal characteristics, including ethnicity ( Deschasaux et al, 2018 ; Xu et al, 2020 ; Shafiee et al, 2022 ), pregnancy age, body mass index (BMI) ( Cabrera-Rubio et al, 2012 ), mode of delivery ( Cabrera-Rubio et al, 2012 ), parity, and intake of intrapartum antibiotics or probiotics ( de Andrade et al, 2021 ). Meanwhile, several studies have reported differences in the microbiota composition of HM in different geographic locations, just as they do in the human skin metagenome ( Gupta et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Contrasting Diversity and Composition of Human Colostrum Microbiota in a Maternal Cohort With Different Ethnic Origins but Shared Physical Geography (Island Scale)

Xie

Zhang

et al. 2022

Front. Microbiol.

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Colostrum represents an important source for the transfer of important commensal bacteria from mother to newborn and has a strong impact on the newborn’s health after birth. However, the composition of the colostrum microbiome is highly heterogeneous due to geographic factors and ethnicity (maternal, cultural, and subsistence factors). By analyzing the colostrum 16S rRNA gene full-length sequencing dataset in 97 healthy mothers (60 from Han, 37 from Li) from the Hainan island of China, we showed that the ethnic differences of the colostrum microbiome in a maternal cohort with different ethnic origins shared physical geography. Results indicated that the richness of microbial community in colostrum of Han women was higher than that of Li women, but there was no significant difference in Shannon index and invsimpson index between the two groups. Visualization analysis based on the distance showed an obvious ethnicity-associated structural segregation of colostrum microbiota. The relative abundance of Firmicutes was higher in the microbiota of the Han group than in Li’s, while Proteobacteria was on the contrary. At the genus level, the most dominant members of the Han and Li ethnic groups were Acinetobacter and Cupriavidus, two common environmental bacteria, respectively, although skin-derived Staphylococcus and Streptococcus were still subdominant taxa. Cupriavidus lacunae was the most dominant species in the Li group, accounting for 26.10% of the total bacterial community, but only 3.43% for the Han group with the most dominant Staphylococcus petrasii (25.54%), indicating that human colostrum microbiome was more susceptible to local living environmental factors. Hence, the ethnic origin of individuals may be an important factor to consider in human milk microbiome research and its potential clinical significance during the perinatal period in ethnic-diverse societies, even within a small geographic scale.

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Efficacy of Probiotics in Children and Adolescents With Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Study

Cited by 15 publications

References 38 publications

Treatment of atopic dermatitis with probiotic L. lactis lysate - A double-blinded, placebo-controlled pilot study

Treatment of atopic dermatitis with probiotic L. lactis lysate - A double-blinded, placebo-controlled pilot study

Uso Terapêutico E Preventivo De Probióticos Como Coadjuvantes Na Dermatite Atópica Na Pediatria

Contrasting Diversity and Composition of Human Colostrum Microbiota in a Maternal Cohort With Different Ethnic Origins but Shared Physical Geography (Island Scale)

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