Efficacy of prophylactic platelet rich plasma (PRP) following open saphenous vein harvesting in cardiac surgery

Abstract

Background: Wound infection represents a frequent trouble following open saphenous vein harvesting in cardiac surgery. Platelets’ growth factors are crucial for the healing process. Prophylactic platelet rich plasma (PRP) application on leg wound might reduce the incidence of saphenous vein harvest site infections in patients undergoing coronary artery bypass graft surgery (CABG). Methods: Between January 2009 and December 2020, 987 consecutive patients underwent CABG using saphenous vein as conduit graft and were retrospectively divided into two groups. All patients had standard surgical leg wound closure and wound care, but treatment group received adjunctive topical application of PRP (no-PRP and PRP group, respectively). The primary outcome was wound infection. Results: Saphenous vein harvest site infection rate was similar between PRP (3.5%) and No-PRP (5.2%) group, p = 0.215. The ASEPSIS score was lower for the PRP group (PRP: 3.6 ± 9.1 vs. No-PRP: 5.3 ± 11.2; p = 0.014). Performing a subgroup analysis, the diabetic patients (PRP-DM) group had a lower rate of infection than control group (No-PRP DM) (2.6% vs. 7.7%, p = 0.026). PRP-DM patients had an inferior ASEPSIS score (PRP-DM: 2.7 ± 8.3 vs. No PRP-DM: 7.5 ± 13.2, p < 0.001). Conclusions: Topical application of autologous PRP on saphenoug vein harvest site might reduce the rate of surgical site infection, with particular benefit among diabetic patients.

Platelet‐rich plasma influence on the sternal wounds healing: A meta‐analysis

“…In the research that was utilised for the meta-analysis, 8961 CS persons were in the utilised researchers' starting point, 3663 of them were utilising PRP, and 5298 were control. [12][13][14][15][16][17][18][19][20][21][22] PRP had significantly lower SWI, deep SWI, and superficial SWI, compared to control in CS persons. However, when interacting with its values, caution must be taken since a low sample size of some of the nominated researchers was found for the comparisons in the meta-analysis (5 out of 11 <200 persons).…”

“…Eleven papers, published between 2005 and 2022, from a total of 1098 linked research that met the inclusion criteria were chosen for the research. [12][13][14][15][16][17][18][19][20][21][22] The consequences of these investigations are accessible in Table 2. 8961 CS persons were in the utilised researchers' starting point, 3663 of them were utilising PRP, and 5298 were control.…”

“…Eleven papers, published between 2005 and 2022, from a total of 1098 linked research that met the inclusion criteria were chosen for the research 12‐22 . The consequences of these investigations are accessible in Table 2.…”

“…In the research that was utilised for the meta‐analysis, 8961 CS persons were in the utilised researchers' starting point, 3663 of them were utilising PRP, and 5298 were control 12‐22 . PRP had significantly lower SWI, deep SWI, and superficial SWI, compared to control in CS persons.…”

The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence

“…The first generation of platelet concentrates is termed platelet-rich plasma (PRP) which includes the addition of an anticoagulant to the blood sample which prevents clotting during the centrifugation cycle [ 34 ]. PRP is the most widely studied platelet concentrate in regenerative medicine with many investigations demonstrating its benefit in cardiac surgery [ 35 ], osteoarthritis [ 36 ], osteoporosis [ 37 ], dermal rejuvenation [ 34 ], and dentistry [ 38 , 39 ]. It possesses antimicrobial [ 40 ], anti-inflammatory [ 41 ], and regenerative properties [ 42 ].…”