Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Affective Disorders

Schläepfer, Thomas E.; Kosel, Markus; Nemeroff, Charles B.

doi:10.1038/sj.npp.1300038

Cited by 56 publications

(23 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The neurobiological effects of this novel therapeutic tool in humans are not sufficiently explained so far, but it has repeatedly been reported that the mesolimbic dopaminergic system plays an important role in mediating the mood improvements in depressed patients (review: Padberg and Möller, 2003;Schlaepfer et al, 2003). Recently, we found an increase in DA release in NAS, striatum, and hippocampus in response to acute rTMS , which could be replicated by others (Kanno et al, 2004;Zangen and Hyodo, 2002).…”

Section: Introductionsupporting

confidence: 64%

“…Although in most cases not anatomically precise (Herwig et al, 2001), rTMS effects in clinical studies most probably relate to frontal forebrain stimulation (review: eg Padberg and Möller, 2003;Schlaepfer et al, 2003). Consequently, to reliably investigate the underlying neurobiological effects in animal models, the adoption of equivalent stimulation conditions is indispensable.…”

Section: Rtms In Rat Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

Erhardt

Sillaber

Welt

et al. 2004

Neuropsychopharmacol

View full text Add to dashboard Cite

Recent studies in rodents have shown that withdrawal from chronic drug abuse is associated with a significant decrease in dopamine (DA) release in mesolimbic structures, especially in the shell region of the nucleus accumbens. Since the DA system is known to play an important role in reward processes, a withdrawal-associated impairment in mesolimbic DA-mediated transmission could possibly implicate reward deficit and thus enhance vulnerability to drug craving and relapse. We have previously demonstrated that acute repetitive transcranial magnetic stimulation (rTMS) has a modulatory effect on DA release in several areas of the rat brain, including dorsal striatum, hippocampus, and nucleus accumbens shell. In the present study, we investigated the possible use of rTMS as a tool in reestablishing the dysregulated DA secretion observed during withdrawal in morphine-sensitized male Sprague-Dawley rats. Using intracerebral microdialysis, we monitored the effects of acute rTMS (20 Hz) on the intra-accumbal release-patterns of DA in freely moving animals that were subjected to a morphine sensitization scheme for a period of 8 days. We provide first evidence that acute rTMS (20 Hz) is able to increase DA concentration in the shell region of the nucleus accumbens in both control animals and morphinesensitized rats during abstinence. The DA release in morphine-sensitized rats was significantly higher than in controls. rTMS, therefore, might gain a potential therapeutic role in the treatment of dysphoric and anhedonic states during drug withdrawal in humans.

show abstract

Section: Introductionsupporting

confidence: 64%

Section: Rtms In Rat Studiesmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

Erhardt

Sillaber

Welt

et al. 2004

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…A more comprehensive conceptualization of depression that inspires specific, targeted neuromodulatory intervention might allow better treatment modalities for depression associated with fewer side effects. Indeed, there were no side effects in any of our DBS patients.Other brain stimulation techniques exist that use electrical currents or magnetic fields, such as electroconvulsive therapy, repetitive transcranial magnetic stimulation, and vagus nerve stimulation, all of which have antidepressant effects (George et al, 2000;Schlaepfer and Kosel, 2004;Schlaepfer et al, 2003). However, like antidepressants, these methods are also less focused, affect larger areas of the brain not necessarily associated with depression, and induce side effects to various degrees.…”

mentioning

confidence: 99%

Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression

Schläepfer

Cohen

Frick

et al. 2007

Neuropsychopharmacol

Self Cite

919

561

View full text Add to dashboard Cite

Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression.Because a prominent clinical feature of depression is anhedoniaFthe inability to experience pleasure from previously pleasurable activitiesFand because there is clear evidence of dysfunctions of the reward system in depression, DBS to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. Three patients suffering from extremely resistant forms of depression, who did not respond to pharmacotherapy, psychotherapy, and electroconvulsive therapy, were implanted with bilateral DBS electrodes in the nucleus accumbens. Stimulation parameters were modified in a double-blind manner, and clinical ratings were assessed at each modification. Additionally, brain metabolism was assessed 1 week before and 1 week after stimulation onset. Clinical ratings improved in all three patients when the stimulator was on, and worsened in all three patients when the stimulator was turned off. Effects were observable immediately, and no side effects occurred in any of the patients. Using FDG-PET, significant changes in brain metabolism as a function of the stimulation in fronto-striatal networks were observed. No unwanted effects of DBS other than those directly related to the surgical procedure (eg pain at sites of implantation) were observed. Dysfunctions of the reward systemFin which the nucleus accumbens is a key structureFare implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. Neuropsychopharmacology (2008) 33, 368-377; doi:10.1038/sj.npp.1301408; published online 11 April 2007 Keywords: deep brain stimulation; major depression; anhedonia; nucleus accumbens; brain stimulation; Cg25 INTRODUCTIONTraditional methods of alleviating depression largely stem from serendipitous observations of antidepressant effects of substances such as iproniazid (originally developed as a treatment for tuberculosis) or imipramine (originally developed as a treatment for schizophrenia). In particular, increasing levels of monoamine neurotransmitters in the synaptic cleft are associated with improvements of depressive symptoms. This insight led to a more targeted drug discovery process, resulting in drugs with fewer side effects, such as SSRIs. These medication treatments, in conjunction with certain methods of psychotherapy and electroconvulsive therapy, are effective at alleviating depressive symptomatology in most patients (Andrews and Nemeroff, 1994;Mann, 2005). However, these treatments do not work for all patients. A sizable minority of patients does not respond. Indeed, twelve percent of patients suffering from major depression have a poor outcome even after 5 years of treatment (Keller et al, 1992). Patien...

show abstract

“…В качестве альтернативы высокочастотной рТМС не-которыми исследователями [150] предлагалось использо-вать низкочастотную стимуляцию правой DLPFC. Одна-ко результаты проведенных двойных слепых плацебо-контролируемых исследований оказались противоречи-выми.…”

Section: депрессияunclassified

Repetitive transcranial magnetic stimulation in neurology and psychiatry

Chervyakov

Poydasheva

Korzhova

et al. 2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

View full text Add to dashboard Cite

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Affective Disorders

Cited by 56 publications

References 51 publications

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression

Repetitive transcranial magnetic stimulation in neurology and psychiatry

Contact Info

Product

Resources

About