Efficacy of MAS063DP lotion vs 0.02% triamcinolone acetonide lotion in improving post‐ablative fractional CO₂ laser resurfacing wound healing: a split‐face, triple‐blinded, randomized, controlled trial

Abstract

Proven as effective acne scar treatment, ablative fractional carbon dioxide (AFCO ) laser requires post-laser wound healing care. MAS063DP is a multicomponent nonsteroidal anti-inflammatory moisturizer for effective post-laser treatment. This study compares the efficacy of MAS063DP and 0.02% triamcinolone acetonide (TA) lotion for post-laser wound healing and complications. A split-face, triple-blinded, clinical study was performed in 16 patients, aged 20-50 years, receiving AFCO on both sides of the face, with MAS063DP on one side and 0.02% TA on the other side for 7 days twice daily. Digital photography, hemoglobin, and melanin index at baseline were obtained immediately after laser treatment and then at days 3, 5, 7, and 30. Erythema, edema, crusting, adverse effects, and post-inflammatory hyperpigmentation (PIH) were followed every visit. Sixteen patients, mean age 38.6 (8.4) years, with moderate-severe atrophic scar and skin phototype III-IV completed the study. Clinical improvement of edema, erythema, crusting, and hyperpigmentation was observed from day 3 to day 30 (P < 0.001), with no statistically significant difference in both groups. There was also no statistical difference of hemoglobin, melanin index, and texture at days 3, 5, 7, and 30. Melanin index at day 30 was significantly less than baseline in both MAS063DP and 0.02% TA. With PIH in 50% of cases, both treatments demonstrated good safety profiles and no serious adverse reactions. MAS063DP could be an effective treatment for post-laser wound healing and complications, compatible to 0.02% TA.

Sun protection behavior and knowledge of patients attending laser clinic to prevent adverse events of laser: A cross‐sectional, single‐center, tertiary care study

“…To date, dermatologists recognize how to prevent adverse effects postlaser treatment in medical practice and routinely provide this information to their patients. Strategic recommendations to prevent PIH include sun protection and broad‐spectrum sunscreen utilization before and after laser, use of cooling devices during treatment to diminish heat of the laser, and application of moisturizer with anti‐inflammatory ingredients or topical anti‐inflammatory medication (eg, topical corticosteroid) postoperatively …”

Efficacy of anti‐inflammatory moisturizer vs hydrophilic cream in elderly patients with moderate to severe xerosis: A split site, triple‐blinded, randomized, controlled trial

“…While, other ingredients comprise aqua, ethylhexyl palmitate, pentylene glycol, arachidyl alcohol, behenyl alcohol, arachidyl glucoside, glyceryl stearate, PEG‐100 stearate, butylene glycol, capryloyl glycine, bisabolol, carbomer, ethylhexylglycerin, piroctone olamine, sodium hydroxide, allantoin, DMDM hydantoin, disodium EDTA, and propyl gallate and ceteth 20. Also, the product (oil in water emulsion) contains emollient, humectants, and occlusive components …”

“…Thai elderly patients aged 50‐70 years and diagnosed with moderate to severe xerosis categorized by xerosis severity scale (XSS for 3‐6) and Fitzpatrick skin type III (54.1%) and IV (45.9%) were enrolled. Exclusion criteria were those sensitive to the test agents, current skin diseases requiring for treatment, conditions interfering to the study, use of oral/topical steroids or oral isotretinoin, diuretics or immunosuppressant or laser, and photo or light therapy during 4 weeks prior to the study.…”

Effects of Cold Atmospheric Pressure Plasma on Accelerating Acute Wound Healing: A Comparative Study among 4 Different Treatment Groups

“…In Japan, topical application of ointments including steroids or petrolatum [9], bFGF preparation sprays, or gels containing fullerene [10] are generally applied as post-radiation treatment, as well as protection from solar radiation. In other countries, occlusive dressing material, beta-sitosterol ointment [9], MAS063DP, and 0.02% triamcinolone acetonide lotion [23] have been used in addition to the treatments applied in Japan. However, a standard treatment has yet to be established, and the choice of treatment protocols depends on each institution and the treating surgeon.…”