Efficacy of silver diamine fluoride as an antibacterial as well as antiplaque agent compared to fluoride varnish and acidulated phosphate fluoride gel: An in vivo study

Shah, Shalin; Bhaskar, Vijay; Venkataraghavan, Karthik; Choudhary, Prashant; Mahadevan, Ganesh; Trivedi, Krishna

doi:10.4103/0970-9290.123374

Cited by 39 publications

(17 citation statements)

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“…Although no reported study has compared the antibacterial effect of these agents with that of SDF on a mature biofilm caries model, the findings are consistent to those of previous differently designed studies (14,18,25). Shah et al reported that SDF application reduced the saliva S. mutans count to a greater degree than APF gel or 6% NaF fluoride varnish (15). They found that APF and fluoride varnish had a similar effect on microorganisms.…”

Section: Discussionmentioning

confidence: 88%

“…Several different fluoride agents, such as acidulated phosphate fluoride (APF), sodium fluoride, stannous fluoride, and amine fluoride have been used clinically (9)(10)(11)(12)(13). However, the antibacterial activity of these materials is limited, and attempts to develop more effective antibacterial materials are ongoing (11,14,15). One of these materials, silver diamine fluoride (SDF), is a safe, cost-effective, efficient, and noninvasive cariespreventive agent that has been used for treatment of both primary and permanent teeth (16,17).…”

Section: Introductionmentioning

confidence: 99%

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Effects of different antibacterial agents on enamel in a biofilm caries model

et al. 2015

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Using a mature biofilm model, the aim of this study was to evaluate the effectiveness of different antibacterial agents in comparison with silver diamine fluoride (SDF). Forty-eight saliva-coated enamel slabs were inoculated with Streptococcus mutans monospecies biofilm. The biofilms were then exposed to 10% sucrose in tryptone yeast-extract culture medium, 8 times per day for 7 days. After the biofilm growth period, the enamel slabs were treated with one of the following substances: 1) distilled water; 2) SDF; 3) acidulated phosphate fluoride (APF); 4) ammonium hexafluorosilicate (AHF); 5) ammonium hexafluorosilicate + cetylpyridinium chloride (AHF+CPC); or 6) 0.2% chlorhexidine (CHX). After these treatment procedures, the samples were incubated at 37ºC for 2 days, and the numbers of viable microorganisms in the biofilms were counted. The number of viable bacteria was significantly reduced by all of the antibacterial agents (P < 0.05). However, SDF showed the highest antibacterial activity (P < 0.05), and the effectiveness of the other agents was lower (P < 0.05). SDF has a highly effective antibacterial action against cariogenic Streptococcus mutans biofilm; none of the other fluoride agents used in this study, or 0.2 CHX agent, showed an antibacterial effect comparable to that of SDF. (J Oral Sci 57, [367][368][369][370][371][372] 2015)

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Effects of different antibacterial agents on enamel in a biofilm caries model

et al. 2015

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“…Dental caries is a prevalent bacterial, multifactorial, dynamic disease caused by an imbalance between demineralization and remineralization processes of tooth structure. It is considered one of the most common diseases affecting humans [ 1 ]. Different cost effective preventive measures are needed as a mean to reduce the effects of dental caries such as pain, and loss of natural teeth [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Glutathione Bio-Molecule on Tooth Discoloration Associated with Silver Diammine Fluoride

Sayed

Matsui

Hiraishi

et al. 2018

IJMS

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This study evaluated the effect of Glutathione (GSH) bio-molecule on the reduction of enamel and dentin discoloration after application of 38% silver diammine fluoride solution (SDF). One hundred and twenty bovine teeth specimens were used. The enamel and dentin specimens were divided into three groups: (1) SDF only (control); (2) SDF followed by application of a potassium iodide solution (KI); and (3) SDF mixed with 20% GSH. Half the specimens were exposed to light and the remainder kept in dark conditions (n = 10) Color changes were measured using a spectrophotometer at the following time intervals: before solution application (baseline) and immediately after application, then 3, 6, 24, 48, 72 h, and 7, 10 and 14 days. SEM/EDS analysis was performed on treated enamel and dentin. Statistical analysis was done using a repeated measures ANOVA test. The spectrophotometer results showed that the SDF group exhibited the greatest color changes under both light exposed and dark conditions, while SDF + GSH group was effective in decreasing the color changes in both light and dark conditions. The SDF + KI group showed an insignificant color changes over time. SEM/EDS analysis showed different patterns for the silver crystal formation in each group (SDF, SDF + GSH, and SDF + KI group). It was concluded GSH can effectively minimize color changes after application of SDF, especially on enamel and to a lesser extent on dentin.

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“…Currently, silver diamine fluoride (SDF) salts are seeing a resurgence in use for caries prevention and inhibition of oral biofilm formation . However, the topical application of SDF caused a staining of organic material as found in pellicle and active caries, due to the reaction of free silver ions with organic material .…”

Section: Introductionmentioning

confidence: 99%

Effect of silver diamine fluoride and potassium iodide on residual bacteria in dentinal tubules

2015

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Background: This study evaluated the antimicrobial effect of a silver diamine fluoride (SDF)/potassium iodide (KI) product (Riva Star) on the viability of intratubular bacteria. Methods: Forty-five dentine discs prepared from caries-free maxillary premolars were randomly divided into nine groups. Group 1 (negative control) contained non-infected sound dentine discs. The remaining discs were infected with Streptococcus mutans suspension and received dentine treatments as follows: Group 2 (positive control), discs were left untreated; Group 3 SDF/KI (Riva Star); Group 4 chlorhexidine (CHX); Group 5 CHX + SDF/KI; Group 6 Carisolv; Group 7 Carisolv + SDF/KI; Group 8 Papacarie, and Group 9 Papacarie + SDF/KI. The discs were then fractured into two halves, stained with fluorescent LIVE/DEAD stain and observed using confocal laser scanning microscopy. Results: SDF/KI exhibited a potent antibacterial effect, as represented by a significantly higher percentage of dead bacteria, in comparison with Carisolv and Papacarie (p < 0.05). The application of SDF/KI following Carisolv and Papacarie chemomechanical caries removel gels significantly reduced the viability of intra-tubular bacteria in these groups. Conclusions: The use of the silver diamine fluoride/potassium iodide product is effective in reducing the numbers of S. mutans in dentinal tubules infected with this organism.

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Efficacy of silver diamine fluoride as an antibacterial as well as antiplaque agent compared to fluoride varnish and acidulated phosphate fluoride gel: An in vivo study

Abstract: In vivo application of SDF on enamel significantly decreases S. mutans counts as compared to fluoride varnish and APF gel.

Cited by 39 publications

References 0 publications

Effects of different antibacterial agents on enamel in a biofilm caries model

Effects of different antibacterial agents on enamel in a biofilm caries model

Effect of Glutathione Bio-Molecule on Tooth Discoloration Associated with Silver Diammine Fluoride

Effect of silver diamine fluoride and potassium iodide on residual bacteria in dentinal tubules

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