Efficacy of silver nanoparticles against the adults and eggs of monogenean parasites of fish

Pimentel-Acosta, Citlalic Altagracia; Morales-Serna, Francisco Neptalí; Chávez-Sánchez, Marı́a Cristı́na; Lara, Humberto H; Pestryakov, Alexey; Bogdanchikova, Nina; Fájer-Ávila, Emma Josefina

doi:10.1007/s00436-019-06315-9

Cited by 27 publications

(26 citation statements)

References 48 publications

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“…Nanotechnology is an emerging technology with applications in industrial aquaculture, having the potential to enhance production and ultimately contribute to global food security (Luis, Campos, Oliveira, & Fraceto, 2019; Shah & Mraz, 2019; Valentim et al, 2018a, 2018b). Nanobiotechnology is among the recent advancements of nanotechnology and is used specifically in the treatment of diseases in aquaculture (Luis et al, 2019; Pimentel‐Acosta et al, 2019; Shah & Mraz, 2019). Hence, nanotechnology can reduce economic losses caused by mass mortality in commercial aquaculture.…”

Section: Introductionmentioning

confidence: 99%

“…Monogenea is a diverse class of ectoparasitic worms with a direct life cycle, of which many species are highly pathogenic and resistant to treatment in fish farming (Morales‐Serna et al, 2019; Pimentel‐Acosta et al, 2019; Valentim et al, 2018a, 2018b). Monogeneans mainly affect the gills of fish and in high abundance cause epithelial and haematological alterations (Costa et al, 2017; Restiannasab, Hemmatzadeh, Khara, & Saljoghi, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Nanoemulsions with oleoresin of Copaifera reticulata (Leguminosae) improve anthelmintic efficacy in the control of monogenean parasites when compared to oleoresin without nanoformulation

Malheiros

Sarquis

Ferreira

et al. 2020

Journal of Fish Diseases

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This study compared the in vitro anthelmintic activity of Copaifera reticulata oleoresin (200, 400, 600, 800 and 1,000 mg/L) and of nanoemulsions prepared with this oleoresin (50, 100, 150, 200 and 250 mg/L) against monogeneans on the gills of Colossoma macropomum. The major compounds present in the oleoresin of C. reticulata were γ‐macrocarpene (14.2%), α‐bergamotene (13.6%), β‐selinene (13.4%) and β‐caryophyllene (11.7%). All concentrations of the nanoemulsion and the oleoresin without nanoformulation showed anthelmintic efficacy against monogeneans, and higher concentrations led to more rapid parasite mortality. Structural damages to the tegument of the parasites exposed to C. reticulata oleoresin were observed with scanning electron microscopy. At two hours of exposure, fish showed 100% tolerance to all nanoemulsion concentrations used in the in vitro assays, whereas 100% mortality was shown in the fish exposed to the oleoresin without nanoformulation after one hour. The results of this study suggest that nanoemulsions with oleoresin of C. reticulata have advantages in the control and treatment of monogenean infections in C. macropomum when compared to the oleoresin without nanoformulation. In addition, since nanoemulsions with the C. reticulata oleoresin are safe to control monogeneans, the efficacy of these nanoformulations may be assayed in therapeutic baths to treat C. macropomum infected by monogeneans.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanoemulsions with oleoresin of Copaifera reticulata (Leguminosae) improve anthelmintic efficacy in the control of monogenean parasites when compared to oleoresin without nanoformulation

Malheiros

Sarquis

Ferreira

et al. 2020

Journal of Fish Diseases

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“…Silver nanoparticles (AgNPs) are broad spectrum biocides inhibiting viruses [ 17 , 18 ], bacteria [ 19 , 20 ], and parasites [ 21 , 22 ]. Our group previously reported on the potent activity of positively charged AgNPs against single-species biofilms formed by C. albicans , mostly via cell wall disruption [ 23 ], and those formed singly by MRSA, by thinning and permeabilization of the bacterial cell wall, destabilization of the peptidoglycan layer, and subsequent leakage of intracellular content, causing bacterial cell lysis [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Mixed Biofilms of Candida albicans and Methicillin-Resistant Staphylococcus aureus by Positively Charged Silver Nanoparticles and Functionalized Silicone Elastomers

Lara

Lopez-Ribot

2020

Pathogens

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Both bacterial and fungal organisms display the ability to form biofilms; however, mixed bacterial/fungal biofilms are particularly difficult to control and eradicate. The opportunistic microbial pathogens Candida albicans and Staphylococcus aureus are among the most frequent causative agents of healthcare-acquired infections, and are often co-isolated forming mixed biofilms, especially from contaminated catheters. These mixed species biofilms display a high level of antibiotic resistance; thus, these infections are challenging to treat resulting in excess morbidity and mortality. In the absence of effective conventional antibiotic treatments, nanotechnology-based approaches represent a promising alternative for the treatment of highly recalcitrant polymicrobial biofilm infections. Our group has previously reported on the activity of pure positively charged silver nanoparticles synthesized by a novel microwave technique against single-species biofilms of C. albicans and S. aureus. Here, we have expanded our observations to demonstrate that that silver nanoparticles display dose-dependent activity against dual-species C. albicans/S. aureus biofilms. Moreover, the same nanoparticles were used to functionalize catheter materials, leading to the effective inhibition of the mixed fungal/bacterial biofilms. Overall, our results indicate the potent activity of silver nanoparticles against these cross-kingdom biofilms. More studies are warranted to examine the ability of functionalized catheters in the prevention of catheter-related bloodstream infections.

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“…Several studies have evaluated the effectiveness of AgNPs in aquatic diseases control because to their antimicrobial potential against bacteria, virus and parasites (Barakat, El-Sayed & Gohar, 2016;Morales-Covarrubias et al, 2016;Acedo-Valdez et al, 2017;Pimentel-Acosta et al, 2019). However, this is the first work that examine the efficacy of Argovit-4 (AgNPsbased formulation) as a potential antiviral additive in feed to protect the health of shrimp L. vannamei against WSSV.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the potential of AgNPs as antimicrobial agent, in aquaculture industry, concerns remain regarding the potential negative impact to the marine and freshwater environment. However, to date, there have not been clear the in vivo toxicity of silver nanoparticles in marine environment, as the effects depend on AgNP properties (particle size, surface area, shape), concentration, AgNP colloidal stability, aggregation grade, sedimentation, and on the amount and species of products yielded from chemical interactions between AgNPs and other variables (Fabrega et al, 2011;Sharma et al, 2019;Pimentel-Acosta et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a new Argovit as an antiviral agent included in feed to protect the shrimpLitopenaeus vannameiagainst White Spot Syndrome Virus infection

Romo-Quiñonez

Sánchez

Álvarez-Ruíz

et al. 2020

PeerJ

Self Cite

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In this study, four experimental assays were conducted to evaluate the use of a new silver nanoparticle formulation named Argovit-4, which was prepared with slight modifications to enhance its biological activity against white spot syndrome virus (WSSV) in shrimp culture. The goals of these assays were to (1) determine the protective effect of Argovit-4 against WSSV, (2) determine whether Argovit-4 supplemented in feed exhibits toxicity towards shrimp, (3) determine whether Argovit-4 as antiviral additive in feed can prevent or delay/reduce WSSV-induced shrimp mortality, and (4) determine whether Argovit-4 supplemented in feed alters the early stages of the shrimp immune response. In bioassay 1, several viral inocula calibrated at 7 SID50(shrimp infectious doses 50% endpoint) were exposed to 40, 100, 200 and 1,000 ng/SID50 of Ag+ and then intramuscularly injected into shrimp for 96 h. In bioassay 2, shrimp were fed Argovit-4 supplemented in feed at different concentrations (10, 100 and 1,000 µg per gram of feed) for 192 h. In bioassay 3, shrimp were treated with Argovit-4 supplemented in feed at different concentrations and then challenged against WSSV for 192 h. In bioassay 4, quantitative real-time RT-qPCR was performed to measure the transcriptional responses of five immune-relevant genes in haemocytes of experimental shrimp treated with Argovit-4 supplemented in feed at 0, 6, 12, 24 and 48 h. The intramuscularly injected Argovit-4 showed a dose-dependent effect (p < 0.05) on the cumulative shrimp mortality from 0–96 h post-infection. In the second bioassay, shrimp fed Argovit-4 supplemented in feed did not show signs of toxicity for the assayed doses over the 192-h experiment. The third and fourth bioassays showed that shrimp challenged with WSSV at 1,000 µg/g feed exhibited reduced mortality without altering the expression of some immune system-related genes according to the observed level of transcriptional. This study is the first show that the new Argovit-4 formulation has potential as an antiviral additive in feed against WSSV and demonstrates a practical therapeutic strategy to control WSSV and possibly other invertebrate pathogens in shrimp aquaculture.

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Efficacy of silver nanoparticles against the adults and eggs of monogenean parasites of fish

Cited by 27 publications

References 48 publications

Nanoemulsions with oleoresin of Copaifera reticulata (Leguminosae) improve anthelmintic efficacy in the control of monogenean parasites when compared to oleoresin without nanoformulation

Nanoemulsions with oleoresin of Copaifera reticulata (Leguminosae) improve anthelmintic efficacy in the control of monogenean parasites when compared to oleoresin without nanoformulation

Inhibition of Mixed Biofilms of Candida albicans and Methicillin-Resistant Staphylococcus aureus by Positively Charged Silver Nanoparticles and Functionalized Silicone Elastomers

Evaluation of a new Argovit as an antiviral agent included in feed to protect the shrimpLitopenaeus vannameiagainst White Spot Syndrome Virus infection

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